The metabolism reactions mechanisms of 3-ethoxozepam in rat liver homogenates
DOI:
https://doi.org/10.14739/2310-1210.2015.4.50250Keywords:
Ethoxazepam, Metabolism, In VitroAbstract
7-bromo-5-phenyl-3-ethoxy-1,2-dihydro-3H-1,4-benzdiazepine-2-on (ethoxozepam) is one of promising possible drugs with analgesic activity.
The aim of the work was studying of 14C-ethoxozepam possible metabolism pathways in vitro and estimating their efficacy in rat liver homogenate.
Methods and results. Using preparative thin-layer radiochromatography the fact of radioizotope label (in alcoxy group) elimination from molecule had been found.
Conclusions. The process intensity is in range 37,1±11,7% of the total maximal biotransformation of lipophilic metabolites. The possible metabolism scheme, through intermediate, hydroxylated in the heteroring 3 position, been suggested.
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