Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy
DOI:
https://doi.org/10.14739/2310-1210.2015.4.50299Keywords:
Yakton, Mexicor, Glycolysis, Glyconeogenesis, Heart MitochondriaAbstract
Doxorubicin – basic drug for the neoplastic diseases treatment, it’s main adverse effect is cardiotoxicity. The development of this complication is connected with the energy metabolism, prooxidant-antioxidant homeostasis, disturbances and influence on the genetic apparatus.
The aim of the study – to state the succin acid’ derivatives – yakton and mexicor influence on indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy.
Results. In was found that myocardial pyruvate, malate, isocitrate, glycogen, glucose-6-phosphate level and malatdegidrogenase activity were decreased in rats with doxorubicin cardiomyopathy. In comparison lactate lactate level increased.
Conclusion. Succin acid’ derivatives – yakton and mexicor, administering with doxorubicin, protect glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium.
References
Vasyuk, Yu. A., Shkolnik, E. L., Nesvetov, V. V., Shkolnik, L. D., Varlan, G. V., Pilshchikov, A. V. (2012). Antraciklinovaya kardiotoksichnost': perspektivy ispol'zovaniya ivabradina [Anthracycline cardiotoxicity: Prospects for using ivabradine]. Cardoiоsоmаtiка, 4(3), 65–69 [in Russian].
Korokin, M. V., Pokrovskij, M. V., Konovalova, E. A., Savvin, V. A., Goncharov, N. F., & Denisyuk, T. A. (2012). Vozmozhnosti farmacevticheskoj korrekcii e′ndotelial'noj disfunkcii i koronarnogo krovotoka s pomosch'yu mildronata i meksikora [Possible pharmacological correction of endothelial dysfunction and coronary blood flow with mildronate and mexicor]. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta, 4(123), 189–197. [in Russian].
Pivnyuk, V. M., Ponomaryova, O. V., Yurchenko, O. V., Nosko, M. M., Dekhtyar, T. V., & Chekhun, V. F. (2013). Terapiya pacientov so zlokachestvennymi limfomami s ispol'zovaniem liposomal'noj formy doksorubicina: rezul'taty 15-letnego nablyudeniya [Therapy of malignant lymphoma using liposomal doxorubicin: results of 15-year follow-up]. Onkologiya, 14(2), 136–140. [in Russian].
Chekman, I. S., Horchakova, N. O., Nahorna, O. O., & Nebesna, T. Yu. (2008). Nikotynamid [Nicotinamide]. Kyiv: Polihrafplus. [in Ukrainian].
Chekman, I. S., Gorchakova, N. O., Francuzova, S. B., & Nagornaya, E. A. (2009). Metabolicheskie I metabolitotropnye preparaty v sisteme kardio- I organoprotekcii [Metabolic and metabolitotropic drugs in the system of cardio- and organoprotection]. Kyiv: Poligrafplus. [in Ukrainian].
Chekman, I. S., Gubskij, Yu. I., Gromov, L. A., & Belenichev, I. F. (2010). Doklinicheskoe izuchenie specificheskoj aktivnosti potencial’nykh nejroprotektivnykh preparatov [Preclinical study of the potential neuroprotective drugs specific activity]. Kyiv. [in Ukrainian].
Chekman, I. S., Maksymchuk, O. O., Horchakova, N. O., Belenichev, I. F., & Pavlov, S. V. (2011). Vplyv yaktonu na pokaznyky prooksydantno-antyoksydantnoho homeostazu, enerhetychnoho obminu ta protein-syntezu pry ftorydnii intoksykatsii [Yakton influence on prooxidant-antioxidant homeostasis energetic metabolism and proteinsynthesis in the rats condition of fluoride intoxication]. Naukovyi visnyk Natsionalnoho medychnoho universytetu imeni O.O. Bohomoltsia., 4, 275–279. [in Ukrainian].
Yakovleva, I. Yu., & Bielenichev, I. F. (2009). Neiroprotektyvna diia yaktonu [Neuroprotective action of yakton]. Visnyk problem biolohii i medytsyny, 1, 145–150. [in Ukrainian].
Belenichev, I. F., Kolesnik, N. N., Buchtiyarova, N. V., & Pavlov, S. V. (2012) Malate-aspartate shunt in neuronal adaptation to ischemic conditions: molecular-biochemical mechanisms of activation and regulation. Neurochemical Journal, 29(1), 28–34.
Mann, D. L., & Bristov, M. R. (2005). Mechanisms and models in heart failure” biomechanical model and beyond. Circulation, 111, 2837–2849. doi: 10.1161/CIRCULATIONAHA.104.500546.
Pinder, M. C., Duan, Z., Goodwin, J. S., Hortobagyi, G. N., & Giordano, S. H. (2007). Congestive heart failure in older women treated with ajuvantanthracycline chemotherapy for breast cancer. Clin .Oncol., 25, 3808–3815. doi:10.1200/JCO.2006.10.4976.
Trujillo, M., Naviliat, M., Alvarez, M. N., Peluffo, J. (2009). Peroxinitrite biochemistry – formation, reactions and detection. Analysis, 28(6), 518–528.
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