Peculiarities of molecular-biological and hormonal tumor status in patients with endometrial cancer

Authors

DOI:

https://doi.org/10.14739/2310-1210.2022.5.257005

Keywords:

endometrial cancer, biological tumor markers, expression, estrogens, progesterone, relapse

Abstract

Endometrial cancer (EC) ranks second in the structure of oncogynecological diseases both in Ukraine and worldwide. More than 80 % of recurrences occur in the first two years after surgical treatment. Molecular biological markers are extensively studied in different oncological diseases, because they allow to understand the etiology and pathogenesis of malignant growth more deeply.

Aim. To study molecular biological markers and tumor hormonal status in patients with EC and determine their practical significance.

Materials and methods. Molecular biologic markers of the tumor were studied in 89 stage I–IV EC patients. To study the hormonal status of the tumor in EC patients, 119 examinations were carried out.

Results. Significant correlations were found between the level of molecular biological marker (MBM) expression, hormonal status of the tumor, the presence of disease recurrence, and the age of EC patients. The novelty of the study lay in the substantiation of treatment individualization for EC patients based on the determination of the tumor molecular biological characteristics and their prognostic value. It has been proven that the expression level of the studied MBM, ER and PR receptors in EC patients differed depending on age, presence, localization and severity of disease recurrence. A group of patients with a high risk of the disease recurrence has been revealed among EC patients.

For the first time, a technology has been developed for the combined treatment of patients with I–II (T1-2N0M0) stages of EC with a negative receptor status (EP–, PR–) and a high risk of the disease recurrence to assess MBM levels (VEGF, Bcl-2, Ki-67), degree of differentiation, myometrial invasion depth and tumor localization in the uterine cavity allowing to individualize the choice of adjuvant therapy regimen, thus improving the effectiveness of treatment and preventing the occurrence of locoregional relapses and distant metastases.

Conclusions. For the first time, the expression levels of the studied molecular biological markers and ER and PR receptors have been shown to differ depending on age, localization, and relapse severity, which could be used to determine the risk of relapse in EC patients.

Author Biographies

O. A. Mikhanovskyi, SO “Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, PhD, DSc, Professor, Head of the Department of Oncological Gynecology, Leading Researcher of the Department of Oncological Surgery, Oncological Gynecology Group

Yu. V. Kharchenko, SO “Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, PhD, Senior Researcher, Department of Oncological Surgery, Oncological Gynecology Group

O. M. Sukhina, SO “Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, PhD, DSc, Professor, Radiation Therapist, Department of Radiation Therapy

I. M. Kruhova, SO “Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, PhD, Senior Researcher, Department of Oncological Surgery, Oncological Gynecology Group

N. M. Shchyt, SO “Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, Gynecologic Oncologists, Department of Oncological Gynecology

References

Fedorenko, Z. P., Hulak, L. O., Mykhailovych, Yu. I., Horokh, Ye. L., Ryzhov, A. Iu., Sumkina, O. V., & Kutsenko, L. B. (2019). Rak v Ukraini, 2017-2018. Zakhvoriuvanist, smertnist, pokaznyky diialnosti onkolohichnoi sluzhby [Cancer in Ukraine, 2017-2018. Morbidity, mortality, performance of the oncology service]. Biuleten Natsionalnoho kantser-reiestru Ukrainy, (20). [in Ukrainian]. http://www.ncru.inf.ua/publications/BULL_20/index.htm

Mikhanovskij, O. A., Sukhina, O. M., Kharchenko, Y. V., Shchyt, N. M., Fedorenko, N. V., Teplova, M. A., & Moiseyenko, Y. A. (2020). Morfolohichne obhruntuvannia radiomodyfikatsii peredoperatsiinoi promenevoi terapii u khvorykh na rozpovsiudzhenyi rak endometriia [Morphological substantiation of radiomodification of preoperative radiotherapy in patients with advanced endometrial cancer]. Ukrainskyi radiolohichnyi ta onkolohichnyi zhurnal, 28(2), 87-105. [in Ukrainian]. https://doi.org/10.46879/ukroj.2.2020.87-105

Aghajanian, C., Filiaci, V., Dizon, D. S., Carlson, J. W., Powell, M. A., Secord, A. A., Tewari, K. S., Bender, D. P., O'Malley, D. M., Stuckey, A., Gao, J., Dao, F., Soslow, R. A., Lankes, H. A., Moore, K., & Levine, D. A. (2018). A phase II study of frontline paclitaxel carboplatin bevacizumab, paclitaxel carboplatin temsirolimus, or ixabepilone carboplatin bevacizumab in advanced recurrent endometrial cancer. Gynecologic Oncology, 150(2), 274-281. https://doi.org/10.1016/j.ygyno.2018.05.018

Wakayama, A., Kudaka, W., Matsumoto, H., Aoyama, H., Ooyama, T., Taira, Y., Arakaki, Y., Shimoji, Y., Nakasone, T., Nishihira, K., Kaneshima, I., Tamaki, T., Yoshimi, N., & Aoki, Y. (2018). Lymphatic vessel involvement is predictive for lymph node metastasis and an important prognostic factor in endometrial cancer. International Journal of Clinical Oncology, 23(3), 532-538. https://doi.org/10.1007/s10147-017-1227-6

Anastasi, E., Gigli, S., Ballesio, L., Angeloni, A., & Manganaro L. (2018). The Complementary Role of Imaging and Tumor Biomarkers in Gynecological Cancers: An Update of the Literature. Asian Pacific Journal of Cancer Prevention, 19(2), 309-317. https://doi.org/10.22034/APJCP.2018.19.2.309

Mikhanovskii, A. A., Kharchenko, Y. V., Teplova, M. A., Krugova, I. N., Moiseyenko, Y. A., Shchyt, N. N., & Pionitkovska, O. V. (2019). Vyznachennia rivnia ekspresii molekuliarno-biolohichnykh markeriv v pukhlyni khvorykh na rak endometriiu I-IV stadii z metoiu prohnozuvannia retsydyvu zakhvoriuvannia [Determination of expression rate of molecular biological markers in tumor of patients with stage I-IV endometrial cancer to predict the disease relapse]. Mizhnarodnyi medychnyi zhurnal, 25(4), 54-58. [in Ukrainian]. https://doi.org/10.37436/2308-5274-2019-4-12

Mikhanovskyi, O. A., Teplova, M. A., Krugova, I. M., Kharchenko, Yu. V., Shchyt, N. M., Fedorenko N. V., & Moiseienko, Yu. A. (2016). Immunogistohimicheskie faktory prognoza raka endometriya [Immunohistochemical factors of endometrial cancer prognosis]. Mezhdunarodnyy meditsinskiy zhurnal, 24(2), 49-52. [in Russian]. http://www.imj.kh.ua/archive/2018/2/10

Chepets, A. V. (2016). Sravnitel'naya immunogistokhimicheskaya kharakteristika ekspressii prognosticheskikh markerov nemetastaticheskoi i metastaticheskoi invazivnoi adenokartsinomy tela matki [Comparison of immunohistochemical characteristics of prognostic markers expression in non-metastatic and metastatic invasive endometrioid endometrial carcinoma]. Zaporozhye Medical Journal, (5), 58-63. [in Russian]. https://doi.org/10.14739/2310-1210.2016.5.82627

Sato, N., Takagi, K., Suzuki, T., Miki, Y., Tanaka, S., Nagase, S., Warita, H., Fukudo, S., Sato, F., Sasano, H., & Ito, K. (2014). Immunolocalization of Corticotropin-releasing hormone (CRH) and its receptors (CRHR1 and CRHR2) in human endometrial carcinoma CRHR1 as a potent prognostic factor. International Journal of Gynecological Cancer, 24(9), 1549-1557. https://doi.org/10.1097/IGC.0000000000000269

Babak,V. P., Biletskyi, A. Ya., Prystavka, O. P., & Prystavka, P. O. (2001). Statystychna obrobka danykh [Statistical data processing]. Kyiv. [in Ukrainian].

Published

2022-10-22

How to Cite

1.
Mikhanovskyi OA, Kharchenko YV, Sukhina OM, Kruhova IM, Shchyt NM. Peculiarities of molecular-biological and hormonal tumor status in patients with endometrial cancer. Zaporozhye Medical Journal [Internet]. 2022Oct.22 [cited 2024Nov.25];24(5):574-9. Available from: http://zmj.zsmu.edu.ua/article/view/257005

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Section

Original research