Influence of diuretics with antialdosterone effect on the condition of extracellular matrix and early postinfarction remodeling of the left ventricle in patients with Q-wave myocardial infarction
DOI:
https://doi.org/10.14739/2310-1210.2015.4.50259Keywords:
Collagen, Matrix Metalloproteinase-9, Tissue Inhibitor Of Metalloproteinase-1Abstract
Objective. Aldosterone receptor blockade regulate activity of matrix metalloproteinase system, increase survival in postinfarction period.
Methods and results. In order to study the influence of aldosterone receptor blockade on the serum level of collagen of I and III types, condition of MMP/TIMP system, early postinfarction remodeling of the left ventricle after Q-wave myocardial infarction was studied in 89 patients. The next methods were used: immunoassay analysis of the serum levels of matrix metalloproteinase and its inhibitor, echocardiography. Also systolic and diastolic heart functions were assessed.
Conclusion. Under the influence of the treatment it was showed that the intensity of the degradation of connective tissue matrix of the myocardium reduced, and was accompanied by improvement of the left ventricular systolic and diastolic function.
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