Study of vinpocetine intranasal dosage form consistence properties
DOI:
https://doi.org/10.14739/2310-1210.2014.5.29149Keywords:
Vinpocetine, Intranasal Drug Administration, Rheology, «Mechanical Stability»Abstract
Aim. Study of structural-mechanical nasal semisolid dosage forms on emulsion bases providing with optimal release active substance was done.
Methods and results. Established vinpocetine nasal creams rheologic properties showed them as thixotropic systems. Restoration after stress removal is cuased by their structure coagulation bonds. Their consistent properties are completely situated within rheologic optimum of consistence limits.
Conclusion. Analysis of rheograms of flow allowed to reveal compositions of vinpocetine nasal emulsion ointments with optimal consistent properties and selected for the next preclinical investigations.
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