Diagnostic value of AATs to β1- AR in elderly patients with chronic heart failure
DOI:
https://doi.org/10.14739/2310-1210.2014.5.28743Keywords:
Autoantibodies, Chronic Heart Failure, Adrenergic Receptor, Chronic Heart DiseaseAbstract
Aim. To study the deterioration of myocardial contractility in ischemic heart diseases.
Methods and results. We have examined 98 patients aged 69.5±7.9 years, including 65 people with coronary heart disease: stable tension angina EFII-III,CH IIA-IIB degree and 33patients without heart failure with preserved left ventricular ejection fraction (EF> 45%). At the initial stage all patients underwent VLP registration, echocardiography, and also testing the level of cardiotropic AABs using ELISA immunoassay. The levels of AABs to β1-AR, Com-02, Cos-05, L-myosin. Thus, in the group with elevated systolic myocardial dysfunction a high AAB titer to β1-AR was detected in 68.5% of patients, while in the group with normal left ventricular ejection fraction, only in 34.2%.
Conclusions. Thus, the obtained data suggest that the deterioration of myocardial contractility in ischemic heart diseases is associated with an increased titer of β1-AR.
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