Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy

Authors

  • O. V. Kuryata
  • M. M. Grechanyk

DOI:

https://doi.org/10.14739/2310-1210.2015.1.38626

Keywords:

Myocardial Ischemia, Non-alcoholic Fatty Liver Disease, Vascular Endothelium

Abstract

Aim. 28 Patients have been observed to examine correlation between functional condition of vascular endothelium, and weight in patients with coronary heart disease in combination with non-alcoholic fatty liver disease and also its dynamics under influence of statin therapy.

Methods and results. In 20 patients endothelium-dependent vasodilation (EDVD) has been detected based on reactive hyperemia and its dynamics depending on the body mass index under the influence of statin therapy.

Conclusion. In patients with ischemic heart disease, obesity and NAFLD first degree expressed positive dynamics on endothelial function (57%) in contrast to patients with overweight (44%) has been revealed during therapy with pitavastatin 2 mg for 8 weeks; besides an increase of hepatic transaminases has not been detected, which means that the abolition of the drug was not required.

References

Bellentani, S., Scaglioli, F. & Marino, M. (2011). Epidemiology of non-alcoholic fatty liver disease. Jаpn. Pharmacol. Ther., 39, 789–803.

Belentani, S., Saccoccio, G., Masutti, F., Crocè, L. S., Brandi, G., Sasso, F., et al. (2000). Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann. Intern. Med. 132, 112–117.

Bugianesi, E. & Gastaldelli, A. (2012). Hepatic and cardiac steatosis: Are they coupled? Heart Fail. Clin, 8, 663–670. doi: 10.1016/j.hfc.2012.06.010.

Mak, K., Bhatt, D., Shao, M., Haffner, S. M., Hamm, C. W., Hankey, G. J., et al. (2009). The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease . Eur. Heart J. 30 (7), 857-865. doi: 10.1093/eurheartj/ehp037.

Bedogni, G., Miglioli, L., Masutti, F., Castiglione, A., Crocè, L. S., Tiribelli, C., & Bellentani, S. (2007). Incidence and natural course of fatty liver in the general population: the Dionysos study. Hepatology, 46(5), 1387–1391.

Sun, L., & Lü, S. Z. (2011). Association between non-alcoholic fatty liver disease and coronary artery disease severity. Chinese. Med. J., 124(6), 867–872.

Dzyak, G. V., Egorov, K. Yu., & Kolesnik, E. L. (2013) Pitavastatin – novyj ingibitor GMG-KoA-reduktazy: osobennosti klinicheskoj farmakologii i perspektivy primeneniya pri lechenii serdechno-sosudistykh zabolevanij [Pitavastatin – a new inhibitor of the HMG-CoA reductase: peculiarities of clinical pharmacology and perspectives of its usage in treatment of cardiovascular diseases]. Medychnі perspektyvy, 4, 36–44. [ in Ukraine].

Campeau, L. (2002). Canadian Cardiovascular Society grading of angina pectoris revisited 30 years later. Canadian Journal of Cardiology, 18(4), 439–442.

Bellentani, S., Pozzat, G., Saccoccio, G., Crovatto, M., Crocè, L. S., Mazzoran, L., et al. (1999). Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study. Gut., 44, 874–880.

Celermajer, D. S. (2007). Endothelial dysfunction: does it matter? It is relevant? J. Am. Coll. Cardiology, 30, 325–333.

Alekseev, V. V. & Karpishchenko, A. I. (2012) Medicinskie laboratornye tehnologii. Rukovodstvo po klinicheskoj laboratornoj diagnostike [Medical laboratory technology. Manual of Clinical Laboratory Diagnostics]. Moscow: GEOTAR-Media. [in Russian].

Lakin, G. F. (1990) Biometriya [Biometrics]. Moscow: Vysshaya shkola. [in Russian].

Downloads

How to Cite

1.
Kuryata OV, Grechanyk MM. Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy. Zaporozhye Medical Journal [Internet]. 2015Feb.9 [cited 2024Nov.13];17(1). Available from: http://zmj.zsmu.edu.ua/article/view/38626

Issue

No. 1 (2015): Zaporozhye Medical Journal

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)