Comparative analysis of content of the matrix metalloproteinase-9 in patients with acute cerebral strokes of different types
DOI:
https://doi.org/10.14739/2310-1210.2014.5.28770Keywords:
stroke, matrix metalloproteinase-9Abstract
Aim. It was conducted a comparative determination of matrix metalloproteinase- 9 in 116 patients with ischemic cerebral infarction, hemorrhagic stroke, ischemic stroke with hemorrhagic transformation in patients with circulatory encephalopathy.
Methods and results. The study determined that the concentration of MMP-9 in patients with hemorrhagic stroke and ischemic stroke with hemorrhagic transformation is higher than in patients with ischemic stroke.
Conclusion. It was determined that in patients with ischemic stroke , in which MMP- 9 is below 50 ng / ml , hemorrhagic transformation were not observed regardless of the severity of the condition and volume of the lesion.
References
Berezin, A. E., & Lisovaya, O. A. (2011). Biologicheskie markery kardiovaskulyarnogo riska u pacientov, pereneshikh mozgovoj ishemicheskij insul't: prognosticheskaya cennost' S-reaktivnogo proteina [Biological markers of cardiovascular risk in patients after cerebral ischemic stroke: predictive value of C-reactive protein]. Zaporozhskij medicinskij zhurnal, 5(13), 97–102. [in Ukrainain].
Berezin, A. E., & Samura, T. A. (2012). Prognosticheskij potencial matriksnoj metalloproteinazy-3, matriksnoj metalloproteinazy-9 i mozgovogo natriyureticheskogo peptida u pacientov, perenesshikh Q-infarkt miokarda [Prognostic value of matrix metalloproteinase_3, matrix metalloproteinase-9a nd brain natriuretic peptide in patients after Q-wave myocardial infarction]. Ukrainskyi terapevtychnii zhurnal, 1, 43–51. [in Ukrainain].
Voloshyn, P. V., Mishchenko, T. S., Lekomtseva, Ye. V. (2006). Analiz poshyrenosti ta zakhvoriuvanosti na nervovi khvoroby v Ukraini [Analysis of the prevalence and incidence of nervous diseases in Ukraine]. Mezhdunarodnyj nevrologicheskij zhurnal, 3(7), 9–13. [in Ukrainain].
Konstantinova, E. V. (2013) Sravnitel'noe izuchenie mekhanizmov realizacii ishemicheskogo povrezhdeniya u bol'nykh s infarktom miokarda i s ishemicheskim aterotromboticheskim insul'tom (Avtoref. dis… dokt. med. nauk) [A comparative study of implementation mechanisms of ischemic injury in patients with myocardial infarction and ischemic atherothrombotic stroke. Dr. med. sci. diss. Dr. med. sci. diss.]. Moscow. [in Russian].
Mishchenko, T. S. (2013) Oslozhneniya vosstanovitel'nogo perioda ishemicheskogo insul'ta [Oslozhneniya vosstanovitelnoho perioda ishemicheskoho insulta [Complications of recovery period of ischemic stroke]. Osnovnye napravleniya farmakoterapii v nevrologii; Proceedings of the 15th International Conference. Sudak. [in Russian].
Shurdumova, M. Kh. (2011). Issledovanie immunnovospalitel'nykh markerov razvitiya aterotromboticheskogo ishemicheskogo insul'ta i mekhanizmov realizacii ishemicheskogo povrezhdeniya golovnogo mozga (Avtoref. dis… dokt. med. nauk) [Investigation immunoinflammatory markers of atherothrombotic ischemic stroke and implementation mechanisms of ischemic brain damage. Dr. med. sci. diss.]. Moscow. [in Russian].
Castellanos, M., Leira, R., Serena, J., Pumar, J. M., Lizasoain, I., Castillo, J., & Dávalos, A. (2003). Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke, 34, 40–46. doi: 10.1161/01.STR.0000046764.57344.31.
Chang, D. I., Hosomi, N., Lucero, J., Heo, J. H., Abumiya, T., Mazar, A.P., & del Zoppo, G. J. (2003). Activation systems for latent matrix metalloproteinase-2 are upregulated immediately after focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism, 12(23), 1408–1419. doi: 10.1097/01.WCB.0000091765.61714.30.
Mori, S., Gibson, G., & McTiernan, C. F. (2006). Differential expression of MMPs and TIMPs in moderate and severe heart failure in a transgenic model. J. Card. Fail., 12, 314–325. doi: 10.1016/j.cardfail.2006.01.009.
Park, K. P., Rosell, A., Foerch, C., Xing, C., Kim, W. J., Lee, S., et al. (2009). Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke, 40(8), 2836–2842. doi: 10.1161/STROKEAHA.109.554824.
Reynolds, M. A., Kirchick, H. J., Dahlen, J. R. Anderberg, J. M., McPherson, P. H., Nakamura, K. K., et al. (2003). Early biomarkers of stroke. Clinical Chemistry, 49, 1733–1739.
Romanic, A. M., Burns-Kurtis, C. L., Gout, B. Berrebi-Bertrand, I., & Ohlstein, E. H. (2001). Matrix metalloproteinase expression in cardiac myocytes following myocardial infarction in the rabbit. Life Sciences, 68, 799–814. doi: 10.1016/S0024-3205(00)00982-6.
Silva, G., & Furie, K. (2009). Biomarkers in neurology. Front. Neurol. Neurosci., 25, 55–61.
Thom, T., Haase, N., Rosamond, W., et al. (2006). Heart disease and stroke statistics – 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation, 113, 85–151. doi: 10.1161/CIRCULATIONAHA.105.171600.
Van den Borne, S. W., Cleutjens, J. P., Hanemaaijer, R., Creemers, E. E., Smits, J. F., Daemen, M. J., & Blankesteijn, W. M. (2009). Increased matrix metalloproteinase 8 and 9 activity in patients with infarct rupture after myocardial infarction. Cardiovascular Pathology, 18, 37–43. doi: 10.1016/j.carpath.2007.12.012.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)