Prognosis of peracute period of brain ischemic aterotrombotic stroke course on the ground of TNF-α serum levels detection in the first day of disease

Authors

  • Yu. N. Neryanova

DOI:

https://doi.org/10.14739/2310-1210.2015.1.38736

Keywords:

Stroke, Tumor Necrosis Factors, Prognosis

Abstract

Aim. The results of investigation of 78 patients in acute period of  brain ischemic aterotrombotic stroke are given in the article.

Methods and results. It was revealed that development of brain ischemic aterotrombotic stroke is accompanied with elevation of TNF-α (Δ%=419,8; p<0,05) in the first day of disease. Serum concentration of TNF-α during first 24 hours of brain ischemic aterotrombotic stroke onset correlates with summary ball on NIH scale in the onset of stroke (R=0,67; p<0,05), modified Rankin’s scale ball on 21st day (R=0,69; p<0,05) and course of the disease.

Conclusion. Mathematic model of peracute period of brain ischemic aterotrombotic stroke course prognosis was designed, which was based on  TNF-α serum levels detection on the first day of stroke onset. It is characterized with accuracy of 87.2%.

References

Fraunberger, P., Wang, Y., Blessing, F., et al. (2005). Atherogenesis: Interplay between Cholesterol, Inflammation and Coagulation. Herz., 30(8), 723–732. doi: 10.1007/s00059-005-2658-9.

Barone, F. C. & Parsons, A. A. (2000). Therapeutis potential of anti-inflammatory drugs in focal stroke. Expert Opin. Investig. DrugsVol, 10, 2281–2306. doi: 10.1517/13543784.9.10.2281.

Pettigrew, L. MarkKindy, S., Scheff, S., et al. (2008). Focal cerebral ischemia in the TNF-α-transgenic rat. J. Neuroinflammation, 5, 47–51. doi:10.1186/1742-2094-5-47.

Castellanos, M., Castillo, J., Garcia, M. M., et al. (2002). Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target. StrokeVol., 33(4), 982–987.

Gilhus, N. E., Barnes, M. R., & Brainin, M. (2011). European Handbook of Neurological Management.

Libby, P., & Galis, Z. S. (1995). Cytokines regulate genes involved in atherogenesis. Ann. N.Y. Acad. SciVol., 748, 158–168.

Mukherjee, D., & Patil, C. G. (2011). Epidemiology and the global burden of stroke. World Neurosurg, 76(6), 85–90. doi: 10.1016/j.wneu.2011.07.023.

Jonsson, H., Johnsson, P., Ailing, C., et al. (1999). S-100b after coronary artery bypass surgery: Release pattern, source of contamination, and relation to neuropsychological outcome. Ann. Thorac. SurgVol., 68, 2202–2208. doi: 10.1016/S0003-4975(99)00851-6.

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How to Cite

1.
Neryanova YN. Prognosis of peracute period of brain ischemic aterotrombotic stroke course on the ground of TNF-α serum levels detection in the first day of disease. Zaporozhye Medical Journal [Internet]. 2015Feb.9 [cited 2024Nov.23];17(1). Available from: http://zmj.zsmu.edu.ua/article/view/38736

Issue

No. 1 (2015): Zaporozhye Medical Journal

Section

Original research

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