Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction
DOI:
https://doi.org/10.14739/2310-1210.2015.2.42005Keywords:
Heart Failure, Biomarkers, FibrosisAbstract
Aim. To identify features, relationships between parameters of the extracellular matrix and renal function in 110 patients with ischemic chronic heart failure the activity of collagen metabolism markers (MMP-9, TIMP-1, PICP), cystatin C, structural and functional parameters of the heart were studied using ELISA, echocardiography.
Results. It was established that imbalance in the system MMP/TIMP in ischemic heart failure with preserved left ventricular ejection fraction leads to disruption of the extracellular matrix structural functional sufficiency, increases functional failure and is associated with impaired renal function.
Conclusion. Correlation analysis showed significant relationships between MMP/TIMP and GFR, cystatin C, indicating that the significant role of extracellular matrix imbalance in the development of renal dysfunction in patients with ischemic chronic heart failure.
References
Pellicori, P., & Cleland, J. (2014). Heart failure with preserved ejection fraction. Clinical Medicine, 14(6), s22-s28. doi:10.7861/clinmedicine.14-6-s22.
Andersen, M., & Borlaug, B. (2014). Heart Failure with Preserved Ejection Fraction: Current Understandings and Challenges. Curr Cardiol Rep, 16(7). doi:10.1007/s11886-014-0501-8
Bradham, W. (2002). Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective. Cardiovascular Research, 53(4), 822–830. doi:10.1016/s0008-6363(01)00503-x.
Sivasubramanian, N., Coker, M., Kurrelmeyer, K., MacLellan, W., DeMayo, F., Spinale, F., & Mann, D. (2001). Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor. Circulation, 104(7), 826–831. doi:10.1161/hc3401.093154.
Hamer, R. (2006). The burden of chronic kidney disease. BMJ, 332(7541), 563–564. doi:10.1136/bmj.332.7541.563.
Yang, D., Ma, S., Tan, Y., Chen, Y., Li, D., & Tang, B. et al. (2010). Imbalance of Matrix Metalloproteinases/Tissue Inhibitor of Metalloproteinase-1 and Loss of Fibronectin Expression in Patients with Congestive Heart Failure. Cardiology, 116(2), 133–141. doi:10.1159/000317245.
Voronkov, L. G., Amosova, K. M., Bahrii, A. E., Dziak, H. V., Diadyk, O. I., Zharinov, O. Y., et al. (2012) Rekomendatsii z diahnostyky ta likuvannia khronichnoi sertsevoi nedostatnosti [Guidelines for the diagnosis and treatment of chronic heart failure]. Sertseva nedostatnist, 3, 60–96 [in Ukrainian].
Pauschinger, M., Chandrasekharan, K., Li, J., Poller, W., Noutsias, M., & Tschope, C., et al. (2002). Inflammation and extracellular matrix protein metabolism: two sides of myocardial remodelling. Eur Heart J, 4(1), 49–53.
Sundstrom, J. (2004). Relations of Plasma Matrix Metalloproteinase-9 to Clinical Cardiovascular Risk Factors and Echocardiographic Left Ventricular Measures: The Framingham Heart Study. Circulation, 109(23), 2850–2856. doi:10.1161/01.cir.0000129318.79570.84.
Radauceanu, A., Ducki, C., Virion, J., Rossignol, P., Mallat, Z., & McMurray, J., et al. (2008). Extracellular Matrix Turnover and Inflammatory Markers Independently Predict Functional Status and Outcome in Chronic Heart Failure. Journal Of Cardiac Failure, 14(6), 467–474. doi:10.1016/j.cardfail.2008.02.014.
Caron, A., Desrosiers, R., & Béliveau, R. (2005). Ischemia injury alters endothelial cell properties of kidney cortex: Stimulation of MMP-9. Experimental Cell Research, 310(1), 105–116. doi:10.1016/j.yexcr.2005.07.004.
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