Yacton and mexicor influence on prooxidant-antioxidant homeostasis and protein synthesis in the myocardium of rats in conditions of doxorubicin cardiomyopathy

Authors

  • E. A. Raketskaya
  • I. S. Chekman
  • N. A. Gorchakova

DOI:

https://doi.org/10.14739/2310-1210.2015.2.42016

Keywords:

Yacton, Mexicor, Homeostasis, Proteins

Abstract

Doxorubicin, which is included in the scheme of cancer treatment, possesses cardiotoxicity that requires effective cardioprotectors searching.

Aim. The aim of the study was to compare the influence of yacton and mexicor on the antioxidant system, oxidative modification of proteins, protein synthesis in the myocardium of rats in conditions of doxorubicin cardiomyopathy.

Methods and results. The content of prooxidant-antioxidant homeostasis indicators - SOD, GPR, GR, AFG, KFG and proteinsynthesis – the protein content in the cytoplasma and mitochondria and protective effect of derivatives of succinic acid (yacton, mexicor) were studied in the myocardium of rats in the conditions doxorubicin cardiomyopathy with wellknown methods.

Conclusion. It is stated that yakton similar to mexicor has protective influence on the prooxidant-antioxidant homeostasis, protein synthesis in the rats myocardium in conditions of doxorubicin cardiomyopathy.

 

References

Fyliak, O. S., Fyliak, Ye. S., & Toika, R. S. (2005) Vplyv doksorubitsynu na fosforyliuvannia bilka SMAD3 zadiianoho u syhnalnomu shliakhu transformuiuchoho faktora rostu S3 u klitynakh linii A549 kartsynomy leheniv liudyny [Effect of doxorubicin on phosphorylation of protein SMAD3 which is involved into signaling pathway of transforming growth factor β in human lung carcinoma A549 cells]. Medychna khimiia, 7(1), 52–62. [in Ukrainian].

Hrelia, S., Fiorentini, D., Maraldi, T., Angeloni, C., Bordoni, A., Biagi, P. L., & Hakim, G. (2002) Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes. Biochim. Biophys. Acta, 1567(1–2), 150–156.

Kovalenko, V. N., Kalinkina, N. V., & Vatutin, N. T. (2002) Povrezhdenyia serdca citostatikami [Heart damage by cytostatics]. Doneck. [in Ukrainian].

Trofimova, T. S., Chekman, I. S., Horchakova, N. O., & Avramenko, M. O. (2004) Kardiotoksychnist doksorubitsynu ta shliakhy korektsii tiotryazolinom [Doxorubicin cardiotoxicity and path ways of its correction by thiotriazolin]. Zaporozhskij medicinskij zhurnal, 5, 153–155. [in Ukrainian].

Chekman, I. S., Horchakova, N. O., Nahorna, O. O., & Nebesna, T. Yu. (2008) Nikotynamid [Nicotinamide]. Kyiv: Polihrafplius. [in Ukrainian].

Yakovleva, I. Yu., & Belenichev, I. F. (2009) Neiroprotektyvna diia yaktonu [Neuroprotective action of yakton]. Visnyk problem biolohii i medytsyny, 1, 145–150. [in Ukrainian].

Maksimchuk, E. A., Gorchakova, N. A., & Chekman, І. S. (2009) Mekhanizmy razvitiya kardiotoksichnosti doksorubicina i puti preduprezhdeniia [Mechanisms of doxorubicin cardiotoxicity and ways of prevention]. Naukovyi visnyk Natsionalnoho medychnoho universytetu imeni O.O. Bohomoltsia, 4, 275–279. [in Ukrainian].

Korokin, M. V., Pokrovskij, M. V., Konovalova, E. A., Savvin, V. A., Honcharov, N. F., Denisiuk, T. A., et al. (2012) Vozmozhnosti farmakologicheskoj korrekcii endotelial`noj disfunkcii y koronarnogo krovotokа s pomoshchyu mildronata i meksikora [Possible pharmacological correction of endothelial dysfunction and coronary blood flow with mildronate and mexicor]. Nauсhnye vedomosti Belgorodskogo gosudarstvennogo universiteta, 4(123), 189–197. [in Russian].

Chekman, I. S., Gubskij, Yu. I., Hromov, L. A., Belenichev, I. F. (2010) Doklinicheskoe izuchenie specificheskoj aktivnosti potencial`nykh nejroprotektivnykh preparato [Preclinical study of the potential neuroprotective drugs specific activity]. Kiev. [in Ukrainian].

Chekman, I. S., Gorchakov, N. A., Francuzova, S. B., & Nagornaya, E. A. (2009) Metabolicheskie i metabolitotropnye preparaty v sisteme kardio- i orghanoprotekcii [Metabolic and metabolitotropic drugs in the system of cardio and organoprotection]. Kiev: Poligrafplyus. [in Ukrainian].

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How to Cite

1.
Raketskaya EA, Chekman IS, Gorchakova NA. Yacton and mexicor influence on prooxidant-antioxidant homeostasis and protein synthesis in the myocardium of rats in conditions of doxorubicin cardiomyopathy. Zaporozhye Medical Journal [Internet]. 2015Apr.27 [cited 2024Dec.24];17(2). Available from: http://zmj.zsmu.edu.ua/article/view/42016

Issue

No. 2 (2015): Zaporozhye medical journal

Section

Original research

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