Features of immunophenotype of pancreatic ductal adenocarcinoma

Authors

DOI:

https://doi.org/10.14739/2310-1210.2014.6.35867

Keywords:

Pancreatic Cancer, Immunohistochemistry

Abstract

Aim. To determine features of immunophenotype of pancreatic ductal adenocarcinoma.

Methods and results. At the immunohistochemical research of biopsy and postoperative material of 120 patients with pancreatic ductal adenocarcinoma the expression levels of diagnostic markers of ductal-genesis cancer were made.

Conclusion. There were shown features of immunohistochemical pattern of cytokeratins and oncoproteins expression in malignant structures of tumor, in PanIN foci, in reactive-changed ductules and in normal pancreatic tissue.  Expediency of use of the immunohistochemical panel of markers to cytokeratins 7, 17, 18, 19 and 20, oncoproteins CEA, CA 125, CA 19-9 and pancreatic polypeptide for verification and differential diagnostics of pancreatic ductal adenocarcinoma is shown, and also the minimum diagnostic panel which includes CK7/19, CK20, CEA and PP is certain.

References

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Tuffaha, M., Gichka, S., & Guski, H. (2013). Immunogistokhimicheskaya diagnostika opukholej [Immunohistochemical diagnosis of tumors]. Kyiv: Intermed. [in Ukrainian].

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Duvel, J. V., Savas, L., & Banner, B. F. (2000). Expression of cytokeratins 7 and 20 in carcinomas of the extrahepatic biliary tract, pancreas and gallbladder. Arch. Pathol. Lab. Med, 124, 1196–1200. doi: 10.1043/0003-9985(2000)124<1196:EOCAIC>2.0.CO;2.

Neoptolemos, J. P., Urrutia, R., Abbruzzese, J. L., & Büchler, M. W. (Eds.) (2010). Pancreatic Cancer. Springer Science+Business Media, LLC.

Klöppel, G., Hruban, R.H., Longnecker, D.S., et al. (2000). Tumours of the exocrine pancreas. World Health Organization Classification of Tumours-Pathology and Genetics of Tumours of the Digestive System. S. Hamilton, L.A. Aaltonen (Eds.). (pp. 219–305). Lyon: IARC Press.

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How to Cite

1.
Evseyev AV. Features of immunophenotype of pancreatic ductal adenocarcinoma. Zaporozhye Medical Journal [Internet]. 2014Dec.8 [cited 2024Nov.23];16(6). Available from: http://zmj.zsmu.edu.ua/article/view/35867

Issue

No. 6 (2014): Zaporozhye medical journal

Section

Original research

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