The relationship between the level of markers of fibrosis ST2, galectin-3, structural, functional parameters of the left ventricle and renal function in patients with ischemic chronic heart failure

Authors

DOI:

https://doi.org/10.14739/2310-1210.2014.5.28742

Keywords:

heart failure, biomarkers, renal function

Abstract

Aim. The aim of the study was to investigate the interrelationships between the new markers of fibrosis, inflammation, parameters of structural and functional state of the left ventricle and renal function in 110 patients with chronic ischemic heart failure.

Methods and results. It was found that in patients with chronic ischemic heart failure with reduced ejection fraction compared with the group with preserved ejection fraction higher levels of NT-proBNP, galectin-3, ST2, cystatin C were revealed.

Conclusion. Direct correlation between level of the cystatin C and new fibrosis markers (galectin-3, ST2) was detected. In patients with preserved ejection fraction cystatin C had direct correlation with indicators of structural and functional remodeling of the left ventricle (LAVi, LVEDV, RVPs) and reverse with renal function.

 

References

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How to Cite

1.
Syvolap VD, Lashkul DA. The relationship between the level of markers of fibrosis ST2, galectin-3, structural, functional parameters of the left ventricle and renal function in patients with ischemic chronic heart failure. Zaporozhye Medical Journal [Internet]. 2014Oct.20 [cited 2024Nov.13];16(5). Available from: http://zmj.zsmu.edu.ua/article/view/28742

Issue

No. 5 (2014): Zaporozhye medical journal

Section

Original research

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