Speckle tracking echocardiography in hypertensive males with glucose metabolism disorders
DOI:
https://doi.org/10.14739/2310-1210.2014.6.35634Keywords:
Hypertension, Type 2 Diabetes Mellitus, Glucose Metabolism Disorders, EchocardiographyAbstract
Aim. Early left ventricle (LV) abnormalities are hardly detectable by means of standard echocardiography in patients with hypertension (HTN) and glucose metabolism disorders. The objective of this study was to assess changes inLVfunction with speckle tracking echocardiography in hypertensive males with different types of glucose metabolism abnormalities.
Methods and results. We recruited 158 hypertensive males with different glycemic status. The multidirectionalLVstrain was assessed by two-dimensional speckle tracking echocardiography. The patients with HTN and type 2 diabetes mellitus demonstrated significant reduction ofLVglobal longitudinal strain and early diastolic strain rate despite preservedLVejection fraction.
Conclusion. Speckle tracking echocardiography can identify subclinical myocardial alterations in hypertensive males with glucose metabolism abnormalities.
References
Danaei G., Finucane M., Lu Y., Singh G., Cowan M., Paciorek C., Lin J., et al. (2011). National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2•7 million participants. Lancet, 378 (9785), 31-40. doi: 10.1016/S0140-6736(11)60679-X.
Kearney P., Whelton M., Reynolds K., Muntner P., Whelton P., He J. (2005). Global burden of hypertension: analysis of worldwide data. Lancet, 365 (9455), 217-223. doi:10.1016/S0140-6736(05)17741-1.
Lopez-Jaramillo P., Lopez-Lopez J., Lopez-Lopez C., Rodriguez-Alvarez M. (2014). The goal of blood pressure in the hypertensive patient with diabetes is defined: now the challenge is go from recommendations to practice. Diabetol Metab Syndr. 6 (1), 31. doi: 10.1186/1758-5996-6-31.
Li R.J., Yang J., Yang Y., Ma N., Jiang B., Sun Q.W., et al. (2014). Speckle tracking echocardiography in the diagnosis of early left ventricular systolic dysfunction in type II diabetic mice. BMC Cardiovasc Disord. 8 (14), 141. doi: 10.1186/1471-2261-14-141.
Di Bonito P., Moio N., Cavuto L., Covino G., Murena E., Scilla C., et al. (2005). Early detection of diabetic cardiomyopathy: usefulness of tissue Doppler imaging. Diabet Med. 22 (12), 1720-1725. doi: 10.1111/j.1464-5491.2005.01685.x.
Hoehn K., Salmon A., Hohnen-Behrens C., Turner N., Hoy A., Maghzal G.J, et al. (2009). Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci USA. 106 (42), 17787-17892. doi: 10.1073/pnas.0902380106.
Ng K., Allen M., Desai A., Macrae D., Pathan N. (2012). Cardioprotective effects of insulin: how intensive insulin therapy may benefit cardiac surgery patients. Circulation. 125 (5), 721-728. doi:10.1161/CIRCULATIONAHA.111.063784.
Dinh W., Lankisch M., Nickl W., Scheyer D., Scheffold T., Kramer F., et al. (2010). Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study. Cardiovasc Diabetol 9, 63. doi: 10.1186/1475-2840-9-63.
Rutter M., Parise H., Benjamin E., Levy D., Larson M., Meigs J., et al. (2003). Impact of glucose intolerance and insulin resistance on cardiac structure and function: sex-related differences in the Framingham Heart Study. Circulation, 107(3), 448-454. doi: 10.1161/01.CIR.0000045671.62860.98.
Cadeddu C., Nocco S., Piano D., Deidda M., Cossu E., Baroni M., et al. (2013). Early impairment of contractility reserve in patients with insulin resistance in comparison with healthy subjects. Cardiovasc Diabetol, 12, 66. doi: 10.1186/1475-2840-12-66.
Nakai H., Takeuchi M., Nishikage T., Lang R., Otsuji Y. (2009). Subclinical left ventricular dysfunction in asymptomatic diabetic patients assessed by two-dimensional speckle tracking echocardiography: correlation with diabetic duration. Eur J Echocardiogr, 10 (8), 926-932. doi: 10.1093/ejechocard/jep097.
Roos C., Scholte A., Kharagjitsingh A., Bax J., Delgado V. (2014). Changes in multidirectional LV strain in asymptomatic patients with type 2 diabetes mellitus: a 2-year follow-up study. Eur Heart J Cardiovasc Imaging, 15(1), 41-47. doi: 10.1093/ehjci/jet075.
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