Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis

Authors

  • O. S. Khukhlina
  • O. O. Ursul
  • V. S. Gaydichuk

DOI:

https://doi.org/10.14739/2310-1210.2015.4.50273

Keywords:

Chronic Obstructive Pulmonary Disease, Chronic Pancreatitis, Hepaval, Oxidative Stress

Abstract

Aim. To study the condition of oxidant-antioxidant system in patients with comorbid course of chronic obstructive pulmonary disease (COPD) and chronic pancreatitis (CP) with oral administration of glutathione.

Methods and results. 60 patients with COPD (GOLD1-2, В stage) were examined in the phase of non-infectious exacerbation with comorbid CP in the phase of exacerbation were divided into 2 groups. The main group (2, M) received therapy with hepaval (reduced glutathione per 250 mg twice a day) during 30 days. A tendency to increased activity of reduced glutathione in 1,2 and 1,6 times in the control and main groups was observed (р<0,05).

Conclusion. Treatment with hepaval promotes intensity of LPO processes decrease and restoration of the main factor of the antioxidant protective system in the blood – reduced glutathione.

References

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How to Cite

1.
Khukhlina OS, Ursul OO, Gaydichuk VS. Influence of exogenous glutathione on the system of antioxidant protection of the body in case of comorbid course of chronic obstructive pulmonary disease and chronic pancreatitis. Zaporozhye medical journal [Internet]. 2015Sep.16 [cited 2024Apr.16];17(4). Available from: http://zmj.zsmu.edu.ua/article/view/50273

Issue

No. 4 (2015): Zaporozhye medical journal

Section

Original research

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