Study of vinpocetine intranasal dosage form consistence properties
DOI:
https://doi.org/10.14739/2310-1210.2014.5.29149Keywords:
Vinpocetine, Intranasal Drug Administration, Rheology, «Mechanical Stability»Abstract
Aim. Study of structural-mechanical nasal semisolid dosage forms on emulsion bases providing with optimal release active substance was done.
Methods and results. Established vinpocetine nasal creams rheologic properties showed them as thixotropic systems. Restoration after stress removal is cuased by their structure coagulation bonds. Their consistent properties are completely situated within rheologic optimum of consistence limits.
Conclusion. Analysis of rheograms of flow allowed to reveal compositions of vinpocetine nasal emulsion ointments with optimal consistent properties and selected for the next preclinical investigations.
References
Rybachuk, V. D., Trutaiev, I. V., & Yehorov, I. A. (2005) Vyvchennia reolohichnykh vlastyvostei novoi kombinovanoi mazi dlia likuvannia alerhichnyhk dermatytiv [Studying of rheological behaviour of the new combined ointment for treatment allergic dermatit]. Visnyk farmatsii, 3(43), 32–34. [in Ukrainian].
Hrytsenko, V. I., Chuieshov, V. I., & Ruban, O. A. (2004) Rozrobka matematychnoi modeli reolohichnyhk parametriv polietylenoksydnoi osnovy [Working out of a mathematical model of rheological parametres polyetilenoxed bases]. Farmatsevtychnyi zhurnal, 5, 81–84. [in Ukrainian].
Kryklyva, I. O., Ruban, O. A., & Chuieshov, V. I. (2002) Vyvchennia strukturno-mehkanichnyhk vlastyvostei novoi kombinovanoi mazi z kseroformom [Studying of structurally-mechanical characteristics new combined ointment with хеrоfорм]. Visnyk farmatsii, 2(30), 14–16. [in Ukrainian].
Percev, I. M., Kotenko, A. M., Chueshov, V. I., & Khaleeva, E. L. (2003). Farmacevticheskie i biologicheskie aspekty mazej [Pharmaceutical and biological aspects of ointments]. Kharkov: Zolotye stranicy. [in Ukrainian].
Dyudyun, A. D., Gladyshev, V. V., & Nagornyj, V. V. (2002) Optimizaciya metodologii biofarmacevticheskikh issledovanij pri razrabotke tekhnologii myagkikh lekarstvennykh form dlya terapii dermatomikozov [Optimisation of methodology of biopharmaceutical researches by working out of technology of soft medicinal forms for therapy dermatomycoses]. Dermatovenerolohiia, kosmetolohiia, seksopatolohiia, 1-2(5), 13–16. [in Ukrainian].
Gladyshev, V. V., Nagornyj, V. V., Brazhko, A. A, & Golovkin, V. V. (2002) Optimizaciya metodologii biofarmacevticheskikh issledovanij pri razrabotke tekhnologii parafarmacevticheskikh sistem [Optimisation of methodology of biopharmaceutical researches by working out of technology of parapharmaceutical systems]. Visnyk Zaporizkoho derzhavnoho universytetu, 1, 158–161. [in Ukrainian].
Chernij, V. I., Kolesnikov, A. N., Gorodnik, H. A., & Savchenko, A. A. (2007). Ishemiya golovnogo mozga v medicine kriticheskikh sostoyanij. Nejroprotekciya (patofiziologiya, terminologiya, kharakteristika preparatov) [Brain ischemia in medicine of critical states. Neuroprotection (physiopathology, terminology, the characteristic of drugs)]. Kiev: Zdorov`a. [in Ukrainian].
Belenichev, I. F., Chernii, V. I., Kolesnik, Yu. M., & Pavlov, S. V. (2009). Racional'naya nejroprotekciya [Rational neuroprotection]. Doneck: Isdatel Zaslavskij A. Yu. [in Ukrainian].
Rumyantseva, S. A., Afanas`ev, V. V., Kuz`mina, Yu. V., & Silina, E. V. (2010). Racional'naya farmakokorrekciya porazhenij mozga pri ostroj i khronicheskoj ishemii [Rational pharmacological correction of lesions of a brain at a sharp and chronic ischemia]. Consilium Medicum, 12(9). 23–31. [in Russian].
Nahorna, N. O., Hladyshev, V. V., Burlaka, B. S., Kechin, I. L. (2014). Vyvchennia vplyvu osnov-nosiiv na intensyvnist vyvilnennia vinpotsetynu z nazalnych miakyhk likarskykh form [Studying of influence of bases-carriers on intensity of liberation vinpоcеtin from nasal soft medicinal forms]. Farmatsevtychnyi zhurnal, 2, 64–67. [in Ukrainian].
Hladyshev, V. V. (1997). Teoreticheskoe i e`ksperimental'noe obosnovanie sozdaniya myagkikh lekarstvennykh form antimikoticheskogo dejstviya (Dis… dokt. med. nauk). [Theoretical and experimental substantiation of building of soft medicinal forms antimycotic actions: the dissertation of the doctor of pharmaceutical sciences. Dr. med. sci. diss.]. Zaporozhye. [in Ukrainian].
Tencova, A. I., Greckij, V. M. (1980). Sovremennye aspekty issledovaniya i proizvodstva mazej [Modern aspects of research and production of ointments]. Moscow: Medicina. [in Russian].
Arkusha, A. A. (1982). Issledovanie strukturno-mekhanicheskikh svojstv mazej s cel'yu opredeleniya optimuma konsistencii (Avtoref. dis…kand. med. nauk). [Research structurally-mechanical characteristics ointments for the purpose of definition of an optimum of a consistence: the dissertation autoabstract on competition of a scientific degree of the candidate of pharmaceutical sciences]. (Extended abstract of candidate’s thesis). Kharkov. [in Ukrainian].
Golovkin, V. V., Golovkin, V. A., & Gladyshev, V. V. (2001). Strukturno-mekhanicheskie svojstva osnov-nositelej, ikh regulirovanie i znachenie dlya vaginal'nykh preparatov [Structurally-mechanical properties of bases-carriers, their regulation and value for vaginalis drugs]. Zaporozhskij medicinskij zhurnal, 1–2. 64–67. [in Ukrainian].
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