DYNAMICS OF PARAMETERS OF PROINFLAMMATORY ACTIVATION IN PATIENTS WITH HYPERTENSION UNDER INFLUENCE OF CANDESARTAN THERAPY
DOI:
https://doi.org/10.14739/2310-1210.2014.5.28726Keywords:
Hypertension, Proinflammatory Activation, C-Reactive Protein, Soluble Form Of Intercellular Adhesion Molecule-1, Tumor Necrosis Factor-alfa, CandesartanAbstract
Aim. Proinflammatory activation is one of the possible pathogenetic mechanisms of formation and progression of hypertension. 107 patients with essential hypertension (EH) II stage was included into the study of the pro-inflammatory activation.
Methods and results. Levels of C-reactive protein (CP), α-tumor necrosis factor (α-TNF) and soluble form of intercellular adhesion molecule-1 (sICAM-1) in the serum were studied by ELISA before and after 12 weeks of treatment with candesartan. 31 healthy subjects were included in the control group. It is found that C-reactive protein in 5,18 times (p<0,05), α-tumor necrosis factor on the 39,04% (p<0,05) and sICAM-1 to 41, 87% (p<0,05) higher in hypertensive patients with stage II than those of the control group. Significant reductions of CRP in the blood serum by 70,33%, α-TNF – by 19,94% and sICAM-1 inserum by 18,46% compared to baseline (p<0,05) were found under the influence of candesartan therapy.
Conclusion. These data indicate the presence of activation of proinflammatory processes in hypertensive patients with significant progression according to the degree of blood pressure and additional anti-inflammatory properties of candesartan.References
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