Gender peculiarities and prognostic value of matrix metalloproteinase and their inhibitors system in patients with acute Q-wave left ventricle myocardial infarction

Authors

DOI:

https://doi.org/10.14739/2310-1210.2015.1.38614

Keywords:

Heart Aneurysm, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1

Abstract

Matrix metalloproteinases play a key role in postinfarction remodeling of the heart.

The aim was to study gender and age peculiarities of matrix metalloproteinases and their inhibitors, and determine their prognostic value in post-infarction aneurysm of the left ventricle formation.

Methods and results. 76 patients with Q-wave myocardial infarction was studied by immunoassay analysis serum levels of matrix metalloproteinases and their inhibitors depending on patients sex and age. On the 1st day of the disease higher concentrations of MMP-9 and TIMP-1 were determined in women of elder age group. On the 10th day of the disease, in case of aneurysm formation, as in men, as women of any age, increasing of MMP-9 and decreasing of TIMP-1 levels was determined.

Conclusion. Powerful prognostic potential of MMP-9 and TIMP-1 in post-infarction aneurysm formation was determined especially in women of elder age group.

References

Berezin, A. E., Samura, T. A. (2011) Prognosticheskij potencial markerov biomekhanicheskogo stressa u pacientov, perenesshikh Q-infarkt miokarda. Rezul`taty prognosticheskogo odnogodichnogo issledovaniya [Comparison of the prognostic potential of biomechanic stress markers - circulating stromelysin-1, matrix metalloprteinase-9 and N-terminal fragment of brain natriuretic peptide in patients with acute Q-wave myocardial infarction. Results of cohort study]. Ukrainskyi medychnyi chasopys, 6(86), 100–103. [in Ukrainian].

Rogova, L. N., Shesternina, N. V., Zamechnik, T. V., & Fastova, I. A. (2011) Matriksnye metalloproteinazy, ikh rol` v fiziologicheskikh I patologicheskikh processakh [Matrix metalloproteinases, their role in phisiological and pathological processes (Review)]. Vestnik novykh medicinskikh tekhnologij, 18(2), 86–89. [in Russian].

Kovalenko, V. M. & Kornatski, V. M. (Eds) (2014) Khvoroby systemy krovoobihu yak medyko-socialna i suspilno-politychna problema. Analityko-statystychnyi posibnyk [Cardiovascular system diseases as medicine-social and socio-political problem. Analytic-statistical textbook]. Kuiv [In Ukrainian].

Koh, K. K., Ahn, J. Y., Kang, M. H., Kim, D. S, Jin, D. K., Sohn, M. S., et al. (2001) Effects of hormone replacement therapy on plaque stability, inflammation, and fibrinolysis in hypertensive or overweight postmenopausal women. Am. J. Cardiol., 88, 1423–1426. doi: http://dx.doi.org/10.1016/S0002-9149(01)02126-9.

Spinale, F. G. (2007) Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol. Rev., 4(87), 1285–1342. doi: 10.1152/physrev.00012.2007.

Tanindi, A., Sahinrslan, A., Elbeg, S., & Cemri, M. (2011) Relationship between MMP-1, MMP-9, TIMP-1, IL-6 and risk factors, clinical presentations, extent and severity of atherosclerotic coronary artery disease. Open Crdiovasc Med. J., 5, 110–116. doi: 10.2174/1874192401105010110.

West, M. J., Nestel, P. J., Kirby, A. C., Schnabel, R., Sullivan, D., Simes, R. J., at al. (2008) The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study. Eur. Heart J., 29, 923-931. doi: 10.1093/eurheartj/ehn007.

Welsh, P., Whincup, P. H., Papacosta, O., Wannamethee, S. G., Lennon, L., Thomson, A., et al. (2008) Serum matrix metalloproteinase-9 and coronary heart disease: a prospective study in middle-aged men. QJM, 101, 785–791. doi: 10.1093/qjmed/hcn088.

How to Cite

1.
Kyselov SM. Gender peculiarities and prognostic value of matrix metalloproteinase and their inhibitors system in patients with acute Q-wave left ventricle myocardial infarction. Zaporozhye Medical Journal [Internet]. 2015Feb.9 [cited 2024Oct.6];17(1). Available from: http://zmj.zsmu.edu.ua/article/view/38614

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Section

Original research