Changes in the extracellular matrix under the influence of anticoagulant therapy in patients with Q-myocardial infarction after thrombolysis
DOI:
https://doi.org/10.14739/2310-1210.2014.6.35656Keywords:
Myocardial Infarction, Matrix Metalloproteinase-9, Tissue Inhibitor Of Metalloproteinase-1Abstract
Aim. Matrix metalloproteinases play a key role in adaptive postinfarction remodeling of the heart. In order to study the influence of anticoagulation therapy on the state of matrix metalloproteinases and their inhibitors, the incidence of post-infarction aneurysm and thrombus formation in the left ventricle of patients with Q-wave myocardial infarction after thrombolytic therapy was studied.
Methods and results. 97 patients took part in the study. Serum levels of matrix metalloproteinases and their inhibitors were evaluated by immunoassay analysis. Echocardiography was used for remodeling, systolic and diastolic function of the heart evaluation.
Conclusion. Under the influence of the treatment reduction in the intensity of the degradation of connective tissue matrix of the myocardium was showed. That was accompanied by improvement in left ventricular systolic function and transformation of diastolic dysfunction into a pseudonormal type.
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