Application of venotonics for correction of sinusoidal dysfunction in patients with cirrhosis
DOI:
https://doi.org/10.14739/2310-1210.2015.3.44490Keywords:
Cirrhosis, Portal Hypertension, Endothelium, Dysfunction, Vasodilatator AgentsAbstract
Elaboration of the uniform tactical installations concerning questions of diagnostics, rational therapy of patients with sinusoidal dysfunction at cirrhosis and its complications is actual.
Aim. For the purpose of assessment of a role of sinusoidal dysfunction at complications of cirrhosis results of 35 patients’ treatment with sinusoidal dysfunction correction were studied.
Methods and results. As basis venotonics were used in therapy. The clinical condition of patients, data of ultrasonic dopplerography characterizing the blood flow in vv. porte and lienalis were estimated. It was established that application of venotonics improves portal perfusion and portal vein diameter decrease and linear speed of a blood flow increase.
Conclusion. It testifies to the importance of correction of sinusoidal dysfunction and prevention of complications development in patients with cirrhosis.
References
Bulatova, I. A. (2009) Funkcional'noe sostoyanie e`ndoteliya i ego diagnosticheskaya znachimost' pri ocenke tyazhesti khronicheskikh diffuznykh zabolevanij pecheni (Dis… kand. med. nauk). [A functional condition an endoteliya and its diagnostic importance at an assessment of weight of chronic diffuzny diseases of a liver]. Dr. med. sci. diss.] Yekaterinburg. [in Russian].
Garbuzenko, D. V. (2010) Patofiziologicheskie mekhanizmy i novye napravleniya terapii portal'noj gipertenzii pri cirroze pecheni [Pathophysiological mechanisms and new directions of therapy of portal hypertension at liver cirrhosis]. Klinicheskie perspektivy gastroe'nterologii, gepatologii, 6, 11–20. [in Russian].
Mirodzhov, G. K., Avezov, S. A., Giyazov, M. M., & Mirodzhova, S. G. (2011) Primenenie diosmina pri vnutripechenochnoj portal'noj gipertenzii [Application of diosmini at intra hepatic portal hypertensia]. Rossijskij zhurnal gastroe`nterologii, gepatologii, koloproktologii, 1(21), 40–43. [in Russian].
Harchenko, N. V., Anokhin, G. A., & Harchenko, V. V. (2011) Korektsiia porushen funktsionalnoho stanu pechinky, vmistu lipidiv, homotsysteinu krovi, endotelialnoi funktsii ta enerhetychnoho obminu u khvorykh na nealkoholnyi steatohepatyt u poiednanni z hipertonichnoiu khvoroboiu [Correction of violations of a functional condition of a liver, the maintenance of lipids, гомоцистеина blood, endotelialny function and a power exchange at patients not alcoholic steatogepatity in a combination to a hypertensive illness]. Suchasna hastroenterolohiia, 1(57), 27–32. [in Ukrainian].
Savel`ev, V. S., & Petukhov, V.A. (2008) E`ndotelial'naya disfunkciya v khirurgii [Endotelialny dysfunction in surgery]. Сonsilium-medicum, Hirurgiya, 1, 2–5. [in Russian].
Bellot, P., Francés, R., & Such, J. (2013) Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications. Liver International, 33(1), 31–39. doi: 10.1111/liv.12021.
Eisinger, K., Krautbauer, S., Wiest, R., Karrasch, T., Hader, Y., Scherer, M. N., et al. (2013) Portal vein omentin is increased in patients with liver cirrhosis but is not associated with complications of portal hypertension. European Journal of Clinical Investigation, 43(9), 926–932. doi: 10.1111/eci.12122
Garcia-Pagan, J. C., Gracia-Sancho, & J., Bosch, J. (2012) Functional aspects on the pathophysiology of portal hypertension in cirrhosis. J Hepatology, 57(2), 458–461. doi: 10.1016/j.jhep.2012.03.007.
Iwakiri, Y., Shah, V., & Rockey, D. C. (2014) Vascular pathobiology in chronic liver disease and cirrhosis – Current status and future directions. J Hepatology, 61(4), 912–924. doi: 10.1016/j.jhep.2014.05.047.
Mallat, A., Teixeira-Clerc, F., & Lotersztajn, S. (2013) Cannabinoid signaling and liver therapeutics. J Hepatology, 59(4), Р. 889–890. doi: 10.1016/j.jhep.2013.03.032.
Mehta, G., & Mookerjee, R.P. (2014) Breaking Bad – the two sides of gut microbiota in portal hypertension. Liver International, 34(9), 1295–1297. doi: 10.1111/liv.12598.
Rautou, P.-E. (2012) Endothelial progenitor cells in cirrhosis: The more, the merrier? Journal of Hepatology, 57(6), 1163–1165. doi: 10.1016/j.jhep.2012.09.001.
Sakamoto, M., Nakamura, T., Torimura, T., Iwamoto, H., Masuda, H., Koga, H., et al. (2013) Transplantation of endothelial progenitor cells ameliorates vascular dysfunction and portal hypertension in carbon tetrachloride-induced rat liver cirrhotic model. J Gastroenterology and Hepatology, 28(1), 168–178. doi: 10.1111/j.1440-1746.2012.07238.x.
Silva, G. (2013) New serum markers for predicting esophageal varices: Is it a reality? J Gastroenterology and Hepatology, 28(1), P. 4–5. doi: 10.1111/jgh.12025.
Thabut, D., & Shah, V. (2010) Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension? J Hepatology, 53(5), 976–980. doi: 10.1016/j.jhep.2010.07.004.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
