Comparative analysis of content of the matrix metalloproteinase-9 in patients with acute cerebral strokes of different types

Authors

  • E. V. Baranova

DOI:

https://doi.org/10.14739/2310-1210.2014.5.28770

Keywords:

stroke, matrix metalloproteinase-9

Abstract

Aim. It was conducted a comparative determination of matrix metalloproteinase- 9 in 116 patients with ischemic cerebral infarction, hemorrhagic stroke, ischemic stroke with hemorrhagic transformation in patients with circulatory encephalopathy.

Methods and results. The study determined that the concentration of MMP-9 in patients with hemorrhagic stroke and ischemic stroke with hemorrhagic transformation is higher than in patients with ischemic stroke.

Conclusion. It was determined that in patients with ischemic stroke , in which MMP- 9 is below 50 ng / ml , hemorrhagic transformation were not observed regardless of the severity of the condition and volume of the lesion.

References

Berezin, A. E., & Lisovaya, O. A. (2011). Biologicheskie markery kardiovaskulyarnogo riska u pacientov, pereneshikh mozgovoj ishemicheskij insul't: prognosticheskaya cennost' S-reaktivnogo proteina [Biological markers of cardiovascular risk in patients after cerebral ischemic stroke: predictive value of C-reactive protein]. Zaporozhskij medicinskij zhurnal, 5(13), 97–102. [in Ukrainain].

Berezin, A. E., & Samura, T. A. (2012). Prognosticheskij potencial matriksnoj metalloproteinazy-3, matriksnoj metalloproteinazy-9 i mozgovogo natriyureticheskogo peptida u pacientov, perenesshikh Q-infarkt miokarda [Prognostic value of matrix metalloproteinase_3, matrix metalloproteinase-9a nd brain natriuretic peptide in patients after Q-wave myocardial infarction]. Ukrainskyi terapevtychnii zhurnal, 1, 43–51. [in Ukrainain].

Voloshyn, P. V., Mishchenko, T. S., Lekomtseva, Ye. V. (2006). Analiz poshyrenosti ta zakhvoriuvanosti na nervovi khvoroby v Ukraini [Analysis of the prevalence and incidence of nervous diseases in Ukraine]. Mezhdunarodnyj nevrologicheskij zhurnal, 3(7), 9–13. [in Ukrainain].

Konstantinova, E. V. (2013) Sravnitel'noe izuchenie mekhanizmov realizacii ishemicheskogo povrezhdeniya u bol'nykh s infarktom miokarda i s ishemicheskim aterotromboticheskim insul'tom (Avtoref. dis… dokt. med. nauk) [A comparative study of implementation mechanisms of ischemic injury in patients with myocardial infarction and ischemic atherothrombotic stroke. Dr. med. sci. diss. Dr. med. sci. diss.]. Moscow. [in Russian].

Mishchenko, T. S. (2013) Oslozhneniya vosstanovitel'nogo perioda ishemicheskogo insul'ta [Oslozhneniya vosstanovitelnoho perioda ishemicheskoho insulta [Complications of recovery period of ischemic stroke]. Osnovnye napravleniya farmakoterapii v nevrologii; Proceedings of the 15th International Conference. Sudak. [in Russian].

Shurdumova, M. Kh. (2011). Issledovanie immunnovospalitel'nykh markerov razvitiya aterotromboticheskogo ishemicheskogo insul'ta i mekhanizmov realizacii ishemicheskogo povrezhdeniya golovnogo mozga (Avtoref. dis… dokt. med. nauk) [Investigation immunoinflammatory markers of atherothrombotic ischemic stroke and implementation mechanisms of ischemic brain damage. Dr. med. sci. diss.]. Moscow. [in Russian].

Castellanos, M., Leira, R., Serena, J., Pumar, J. M., Lizasoain, I., Castillo, J., & Dávalos, A. (2003). Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke, 34, 40–46. doi: 10.1161/01.STR.0000046764.57344.31.

Chang, D. I., Hosomi, N., Lucero, J., Heo, J. H., Abumiya, T., Mazar, A.P., & del Zoppo, G. J. (2003). Activation systems for latent matrix metalloproteinase-2 are upregulated immediately after focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism, 12(23), 1408–1419. doi: 10.1097/01.WCB.0000091765.61714.30.

Mori, S., Gibson, G., & McTiernan, C. F. (2006). Differential expression of MMPs and TIMPs in moderate and severe heart failure in a transgenic model. J. Card. Fail., 12, 314–325. doi: 10.1016/j.cardfail.2006.01.009.

Park, K. P., Rosell, A., Foerch, C., Xing, C., Kim, W. J., Lee, S., et al. (2009). Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke, 40(8), 2836–2842. doi: 10.1161/STROKEAHA.109.554824.

Reynolds, M. A., Kirchick, H. J., Dahlen, J. R. Anderberg, J. M., McPherson, P. H., Nakamura, K. K., et al. (2003). Early biomarkers of stroke. Clinical Chemistry, 49, 1733–1739.

Romanic, A. M., Burns-Kurtis, C. L., Gout, B. Berrebi-Bertrand, I., & Ohlstein, E. H. (2001). Matrix metalloproteinase expression in cardiac myocytes following myocardial infarction in the rabbit. Life Sciences, 68, 799–814. doi: 10.1016/S0024-3205(00)00982-6.

Silva, G., & Furie, K. (2009). Biomarkers in neurology. Front. Neurol. Neurosci., 25, 55–61.

Thom, T., Haase, N., Rosamond, W., et al. (2006). Heart disease and stroke statistics – 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation, 113, 85–151. doi: 10.1161/CIRCULATIONAHA.105.171600.

Van den Borne, S. W., Cleutjens, J. P., Hanemaaijer, R., Creemers, E. E., Smits, J. F., Daemen, M. J., & Blankesteijn, W. M. (2009). Increased matrix metalloproteinase 8 and 9 activity in patients with infarct rupture after myocardial infarction. Cardiovascular Pathology, 18, 37–43. doi: 10.1016/j.carpath.2007.12.012.

How to Cite

1.
Baranova EV. Comparative analysis of content of the matrix metalloproteinase-9 in patients with acute cerebral strokes of different types. Zaporozhye Medical Journal [Internet]. 2014Oct.20 [cited 2024Nov.13];16(5). Available from: http://zmj.zsmu.edu.ua/article/view/28770

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Section

Original research