The protein and lipid peroxidation and antioxidant system in patients with HIV/AIDS-associated newly diagnosed pulmonary tuberculosis depending on the severity of immunodeficiency, clinical and radiological changes

Authors

  • R. M. Yasinskiy
  • A. V. Fedorec
  • A. G. Makarovych
  • O. O. Kovalenko
  • D. V. Miroshnychenko

DOI:

https://doi.org/10.14739/2310-1210.2014.3.26031

Keywords:

HIV infections, Acquired Immunodeficiency Syndrome, pulmonary Tuberculosis

Abstract

Aim. The clinical, radiological and immunological aspects of co-infection are actively studied nowadays. To identify the peculiarities of oxidative status in patients with HIV/AIDS-associated pulmonary tuberculosis depending on the severity of immunosuppression, and clinical and radiological data 47 patients were examined.

Methods and results. Protein peroxidation products were determined with the method by B. Halliwell, lipid peroxidation – with method by V.B. Gavrilov, catalase activity - M.A. Koroljuk method, SOD activity – by B. Haglof. Patients with HIV/AIDS-associated newly diagnosed pulmonary tuberculosis had mostly marked increase in levels of 254 nm intermediate mass molecules at immunodeficiency.

Conclusion. Rise of protein peroxidation products levels and the decrease of catalase activity at extensive pulmonary or severe extrapulmonary lesions and in cases with multiple organs dysfunction were determined too.

References

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How to Cite

1.
Yasinskiy RM, Fedorec AV, Makarovych AG, Kovalenko OO, Miroshnychenko DV. The protein and lipid peroxidation and antioxidant system in patients with HIV/AIDS-associated newly diagnosed pulmonary tuberculosis depending on the severity of immunodeficiency, clinical and radiological changes. Zaporozhye medical journal [Internet]. 2014Jul.4 [cited 2024Apr.26];16(3). Available from: http://zmj.zsmu.edu.ua/article/view/26031

Issue

No. 3 (2014): Zaporozhye medical journal

Section

Original research

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