Сytomegalovirus infection as a pathology predictor in fetuses, newborns and children of early age

Authors

  • О. О. Kulia

DOI:

https://doi.org/10.14739/2310-1210.2014.6.35870

Keywords:

Newborns, Cytomegalovirus Infection, Diagnostics and Treatment

Abstract

Aim. The relevance of cytomegaloviral infection is caused by perinatal loss and disorders of varying severity. The specialized literature has been reviewed in order to compile and present a modern view on the etiology, possible pathogenetic mechanisms, to describe the main clinical symptoms, the current strategy of diagnosis, treatment and prevention of cytomegalovirus infection of infants.

Methods and results. It’s been established that a variety of clinical manifestations are associated with the ability of the virus to replicate in all cells of the body.  The serological survey and  the polymerase reaction are used for diagnosis.

 Conclusion. While  treating infants the effectiveness of specific immunoglobulin is demonstrated. Prevention involves hygiene standards, administration of specific hyper immune immunoglobulin and vaccination.

References

Vovk, L. M. (2011). Rol osnovnykh predstavnykiv TORCH-kompleksu v rozvytku perynatalnoi patolohii [The role of the main representatives of TORCH-complex of perinatal pathology]. Klinichna imunolohiia. Alerholohiia. Infektolohiia, (5), 25–29. [in Ukrainian].

Drannik, G. N. (2010) Klinicheskaya immunologiya i allergologiya [Clinical Immunology and Allergology]. Kyiv. [in Ukrainian].

Znamenska, T. K., Shvets, H. I., & Poiarcova, O. A. (2009). Novi pidkhody do likuvannia novonarodzhenykh ditei vid materiv z herpesvirusnoiu ta tsytomehalovirusnoiu infektsiiamy [New approaches to the treatment of newborns from mothers with herpes virus and cytomegalovirus infections]. Perinatologiya i pediatriya, 2(38), 40–45. [in Ukrainian].

Znamenska, T. K., Zhdanovych, O. I., Pysariev, А. О., Shvets, H. I., Bilenka, O. V., Sribna, V. Ye., & Kolomiichenko, T. V. (2010). Vplyv TORCH-infektsii u materi na perebih periodu rannoi neonatalnoi adaptatsii [Effect TORCH-infections in the mother on the course of the period of early neonatal adaptation]. Aktualni pytannia neonatolohii – Current issues of Neonatology: Abstracts of Papers of the 5th Congress of neonatologists Ukraine with international participation. Kyiv. [in Ukrainian].

Kupriyanova, M. N., Lukina N. V., Burseva A. R., et al. (2007). Imunoglobulin protiv citomegalovirusa v terapii vrozhdennoj citomegalovirusnoj infekcii [Cytomegalovirus immunoglobulin in the treatment of congenital cytomegalovirus infection]. Aktual`nye problemy pediatrii Proceedings of the 11th Congress pedyatrov Russia, (pp. 369–370). Moscow: Heotar-Media. [in Russian].

Znamenska, T. K. (2012). Neonatolohiia [Neonatology]. Kyiv: Sofiia. [in Ukrainian].

Plechanova, T. M., Usenko, T. V., Samokhina, I. I., Serdiuk, R. O. (2010). Rezervy rannoi diahnostyky vnutrishnoutrobnykh infektsii [Provisions for early diagnosis of intrauterine infection]. Aktualni pytannia neonatolohii – Current issues of Neonatology: Abstracts of Papers of the 5th Congress of neonatologists Ukraine with international participation. Kyiv. [in Ukrainian].

Pryimak, S. H., Koshuba, I. V., Rypzhuk, V. Ye., & Formaziuk, T. V. (2012). Tsytomehalovirusna infektsiia v strukturi perynatalnykh uskladnen [Cytomegalovirus infection in the structure of perinatal complications]. Aktualni pytannia pediatrii, akusherstva ta hinekolohii, 1, 133–134. [in Ukrainian].

Pryimak, S. H. (2012). Osoblyvosti klinichnoho perebihu tsytomehalovirusnoi infektsii u vahitnykh ta novonarodzhenykh [Features of clinical course of CMV infection in pregnant women and newborns]. Neonatolohiia, khirurhiia ta perynatalna medytsyna, 2, 4(6), 146–148. [in Ukrainian].

Redko, I. I. (2010). Osoblyvosti perebihu perynatalnoho ta neonatalnoho periodu pry vnutrishnoutrobnomu infikuvanniu [Features course of perinatal and neonatal period in intrauterine infection]. Pediatriia, akusherstvo ta hinekolohiia, 71(5), 12–14. [in Ukrainian].

Samokhvalova, A. V. (2013). Osoblyvosti rannoho neonatalnoho periodu u novonarodzhenykh ditei vid materiv z reproduktyvnymy vtratamy ta TORCH-infektsiieiu [Features of early neonatal period in newborns of mothers with reproductive losses and TORCH-infections]. Aktualni pytannia pediatrii, akusherstva ta hinekolohii, 1, 97–99. [in Ukrainian].

Sandulyak, T. V. (2008). Rasprostranennost' perinatal'nykh infekcij u detej do 1 goda s nedifferencirovannoj displaziej soedinitel'noj tkani [The prevalence of perinatal infections in children younger than 1 year with undifferentiated connective tissue dysplasia]. Mezhdunarodnyj nevrologicheskij zhurnal, 5(21), 26–34. [in Ukrainian].

Senatorova, Gh. S., Buzhynska, N. R., & Malich, T. S. (2007). TORCH-infikuvannia u patohenezi retsydyviv obstruktyvnoho bronkhitu u ditei rannoho viku [TORCH-infections in the pathogenesis of recurrence of obstructive bronchitis in infants]. Pediatriia, akusherstvo ta hinekolohiia, 4, 121. [in Ukrainian].

Usacheva, E. V., & Duda, E. A. (2012). Patohenetychne obgruntuvannia spetsyfichnoi imunoterapii vrodzhenoi i rannoi nabutoi tsytomehalii ta otsinka yii efektyvnosti [Pathogenetic substantiation of specific immunotherapy congenital and early acquired cytomegalovirus and its evaluation]. Sovremennaya pediatriya, 1(41), 141–145. [in Ukrainian].

Usacheva E. V. (2014). Alhorytm vedennia infikovanykh tsytomehalovirusom ditei rannoho viku: kliniko-patohenetychne obgruntuvannia [Management algorithm cytomegalovirus infected infants: clinical and pathogenetic substantiation]. Sovremennaya pediatriya, 1(57), 68–74. [in Ukrainian].

Usacheva E. V. (2012). Tsytomehalovirusna infektsiia u vahitnykh i ditei rannoho viku: pidkhody do diahnostyky okremykh form [Cytomegalovirus infection in pregnant women and young children: approaches to diagnosis of certain forms of]. Zaporozhskij medicinskij zhurnal, 5, 69–70. [in Ukrainian].

Fesenko M. Ye., & Meleshchenko O. I. (2012). Zakhvoriuvanist, fizychnyi ta nervovo-psykhichnyi rozvytok ditei z vrodzhenoiu tsytomehalovirusnoiu infektsiieiu [The incidence of physical and neuro-psychological development of children with congenital cytomegalovirus infection]. Sovremennaya pediatriya, 3(43), 42–44. [in Ukrainian].

Yulish, Ye. I., Chernysheva, O. Ye, Samojlenko, I. H., Volosovec, A. P., & Krivopustov, S. P. (2008). Citomegalovirusnaya infekciya u detej [Cytomegalovirus infection in children]. Antimikrobnaya i protivovirusnaya terapiya, 236, 12–19. [in Ukrainian].

Yulish, Ye. I., & Abilova, Ye. I. (2012). Morfostrukturnye sdvigi v organakh i tkanyakh detej rannego vozrasta pri vrozhdennoj generalizovannoj citomegalovirusnoj infekcii [Morphostructural changes in organs and tissues of infants with congenital generalized cytomegalovirus infection]. Neonatolohiia, khirurhiia ta perynatalna medytsyna, 2, 3(5), 113–117. [in Ukrainian].

Yulish Ye. I., Yaroshenko S. Ya. (2010). Chastaya respiratornaya zabolevaemost' detej rannego vozrasta i persistiruyuschaya infekciya [Frequent respiratory morbidity in young children, and persistent infection]. Sovremennaya pediatriya, 3, 44–49. [in Ukrainian].

Adler, S. P., & Nigro, G. (2008). The importance of cytomegalovirus-specific antibodies for the prevention of fetal cytomegalovirus infection or disease. Herpes, 15(2), 24–7.

Tian, C., Asad, Ali S., & Weitkamp, J. H. (2010). Congenital Infections, Part 1: Cytomegalovirus, Toxoplasma, Rubella and Herpes Simplex. NeoReviews, 11(8), 436–446. doi: 10.1542/neo.11-8-e436.

Mishaels, M. G. (2007). Treatment of congenital cytomegalovirus: where are we now? Expert Rev Anti Infect. Ther, 5(3), 441–8. doi: 10.1586/14787210.5.3.441.

Oliver, S. E., Cloud, G. A., & Sanchez, P. J. (2009). National Institute of Allergy, Infectious Diseases Collaborative Antiviral Study Group. Neurodevelopmental outcomes following ganciclovir therapy in cymptomatic congenital cytomegalovirus infections involving the central nervous system. J. Clin. Virol, 46 (4), 22–26. doi: 10.1016/j.jcv.2009.08.012.

Polin, R. A., & Lorenz, J. M. (Eds.). (2008). Neonatology. New York, NY: Cambridge University Press.

Shet, A. (2011). Congenital and perinatal infections: throwing new light with an old TORCH. Indian J. Pediatr, 78(1), 88–95. doi: 10.1007/s12098-010-0254-3.

Marino, T., Laartz, B., Smith, S. E., Gompf, S. G., Allaboun, K., Marinez, J. E., & Logan, J. L. (2014). Viral Infections and Pregnancy. Medscape, Retrieved from http: // emedicine. medscape.com /235213-overview.

How to Cite

1.
Kulia ОО. Сytomegalovirus infection as a pathology predictor in fetuses, newborns and children of early age. Zaporozhye medical journal [Internet]. 2014Dec.8 [cited 2024Apr.26];16(6). Available from: http://zmj.zsmu.edu.ua/article/view/35870