Pathogenetic relationship between coronary heart disease and osteopenic syndrome

Authors

  • N. S. Mykhailovskaya
  • I. O. Shevchenko
  • O. А. Zelenina

DOI:

https://doi.org/10.14739/2310-1210.2015.1.39876

Keywords:

Myocardial Ischemia, Osteoporosis, Osteopenia, Vascular Calcification, Osteoprotegerin

Abstract

The importance of the comorbidity problem of coronary heart disease and osteoporosis is caused by the rising prevalence, lack of early detection, prevention, severe complications and significant impact on the quality of life of the patients.

Aim. In order to compile and submit a current point of view on the pathogenetic relationship between the coronary heart disease and the osteopenic syndrome we reviewed specialized literature.

Conclusion. We established that coronary heart disease and osteoporosis have common mechanisms of progression involving a cascade of proinflammatory cytokines, osteoprotegerin, endothelial dysfunction, estrogen, calcium deficiency, the renin-angiotensin-aldosterone and sympathetic nervous system.

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How to Cite

1.
Mykhailovskaya NS, Shevchenko IO, Zelenina OА. Pathogenetic relationship between coronary heart disease and osteopenic syndrome. Zaporozhye Medical Journal [Internet]. 2015Feb.9 [cited 2024Oct.6];17(1). Available from: http://zmj.zsmu.edu.ua/article/view/39876