Comparative assessment of the effectiveness of modern neuroprotectors in conditions of experimental chronic cerebral ischemia

Authors

  • A. V. Demchenko
  • І. F. Belenichev

DOI:

https://doi.org/10.14739/2310-1210.2015.2.42042

Keywords:

Brain Ischemia, Cytidine-5'-diphosphate-choline, Cortexin, Tiocetam

Abstract

Modern pharmacological influence on the pathological changes in cerebral ischemia is actual task of the modern neurology.

Aim. To make a comparative assessment of the effectiveness of modern neuroprotectors in conditions of experimental chronic cerebral ischemia.

Methods and results. Experimental study of the neuroprotective effects of the citicoline, cortexin and tiocetam on the cognitive functions on the model of the chronic cerebral ischemia was conducted on 75 white rats. Biochemical, immunoassay, pharmacological, statistical methods were used.

Conclusion. Obtained results showed citicoline, cortexin and tiocetam ability to positively influence on the molecular-biochemical changes in the brain cortex with ischemia. This resulted in the glutathione-dependent enzymes activity increase, recover of the thiol-disulfide system balance, nitrotyrosine concentration decrease, improvement of the cognitive function in the experimental animals.

References

Barkhatov, D. Yu., Glotova, N. A., Konovalov, R. N., Fedin, P. A., Gur'ev, M. N., & Tanashyan M. M. (2011). E'ffektivnost' nejroprotekcii u bol'nykh s khronicheskimi cerebrovaskulyarnymi zabolevaniyami [Efficiency of neuroprotection among patients with chronical cerebrovascular diseases]. Mіzhnarodnyi nevrolohіchnyi zhurnal, 7(45), 37–42. [in Ukrainian].

Byelenіchev, I. F., Chernij, V. I., & Kolesnik, Yu. M. (2009). Racionalnaya nejroprotekciya [Rational neuroprotection]. Doneck: Zaslavskij. [in Ukrainian].

Bobrova, V. I., Kolesnik, Yu. M., Belenichev, I. F., & Demchenko, A. V. (2010). Tiocetam v kompleksnoj terapii khronicheskoj ishemii mozga [Tiocetam in complex therapy of chronic brain ischemia]. Zaporozhskij medicinskij zhurnal, 12(5), 130–135. [in Ukrainian].

Buresh, Ya., Bureshova, O., & H'yuston, D. (1991). Metodiki i osnovnye e`ksperimenty po izucheniyu mozga i povedeniya [Methods and principle experiments of studing brain and behaviour]. Moscow: Vysshaya shkola. [in Russian].

Madzhidova, Yo. N., & Usmanova, D. D. (2012). E`ffektivnost' korteksina v korrekcii kognitivnykh rasstrojstv u pacientov s khronicheskoj ishemiej mozga [Efficiency of cortexin in cognitive diseases correction among patients with chronical cerebral ischemia]. Mіzhnarodnyj nevrolohіchnyj zhurnal, 4(50), 48–50. [in Ukrainian].

Chekman, I. S., Gubskij, Yu. I., & Belenichev, I. F. (2010). Doklinicheskoe izuchenie specificheskoj aktivnosti potencial'nykh nejroprotektivnykh preparatov [Pre-clinical studying of potential neuroprotecor medicines specific activity]. Кyiv: GFC MZ Ukrainy. [in Ukrainian].

Adibhafla, R. M., & Hatcher, J. F. (2005). Citidine 5-diphosphocholine (CDP-Choline) insfrokeandofher CNS disorders. Neurochemical Research, 30, 15–23.

Dhar-Mascareño, M., Carcamo, J. M., & Golde, D. W. (2005). Hypoxia-reoxygenationinduced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C. Free Radic Biol Med, 38, 1311–1322.

Liu, H., Wang, H., Shenvi, S., Hagen, T. M., & Liu, R. M. (2004). Glutathione metabolism during aging and in Alzheimer disease. Ann. N. Y. Acad. Ski, 1019, 346–349. doi: 10.1196/annals.1297.059.

Lowry, O. H., Rosebrough, N. J., Farr, A. L., & Randall R.J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265–275.

How to Cite

1.
Demchenko AV, Belenichev ІF. Comparative assessment of the effectiveness of modern neuroprotectors in conditions of experimental chronic cerebral ischemia. Zaporozhye Medical Journal [Internet]. 2015Apr.27 [cited 2024Oct.16];17(2). Available from: http://zmj.zsmu.edu.ua/article/view/42042

Issue

Section

Original research