Impact of genetic and acquired forms of hyperhomocysteinemia on development of complications in preeclampsia
DOI:
https://doi.org/10.14739/2310-1210.2014.5.29128Keywords:
Preeclampsia, Hyperhomocysteinemia, Genetic Polymorphism, ComplicationsAbstract
Aim. High frequency of preeclampsia and the severity of associated complications make this problem actual. In order to determine the role of MTHFR gene polymorphisms and hyperhomocysteinemia in the development of obstetric and perinatal complications in preeclampsia, 133 pregnant women have been examined in terms of homocysteine concentration and analyzed for the presence of MTHFR 677 C→T gene polymorphisms.
Methods and results. It has been established that the probability of obstetric and perinatal complications in pregnant women with preeclampsia is significantly increased in the presence of hyperhomocysteinemia.
Conclusion. One of the reasons for the increased homocysteine concentration in the blood serum is mutation of MTHFR 677TT.
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