Gender and age peculiarities of content changes of protein C, von Willebrand factor, vascular cell adhesion molecules sVCAM-1 in patients with acute left ventricle Q-wave myocardial infarction

Authors

DOI:

https://doi.org/10.14739/2310-1210.2015.2.42007

Keywords:

Protein C, von Willebrand Factor, Vascular Cell Adhesion Molecules sVCAM-1

Abstract

Markers of hemostasis have an influence on the state of postinfarction remodeling processes.

Aim. In order to study the gender and age peculiarities, to determine the predictive value of the protein C, von Willebrand factor and vascular cell adhesion molecules sVCAM-1 concentration, we examined 76 patients with acute Q-wave myocardial infarction.

Methods and results. On the 1st day of the disease, higher concentrations of protein C were detected in young women, vascular cell adhesion molecules sVCAM-1 - in men of any age. On the 10th day of the disease, both in men and women increase in the content of protein C, reducing the concentration of von Willebrand factor and vascular cell adhesion molecules sVCAM-1 were detected.

Conclusion. Protein C has the highest prognostic potential in relation to the formation of heart aneurysm after Q-wave myocardial infarction in women of young age, and von Willebrand factor and vascular cell adhesion molecules sVCAM-1 - in older men.

References

Akimtseva, E. A., Kotovschikova, E. F. (2012) Markery e'ndotelial'noj disfunkcii kak prediktory razvitiya retrombozov koronarnykh stentov [Markers of endothelial dysfunction as development predictor coronary stent rethrombosis]. Fundamental'nye issledovaniya, 8, 271–273. [in Russian].

Gusev, D. E., Pal'tseva, E. M., Potievskiĭ, B. G., Rodina, A. V., Nikiforova, E. V., Ponomar, E. G., et al. (2009) Molekuly adgezii sVCAM-1 i sICAM-1 pri razlichnykh formakh ishemicheskoj bolezni serdca [Adhesion molecules sVCAM-1 and sICAM-1 at different forms of coronary heart disease]. Kardiologiya i serdechno-sosudistaya khirurgiya, 2, 11–14. [in Russian].

Kyselev, S. M. (2014) Osoblyvosti zmin hemostazu pid vplyvom riznykh rezhymiv antyagregantnoi terapii khvoryh na Q-infarkt miokarda [Peculiarities of hemostasis changes under the influence of different regimens of antiplatelet therapy in patients with Q-wave myocardial infarction]. Patologiia, 3(32), 34–38. [in Ukrainian].

Simonyan, T. V. (2008) Osobennosti sistemy proteina C u prakticheski zdorovykh lic razlichnykh vozrastnykh grupp [Peculiarities of protein C system in almost healthy persons of different age groups]. Fundamentalnaya nauka i klinicheskaya medicina. Proceedings of the Scientific Conference, (pp. 143–145). Saint Petersburg [in Russian].

Kovalenko, V. M. & Kornatskii, V. M. (Eds) (2014) Khvoroby systemy krovoobihu yak medyko-sotsialna i suspilno-politychna problema. [Cardiovascular system diseases as medicine-social and socio-political problem.]. Kyiv [in Ukrainian].

Сhernysh, O. A., Gubkin, S. V., & Oganova, E. G. (2010) Ocenka riska vozniknoveniya oslozhnenij i prognoz u bol'nykh krupnoochagovym infarktom miokarda v ostrom periode i u pacientov s IBS do i posle aortokoronarnogo shuntirovaniya [Assessment of complication risk and prognosis in patients with Q-wave myocardial infarction in acute period and in patients with ischemic heart disease before and after aortocoronary bypass surgery]. Voennaya medicina, 2, 112–117. [in Belarus].

Shevchuk, S. V., Hornytska, O. V., Chernyshenko, T. M., Krasnobryzha, Ye. M., Korolova, D. S., Chernyshenko, V. O., & Platonova, T. M. (2010) Kompleksna diahnostyka trombofilii za systemnoho chervonho vovchaka [Complex diagnostics of thrombophilia in patients with systemic lupus erythematous]. Laboratorna diahnostyka, 1, 3–8. [in Ukrainian].

Shushlyapin, O. I., Kononenko, O. H., & Manik, I. M. (2006) Faktor Willebranda i ego rol' v disfunkcii e'ndoteliya pri ishemicheskoj bolezni serdca: diagnostika, kriterii prognoza i perspektivnye podkhody k terapii [Von Willebrand factor and their role in endothelial dysfunction in ischemic heart disease: diagnostics, prognostic criterions and perspective therapeutic ways]. Ukrainskii kardiolohichnyi zhurnal, 3, 126–131. [in Ukrainian].

Kolchanova, S. G., Grinko, A. A., Zinovieva, Y. A., Sokolov, S. Y, Ustyusganin, S. S, Shur, M. L, & Blyakhman, F. A. (2004) The regional elastic properties analysis of myocardium based on echocardiographic 3D reconstruction of the left ventricle. J. Ultrasound in medicine and biology, 30(3), 311–320.

How to Cite

1.
Kyselov SM. Gender and age peculiarities of content changes of protein C, von Willebrand factor, vascular cell adhesion molecules sVCAM-1 in patients with acute left ventricle Q-wave myocardial infarction. Zaporozhye Medical Journal [Internet]. 2015Apr.27 [cited 2024Dec.24];17(2). Available from: http://zmj.zsmu.edu.ua/article/view/42007

Issue

Section

Original research