DIAGNOSTIC VALUE OF BRAIN DAMAGE MARKERS LEVELS IN SERUM DURING THE FIRST 24 HOURS OF THE BRAIN ISCHEMIC STROKE

Authors

  • Y. N. Neryanova

DOI:

https://doi.org/10.14739/2310-1210.2014.6.35764

Keywords:

Brain Ischemic Stroke, Acute Period, Neuron Specific Enolase, Myelin Basic Protein, S100 Protein

Abstract

 Aim. To determine the brain damage markers levels in serum during the first 24 hours of the brain ischemic stroke.

Methods and results.115 patients in acute period of brain ischemic stroke were examined.

Conclusion. It was established that development of brain ischemic stroke is followed by increase of serum level of neuronspecificenolase(Δ%=1010; p<0,05), myelin basic protein (Δ%=440; p<0,05) and S100 protein (Δ%=310; p<0,05) in the first 24 hours of disease onset. 

References

Barbieri, A., Giuliani, E., Carone, C., et al. (2013). Clinical severity of ischemic stroke and neural damage biomarkers in the acute setting: the stroke Markers (STROMA) study.MinervaAnestesiol, 79(7), 750–757.

Zaheer, S., Beg, M.,Rizvi, I., et al. (2012).Correlation between serum neuron specific enolase and functional neurological outcome in patients of acute ischemic stroke.Indian J ClinBiochem, 27(2), 186–190.

Bharosay, A., Bharosay, V. V.,Varma, M., et al. (2013).Correlation of brain biomarker neuron specific enolase (NSE) with degree of disability and neurological worsening in cerebrovascular stroke.Ann Indian AcadNeurolVol., 16(4), 504–508.

Gilhus, N. E. (2011). European Handbook of Neurological Management: Volume 1, 2nd Edition.Blackwell Publishing Ltd.

Petzold,A.,Michel, P., Stock, M., et al. (2008). Glial and axonal body fluid biomarkers are related to infarct volume, severity, and outcome.CerebrovascDisVol, 17(4), 196–203.doi: 10.1016/j.jstrokecerebrovasdis.2008.02.002.

Mukherjee, D., &Patil, C.G. (2011). Epidemiology and the global burden of stroke.WorldNeurosurg., 76(6), 85–90.doi: 10.1016/j.wneu.2011.07.023.

Brouns, R.,DeVil, B., Cras, P., et al. (2010).Neurobiochemical markers of brain damage in cerebrospinal fluid of acute ischemic stroke patients.Clin Chem., 56(3), 451–458.doi: 10.1373/clinchem.2009.134122.

Hjalmarsson, C.,Bjerke, M., Andersson, B., et al. (2014).Neuronal and glia-related biomarkers in cerebrospinal fluid of patients with acute ischemic stroke.J Cent NervSyst Dis, 19(6), 51–58.doi: 10.4137/JCNSD.S13821.

Purrucker, J. C., Herrmann, O., Lutsch, J. K., et al. (2014). Serum protein S100β is a diagnostic biomarker for distinguishing posterior circulation stroke from vertigo of nonvascular causes. EurNeurol, 16(72), 278–284.

How to Cite

1.
Neryanova YN. DIAGNOSTIC VALUE OF BRAIN DAMAGE MARKERS LEVELS IN SERUM DURING THE FIRST 24 HOURS OF THE BRAIN ISCHEMIC STROKE. Zaporozhye medical journal [Internet]. 2014Dec.8 [cited 2024Mar.29];(6). Available from: http://zmj.zsmu.edu.ua/article/view/35764

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Section

Original research