Morphological features of the structure of the cerebellar cortex of rats in the norm and under prolonged exposure to the opioid
DOI:
https://doi.org/10.14739/2310-1210.2015.3.44505Keywords:
Cerebellar Cortex, Opioid, Experimentation Animal, Nalbuphine, NarcoticsAbstract
In recent decades the issue of drug addiction has appeared to be not only a social, but medical problem.
Aim. To establish peculiarities of the microstructure of the rat’s cerebellar cortex in the norm and to investigate changes in the structural organization of cerebellar cortex determined by injection of the opioid, particularly nalbuphine, in the experiment.
Methods and results. These investigations were carried out on 26 mature white male rats aged 3.0–4.5 months and body weight 160–270 g. The research material was presented by histological specimens of the rats’ cerebellar cortex. Sections of the cerebellar cortex for histological examination were stained with hematoxylin and eosin. The first signs of disorders in the structure of the rat’s cerebellar cortex have been detected already after 2 weeks of the experimental injection of nalbuphine. Destructive changes in cerebellar cortex cells and in the haemomicrocirculatory bloodstream increased gradually during 6 weeks of the experiment.
Conclusion. Thus, nalbuphine injection during 6 weeks of the experiment leads to disorganization of microstructure and angioarchitecture of cerebellar cortex.
References
Golubev, V. L., & Danilov, A. B. (2010). Psikhologicheskie ustanovki pacienta i perezhivanie boli [Attitudes and experience of the patient's pain], Rossijskij medicinskij zhurnal, 18(31), 2–5. [in Russian].
Viievskyi, A. M., Zhdanova, M. P., Sydiak, S. V., et al. (2011). Zriz narkotychnoi sytuatsii v Ukraini (dani 2010 roku) [Cut drug situation in Ukraine (data 2010)]. [in Ukrainian].
Viievskyi, A. M., Zhdanova, M. P., Sydiak, S. V., Beznohykh, V. S., Hryshchenko, A. I., & Lepekha, K. I. (2012). Zriz narkotychnoi sytuatsii v Ukraini (dani za 2011 r.) [Cut drug situation in Ukraine (data 2011)]. [in Ukrainian].
Kryzhanovskij, G. N (2003). Vazhnoe sobytie v otechestvennoj medicine [An important event in the domestic medicine]. Rossijskij zhurnal boli, 1, 4–5. [in Russian].
Onysko, I. O., & Onysko, R. M. (2013) Zminy na svitlooptychnomu rivni u strukturakh yazyka, yaki sprovokovani vplyvom malykh doz opioidu protiahom 14-ty i 28-my dib [Changes of the tongue in the microstructural level under the influence of small doses of opioids during 14 and 28 days] Eksperymentalna ta klinichna fiziolohiia i biokhimiia, 3, 20–25. [in Ukrainian].
Pavlenko, S. S., Denisov, V. N., & Fomin, G. I. (2002). Organizaciya medicinskoj pomoschi bol'nym s khronicheskimi bolevymi sindromami [Organization of medical care for patients with chronic pain syndromes]. Novosibirsk: Novosibirskij poligrafkombinat [in Russian].
Pankova, T. M., Sorokina, N. S., Starostina, M. V. (2004). Vyyavlenie sajtov svyazyvaniya antitel k morfinu v golovnom mozge krys [Identification of sites for specific binding of antibodies to morphine in rat`s brain]. Sibirskij nauchnyj medicinskij zhurnal, 24(3), 156–159. [in Russian].
Onysko, R. M., Paltov, Ye. V., Fіk, V. B., Vіlkhova, І. V., Kryvko, Yu. Ya., Yakymіv, N. Ya., & Fіtkalo, O. S. (patentee) (2013) Patent №76564 Sposib modeliuvannia fizychnoi opioidnoi zalezhnosti u shchuriv [Patent №76564 Method simulation of physical opioid dependence in rats]. Biuleten, 1 [in Ukrainian].
Pidvalna, U. Ye. (2014). Strukturni osoblyvosti sudynnoi obolonky ochnoho yabluka za umov dovhotryvaloho opioidnoho vplyvu v eksperymenti [Structural features of the choroid under the opioid long term influence in the experiment]. Visnyk Ukrainskoi medychnoi stomatolohichnoi akademii, 4(48), 209–212. [in Ukrainian].
Popyk, P. M (2014) Morfolohichni zminy sudyn pidshlunkovoi zalozy pry perytoniti, sprychynenomu vvedenniam nalbufinu v eksperymenti [The morphological changes of the pancreatic gland vessels in case of peritonitis caused by nalbuphine in the experiment]. Visnyk morfolohii, 1, 170–172. [in Ukrainian].
Fomina, K. A. (2012) Anatomo-morfofunkcional'naya kharakteristika golovnogo mozga krys razlichnogo vozrasta posle ingalyacionnogo vozdejstviya e`pihlorgidrina [The anatomic and morphofunctional characteristic of the brain of different aged rats after ingalation exposure of epichlorhydrinum]. Ukrainskyi zhurnal klinichnoi ta laboratornoi medytsyny, 7(2), 153–156. [in Ukrainian].
Yakumiv, N. Ya., & Kryvko, Yu. Ya. (2013) Mikrostrukturna kharakterystyka raiduzhno-rohivkovoho kuta ochnoho yabluka shchuriv pry opioidnomu vplyvi [The microstructural characteristics of irido-corneal angle of eye of rats under the influence of opioids]. Svit medytsyny ta biolohii, 4, 117–120. [in Ukrainian].
Yakhno, N. N., Barinov, A. V., & Podchufarova, E. V. (2008). Nevropaticheskaya i skeletno-myshechnaya bol'. Sovremennye podkhody k diagnostike i lecheniyu [Neuropathic and skeletal-muscle pain. Current approaches to diagnosis and treatment]. Klinicheskaya medicyna, 86(11), 9–15. [in Russian].
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