Blood supply of the telencephalon radiate crown of the rat in norm and under the long-term opioid use
DOI:
https://doi.org/10.14739/2310-1210.2015.3.44493Keywords:
Telencephalon, Blood Vessels, Rats, NalbuphineAbstract
Aim. The objective of this study was to establish peculiarities of the channels of blood supply of the telencephalon radiate crown of the rat in norm and in the dynamics in 6 weeks long injection of nalbuphine.
Methods and results. The research work was carried out on 24 mature white male rats aged 3.0 – 4.5 months weighing 160-270 g. The method applied in the study was injection of bloodstream along with morphometric and statistical methods. Morphological and morphometric analysis of angioarchitecture of telencephalon radiate crown allowed to evaluate the degree of its vascularization in case of a long-term effect of nalbuphine.
Conclusion. Results showed that there is a clearly observed connection between the depth of structural transformations of the parts of hemomicrocirculatory bloodstream of the rat’s radiate crown under the influence of opioid and the morphometric indices. The obtained results can serve as the morphologic basis for further scientific research in neurology.
References
Lelevich, S. V., Lelevich, V. V., & Doroshenko, E. M. (2009). Harakteristika nejromediatornykh sistem nekotorykh struktur golovnogo mozga krys pri morfinovoj abstinencii [Characteristics of some neurotransmitter systems of the brain structures of rats with morphine withdrawal]. Voprosy narkologii, 3, 70–77. [in Russian].
Litvincev, B. S. (2003). Strukturno-funkcional'nye izmeneniya nervnoj sistemy pri khronicheskom otravlenii opioidami (Avtoref. dis…kand. med. nauk). [Structural and functional changes in the nervous system in chronic opioid poisoning]. (Extended abstract of candidate’s thesis). Moscow. [in Russian].
Mamina, O. O. (2006). Khimiko-toksykolohichne doslidzhennia narkotychnykh rechovyn v orhanakh otruienykh shchuriv [Chemical and toxicological studies of drugs in the bodies of poisoned rats]. Zaporozhskij medicinskij zhurnal, 6, 140–142. [in Ukrainian].
Ovcharenko, M. O. (2013). Opioidna zalezhnist: kliniko-patohenetychni, epidemiolohichni, patopsykholohichni aspekty, metody likuvannia i profilaktyky (Avtoref. dis… dokt. med. nauk) [Opioid dependence: clinical and pathogenetic, epidemiological, pathopsychological aspects, treatment and prevention. Dr. med. sci. diss.]. Kharkiv. [in Ukrainian].
Lvivskyi natsionalnyi medychnyi universytet imeni Danyla Halytskoho (patentee) (2012) Patent Ukrainy №76564 U Ukraina, MPK A 61 K 31/00 Sposib modeliuvannia fizychnoi opioidnoi zalezhnosti u shchuriv [U Ukraina, MPK А 61 K 31/00 Method of simulation of the physical opioid dependence in rats]. Biuleten, 1 [in Ukrainian].
Fisenko, V. P. (2001). Nejrokhimicheskie zakonomernosti dejstviya opioidnykh anal'getikov na koru golovnogo mozga [Neurochemical patterns of action of opioids on the cerebral cortex]. Eksperimental`naya biologiya i medicina, 32(7), 4–12. [in Russian].
Shapovalov, V. V. (2011). Sudova farmatsiia v derzhavnii systemi zakhodiv uzahalnennia prychyn i umov poshyrennia narkozlochynnosti ta narkomanii (na zasadakh kryminalistyky) [Forensic pharmacy in the state system measures summarizing the causes and conditions of distribution and drug addiction (based on criminology)]. Yurydychnui zhurnal, 6, 41–45. [in Ukrainian].
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