DOI: https://doi.org/10.14739/2310-1210.2015.1.39876

Патогенетическая взаимосвязь ишемической болезни сердца и остеопенического синдрома

N. S. Mykhailovskaya, I. O. Shevchenko, O. А. Zelenina

Аннотация


Актуальность проблемы ишемической болезни сердца, коморбидной с остеопорозом, обусловлена увеличением распространенности, отсутствием своевременной диагностики, профилактики, тяжелыми осложнениями и значительным влиянием на качество жизни пациентов. С целью представить и обобщить современный взгляд на патогенетическую связь ишемической болезни сердца и остеопенического синдрома провели обзор специализированной литературы. Установили, что ишемическая болезнь сердца и остеопороз имеют общие факторы риска (гиподинамія, курение, злоупотребление алкоголем, масса тела, нерациональное питание и т.д.) и механизмы прогрессирования с вовлечением каскада провоспалительных цитокинов, остеопротегерина, эндотелиальной дисфункции, эстрогенов, дефицита кальция, ренин-ангиотензин-альдостероновой и симпатической нервной системы.


Ключевые слова


ишемическая болезнь сердца; остеопороз; остеопенический синдром; кальцификация атеромы; остеопротегерин

Полный текст:

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Литература


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