The protein and lipid peroxidation and antioxidant system in patients with HIV/AIDS-associated newly diagnosed pulmonary tuberculosis depending on the severity of immunodeficiency, clinical and radiological changes

Authors

  • R. M. Yasinskiy
  • A. V. Fedorec
  • A. G. Makarovych
  • O. O. Kovalenko
  • D. V. Miroshnychenko

DOI:

https://doi.org/10.14739/2310-1210.2014.3.26031

Keywords:

HIV infections, Acquired Immunodeficiency Syndrome, pulmonary Tuberculosis

Abstract

Aim. The clinical, radiological and immunological aspects of co-infection are actively studied nowadays. To identify the peculiarities of oxidative status in patients with HIV/AIDS-associated pulmonary tuberculosis depending on the severity of immunosuppression, and clinical and radiological data 47 patients were examined.

Methods and results. Protein peroxidation products were determined with the method by B. Halliwell, lipid peroxidation – with method by V.B. Gavrilov, catalase activity - M.A. Koroljuk method, SOD activity – by B. Haglof. Patients with HIV/AIDS-associated newly diagnosed pulmonary tuberculosis had mostly marked increase in levels of 254 nm intermediate mass molecules at immunodeficiency.

Conclusion. Rise of protein peroxidation products levels and the decrease of catalase activity at extensive pulmonary or severe extrapulmonary lesions and in cases with multiple organs dysfunction were determined too.

References

Volchegorskij,I.A., Novosyolov, P.N., &Bolotov, A.A.(2008) Pokazateli sistemy perekisnoe okislenie lipidov – antioksidantnaya zashhita kak prediktory neblagopriyatnogo techeniya infil'trativnog otuberkuleza legkikh [Indicators of lipidperoxidation–antioxidant protection system as predictors of an unfavorable course оf infiltrative pulmonary tuberculosis].Problemy tuberkuleza i boleznej legkikh, 4, 28–32. [in Russian].

Haertynova, I.M., Valiev, R.Sh., Cibul'kin, A. P.,et al.(2009) Kliniko-immunologicheskie osobennosti VICH-infekcii, sochetannoj s tuberkulyozom [Clinical and immunological features of HIV infection, associated with tuberculosis]. Problemy tuberkuleza i boleznej legkikh, 6,41–46. [in Russian].

Nagoyev, B. S.,&Sabanchiyeva,Zh. Kh. (2007) Sostoyanie sistemy perekisnogo okisleniya lipidov i antioksidantnoj sistemy u bol'nykh VICH-infekciej [Status of lipid peroxidation and antioxidant system in patients with HIV infection].Terapevticheskij arkhiv,12,70–72. [in Russian].

Sotnichenko, S.A. (2008) Nekotorye immunologicheskie aspekty u bol'nykhVICH-infekciej v razlichnykh stadiyakh, sochetannoj s tuberkulyozom [Some immunological aspects in HIV-infected patients at different stages, associated with tuberculosis]. Immunologiya, 1,4–6. [in Russian].

Schelkanova, A. I.,&Kravchenko, A. V. (2004) Osobennosti techeniya tuberkuleza, sochetannogo s VICH-infekciej [Characteristics of tuberculosis running with HIV-infection].Terapevticheskij arkhiv, 4,20–24. [in Russian].

Haglof, B. (2003) Cu, Zn-superoxidedismutase, Mn-superoxidedismutase, catalase and glutationperoxidase in limphocytes and erythrocytes in insulindependent diabetic children.ActaEndocr,102,235–239.

Halliwell, B., &Yutteridge, M.C. (1999) Free radical in Biology and Medicine.Oxpord, Clarendon press.

Oguntibeju, O.O., Esterhuyse, A.J., &Truter, E.J. (2010) Possible role of red palm oil supplementation in reducing oxidative stress in HIV/AIDS and TB patients. A review.Journal of medicinal plants research, 4(3),188–196.

Oguntibeju, O.O., Esterhuyse, A.J., &Truter, E.J. (2012) Red palm oil and its antioxidant potential in reducing oxidative stress in HIV/AIDS and TB patients.Biomedical Science, Engineering and technology,1,151–164.

Alves, C., Milla, J., Nicolas, J., Gatell, J., Garcia, F., Moreno, A., etal. (2001). Reappraisal of the aetiology and prognostic factors of severe acute respiratory failure in HIV patients.European Respiratory Journal, 17(1), 87–93.

Shah, R.P., Pawar, G.B., &Bhiwgade, D.A. (2009) Analysis of adenosine deaminase enzyme in HIV and tuberculosis in Indian population.International Journal of Biotechnology Applications,1,32–40.

How to Cite

1.
Yasinskiy RM, Fedorec AV, Makarovych AG, Kovalenko OO, Miroshnychenko DV. The protein and lipid peroxidation and antioxidant system in patients with HIV/AIDS-associated newly diagnosed pulmonary tuberculosis depending on the severity of immunodeficiency, clinical and radiological changes. Zaporozhye Medical Journal [Internet]. 2014Jul.4 [cited 2024Nov.24];16(3). Available from: http://zmj.zsmu.edu.ua/article/view/26031

Issue

Section

Original research