Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis

Authors

  • O. S. Khukhlina
  • O. O. Ursul
  • V. S. Gaydichuk

DOI:

https://doi.org/10.14739/2310-1210.2015.4.50273

Keywords:

Chronic Obstructive Pulmonary Disease, Chronic Pancreatitis, Hepaval, Oxidative Stress

Abstract

Aim. To study the condition of oxidant-antioxidant system in patients with comorbid course of chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) with oral administration of glutathione.

Methods and results. 60 patients with COPD (GOLD1-2, В stage) were examined in the phase of non-infectious exacerbation with comorbid CP in the phase of exacerbation were divided into 2 groups. The main group (2, M) received therapy with hepaval (reduced glutathione per 250 mg twice a day) during 30 days. A tendency to increased activity of reduced glutathione in 1,2 and 1,6 times in the control and main groups was observed (р<0,05).

Conclusion. Treatment with hepaval promotes intensity of LPO processes decrease and restoration of the main factor of the antioxidant protective system in the blood – reduced glutathione.

References

Hubskyi, Yu. I. (2000). Biolohichna khimiia [Biological chemistry]. Kyiv; Ternopil. [in Ukrainian].

Boots, A. W., Haenen, G. R., & Bast, A. (2003). Oxidant metabolism in chronic obstructive pulmonary disease. Eur Respir J, 22(46), 14–27. doi:10.1183/09031936.03.00000403a.

Duthie, G. G., Arthur, J. R., & James, W. P. (1991). Effects of smoking and vitamin E on blood antioxidant status. Am J Clin Nutr, 53(106), 1–3.

Grigsby, B., Rodriguez-Rilo, H., & Khan, K. (2012). Antioxidants and chronic pancreatitis theory of oxidative stress and trials of antioxidant therapy. Digestive diseases and sciences, 57(4), 835–841. doi: 10.1007/s10620-012-2037-3.

Lomaestro, B. M., & Malone, M. (1995). Glutathione in health and disease: pharmaco therapeutic issues. Annals of Pharmacotherapy, 29(12), 63–73.

Birben, E., Sahiner, U. M., Sackesen, C., Erzurum, S., & Kalayci, O. (2012). Oxidative stress and antioxidant defense. WAO Journal, 5, 9–19. doi: 10.1097/WOX.0b013e3182439613.

Prousky, J. (2008). The Treatment of pulmonary diseases and respiratory-related conditions with inhaled (nebulized or aerosolized) glutathione. eCAM, 5(1), 27–35. doi: 10.1093/ecam/nem040.

Downloads

How to Cite

1.
Khukhlina OS, Ursul OO, Gaydichuk VS. Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis. Zaporozhye Medical Journal [Internet]. 2015Sep.16 [cited 2024Nov.5];17(4). Available from: http://zmj.zsmu.edu.ua/article/view/50273

Issue

No. 4 (2015): Zaporozhye medical journal

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)