A method for the biological age of the heart determination

Authors

DOI:

https://doi.org/10.14739/2310-1210.2022.6.261227

Keywords:

biological age of the heart, accelerated aging, echocardiography

Abstract

Determination of the human heart biological age (BA) is relevant for timely stratification of the risk of developing diseases, prevention, control of individual aging rate and geroprotective therapy.

Aim. To study age-related changes in echocardiographic examination of the heart and to develop a formula for estimating the BA of the human heart.

Materials and methods. Echocardiographic examinations of the heart were performed in 188 practically healthy people aged 30 to 79 years (73 men and 115 women), who signed an informed consent and had no clinically significant diseases in the anamnesis or at the moment. The examined were divided into age groups: I (n = 25) – 30–39 years, II (n = 40) – 40–49 years, III (n = 38) – 50–59 years, IV (n = 46) – 60–69 years, V (n = 39) – 70–79 years old. Echocardiography with Doppler in continuous-wave, pulse modes and colour mapping of flow and tissue was performed on a device Xario SSA-660A (Toshiba, Japan), sensor – PST-30BT 3.0 MHz. The state of systolic and diastolic function of the ventricles of the heart was assessed, myocardial stiffness indicators were calculated. To obtain BA formula, the calculation of the multiple linear regression equation was used based on significant features.

Results. Significant increase in atrial size with age, development of diastolic dysfunction, increase in left and right ventricular myocardial infarction were found. Based on the data of the study by the method of step-by-step multiple linear regression, a formula for estimating the biological age of the human heart was obtained. The multiple correlation coefficient was a fairly high value of R = 0.847, the adjusted coefficient of determination R2 = 0.701 (F = 43.496, P ˂ 0.00001). The mean absolute error of age calculation (M ± σ) was 5.55 ± 4.24 years. The proposed formula for determining the biological age of the heart can be used for early diagnosis of accelerated aging.

Conclusions. An increase in the size of the atria, the development of concentric hypertrophy of the left atrium and diastolic dysfunction, and an increase in the myocardial stiffness of the left and right ventricles of the heart, which occur with age in practically healthy people, were revealed. A formula for determining the BA of the heart with good model quality was developed using the multiple linear regression method taking into account age-related changes in the echocardiographic parameters.

Author Biographies

L. A. Bodretska, SI “D. F. Chebotarev Institute of Gerontology” of the NAMS of Ukraine”, Kyiv

MD, PhD, Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

I. S. Shapovalenko, SI “D. F. Chebotarev Institute of Gerontology” of the NAMS of Ukraine”, Kyiv

MD, PhD, Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

A. V. Pisaruk, SI “D. F. Chebotarev Institute of Gerontology” of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Head of the Laboratory for Mathematical Modeling of Aging Processes

I. A. Antoniuk-Shchehlova, SI “D. F. Chebotarev Institute of Gerontology” of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Leading Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

O. V. Bondarenko, SI “D. F. Chebotarev Institute of Gerontology” of the NAMS of Ukraine”, Kyiv

MD, PhD, Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

S. S. Naskalova, SI “D. F. Chebotarev Institute of Gerontology” of the NAMS of Ukraine”, Kyiv

MD, PhD, Senior Researcher of the Department of Clinical Physiology and Pathology of Internal Organs

V. B. Shatylo, SI “D. F. Chebotarev Institute of Gerontology” of the NAMS of Ukraine”, Kyiv

MD, PhD, DSc, Professor, Head of the Department of Clinical Physiology and Pathology of Internal Organs

References

Akhaladze, M. H. (2007). Otsinka tempu starinnia, stanu zdorovia i zhyttiezdatnosti liudyny na osnovi vyznachennia biolohichnoho viku [Assessment of Aging Rate, Health State, and Man’s Viability on the Basis of Biological Age Determination (Doctoral dissertation)]. Kyiv. [in Ukrainian].

Damen, J. A., Pajouheshnia, R., Heus, P., Moons, K., Reitsma, J. B., Scholten, R., Hooft, L., & Debray, T. (2019). Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease: a systematic review and meta-analysis. BMC medicine, 17(1), 109. https://doi.org/10.1186/s12916-019-1340-7

Hamczyk, M. R., Nevado, R. M., Barettino, A., Fuster, V., & Andrés, V. (2020). Biological Versus Chronological Aging: JACC Focus Seminar. Journal of the American College of Cardiology, 75(8), 919-930. https://doi.org/10.1016/j.jacc.2019.11.062

Monge García, M. I., & Santos, A. (2020). Understanding ventriculo-arterial coupling. Annals of translational medicine, 8(12), 795. https://doi.org/10.21037/atm.2020.04.10

Ikonomidis, I., & Vlastos, D. (2022). Corrigendum to 'The role of ventricular-arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association' [Eur J Heart Fail 2019;21:402-424]. European journal of heart failure, 24(8), 1452. https://doi.org/10.1002/ejhf.2452

Flack, J. M., & Adekola, B. (2020). Blood pressure and the new ACC/AHA hypertension guidelines. Trends in cardiovascular medicine, 30(3), 160-164. https://doi.org/10.1016/j.tcm.2019.05.003

Kanda, Y. (2013). Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone marrow transplantation, 48(3), 452-458. https://doi.org/10.1038/bmt.2012.244

Hurianov, V. H., Liakh, Yu. Ye., Parii, V. D., Korotkyi, O. V., & Chalyi, O. V. (2018). Posibnyk z biostatystyky. Analiz rezultativ medychnykh doslidzhen u paketi EZR (R-statistics) [A guide to biostatistics. Analysis of the results of medical records in the package EZR (R-statistics)]. Kyiv: Vistka. [in Ukrainian].

Downloads

Published

2022-12-20

How to Cite

1.
Bodretska LA, Shapovalenko IS, Pisaruk AV, Antoniuk-Shchehlova IA, Bondarenko OV, Naskalova SS, Shatylo VB. A method for the biological age of the heart determination. Zaporozhye Medical Journal [Internet]. 2022Dec.20 [cited 2024Dec.28];24(6):652-7. Available from: http://zmj.zsmu.edu.ua/article/view/261227

Issue

Vol. 24 No. 6 (2022)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)