Association of CYP2E1*6 polymorphism of gene CYP2E1 with the risk and severity of chronic hepatitis C

Authors

  • V. V. Godovan
  • K. V. Ostapchuk

DOI:

https://doi.org/10.14739/2310-1210.2014.3.26034

Keywords:

Hepatitis C virus, Disease Susceptibility, Genetic Polymorphism

Abstract

Aim. The effectiveness of treatment of chronic hepatitis C (CHC) depends on the genetic characteristics of the patients. The aim was to analyze the association of CYP2E1*6 polymorphism with the risk of development and severity of CHC.

Methods and results. We determined the frequency of CYP2E1*6 polymorphism in 77 patients with CHC and 64 healthy donors using molecular genetic methods. Case histories were retrospectively analyzed. We did not find association between CYP2E1*6 polymorphism and the risk of CHC. The majority of patients with genotype CD had more frequently normal alanineaminotransferase levels than the patients with genotype DD (55,6 % vs 27,1 %, p = 0,026). Patients with genotype DD more often had different stages of liver fibrosis than the patients with genotype CD (34,5 % greater, p = 0,009, OR 4,24, 95% CI 1,37 – 12,93).

Conclusion.This indicates that the genotype DD of  the gene CYP2E1 was associated with more severe course of CHC.

References

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How to Cite

1.
Godovan VV, Ostapchuk KV. Association of CYP2E1*6 polymorphism of gene CYP2E1 with the risk and severity of chronic hepatitis C. Zaporozhye Medical Journal [Internet]. 2014Jul.4 [cited 2024Nov.13];16(3). Available from: http://zmj.zsmu.edu.ua/article/view/26034

Issue

No. 3 (2014): Zaporozhye medical journal

Section

Original research

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