Prognostic significance of GDF 15 and NTproBNP levels and echocardiographic parameters in patients with heart failure with preserved ejection fraction and asymptomatic diastolic dysfunction after myocardial infarction on the background of arterial hyperte
DOI:
https://doi.org/10.14739/2310-1210.2014.3.25596Keywords:
heart failure, growth differentiation factor 15, myocardial infarction, hypertensionAbstract
Aim. Chronic heart failure with preserved ejection fraction is related to syndromes with a poor prognosis. 93 patients with preserved left ventricular ejection fraction (EF>45%) after myocardial infarction on the background of arterial hypertension were examined. Prognostic significance of GDF 15 and NTproBNP levels (ELISA) and echocardiographic parameters were evaluated.
Methods and results. Patients were divided into 2 groups. The 1st included 62 patients with heart failure with preserved ejection fraction. The 2nd – 31 patients with asymptomatic diastolic dysfunction. The greatest prognostic potential in patients with heart failure with preserved ejection had GDF-15, NTproBNP levels and E/E' ratio. Only GDF-15 had prognostic significance in patients with asymptomatic diastolic dysfunction. Evaluation of GDF-15 and NTproBNP biomarkers levels in combination increased positive predictive value of each of them in both groups of study. Add of the E/E' ratio or atrial volume index evaluation to the GDF- 15 and NTproBNP biomarkers levels combination assessment lead to the further increase of the positive predictive value of biomarkers.
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