Dependence of the index of left ventricular hypertrophy in hypertensive patients on Arg389Gly polymorphism of β1-adrenoceptor gene and T393C of α-subunit of G-protein gene
DOI:
https://doi.org/10.14739/2310-1210.2014.5.28727Keywords:
Left Ventricular Hypertrophy, Genetic Polymorphism, Beta Adrenergic Receptors, G-proteinAbstract
Aim. Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular complications. Every year the number of publications written concerning the genetic determinism of its progression is increasing. To determine the dependence of LVH on Arg389Gly polymorphisms of β1-adrenoceptor gene (ADRβ1) and T393C of α-subunit of G-protein gene (GNAS1) the echocardiography and polymerase chain reaction were performed in 166 patients with hypertension.
Methods and results. It was found that in men, who had T393T genotype, higher levels of left ventricular myocardium mass and index of left ventricular myocardium mass were observed comparing to patients with T393C and C393C genotype of GNAS1 gene.
Conclusion. The dependence of these parameters on Arg389Gly polymorphism of ADRβ1 gene was not found.
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