The level of plasma homocysteine in patients with non-alcoholic fatty liver disease in combination with type 2 diabetes


  • V. F. Orlovskiy
  • N. G. Kuchma
  • A. V. Orlovskiy
  • N. O. Murenets



Non-Alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, Homocysteine


Non-alcoholic fatty liver disease (NAFLD) is one of the major causes of chronic diseases of the hepatobiliary zone.

Aim. In order to explore new pathogenetic factors of NAFLD examined the level of plasma homocysteine in 110 patients.

Methods and results. Patients were divided into two groups - the isolated NAFLD and in combination with Diabetes mellitus type 2. Found a significant increase in homocysteine level in all patients with NAFLD compared with the control group. High homocysteine concentration was in patients with comorbidity. There was positive correlation between levels of homocysteine and lipid components and cytolytic syndrome in all patients.

Conclusion. The data obtained allow us to consider homocysteine as one of the factors in the pathological changes development in the liver.


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How to Cite

Orlovskiy VF, Kuchma NG, Orlovskiy AV, Murenets NO. The level of plasma homocysteine in patients with non-alcoholic fatty liver disease in combination with type 2 diabetes. Zaporozhye Medical Journal [Internet]. 2015Jun.15 [cited 2024Jun.18];17(3). Available from:



Original research