Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids

Authors

  • V. O. Chornous
  • A. O. Palamar
  • I. M. Yaremiy
  • N. D. Yakovychuk
  • M. V. Vovk

DOI:

https://doi.org/10.14739/2310-1210.2014.2.25447

Keywords:

[(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids, reduction, antioxidant, antimicrobial and antifungal activity

Abstract

By reduction of available [(1-aryl-5-formylimidazole-4-il)thio] acetic acids with sodium borohydrideinaqueous solution in presence of 20% solution of sodium hydroxide [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids were synthesized. Their structure was proved by results of measurements of IR-, NMR 1H and chromatography-mass pectra. Primary  screening of antioxidant properties showed that in in vitro experiments all of the studied compounds are active in range of concentrations between10-1-10-3mole/l, and the highest antioxidant effect is shown by {[5-hydroxymethyl-1-(3-methylphenyl)-1Н-imidazole-4-il]thio} acetic acid in concentration 10-3 М, which is credibly the same as the effect of thiotriazolin in the same concentration. It was found that the synthesized compounds show moderate antimicrobial and antifungal effect.

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1.
Chornous VO, Palamar AO, Yaremiy IM, Yakovychuk ND, Vovk MV. Synthesis and evaluation of antioxidant, antimicrobial and antifungal effect of [(5-hydroxymethyl-1H-imidazole-4-il)thio] acetic acids. Zaporozhye Medical Journal [Internet]. 2014Jun.19 [cited 2024Dec.24];16(2). Available from: http://zmj.zsmu.edu.ua/article/view/25447

Issue

No. 2 (2014): Zaporozhye medical journal

Section

Problems of pharmacy

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