Research of the antimicrobial and antifungal activity of 7-((3-thio-4-R-4H-1,2,4-triazoles-3-yl)methyl)theophylline S-derivatives
DOI:
https://doi.org/10.14739/2310-1210.2015.4.50302Keywords:
1, 2, 4-triazoles, Theophylline, Antimicrobial, Antifungal ActivityAbstract
Aim. The research of antimicrobial and antifungal activity of 7-((3-thio-4-R-4H-1,2,4-triazoles-3-yl)methyl)theophylline S-derivatives has been erformed.
Methods and results. Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomоnas aeruginosa ATCC 27853, Candida albicans ATCC 885-653 have been taken as a set of standard test-strains. It has been proved that the most active alkyl-derivatives are 7-((3-thio-4-R-4H-1,2,4-triazole-3-yl)methyl)theophylline. Among the synthesized salts, which turned to be active against Staphylococcus aureus, the 2-(5-((theophylline-7-yl)methyl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetate ammonium has attracted our attention.
Conclusion. The perspective class of compounds for further research on this type of biological activity has been defined.
References
Volianskyi, Yu. L., Hrytsenko, I. S., Shyrobokov, V. P., et al. (2004) Vyvchennia spetsyfichnoi aktyvnosti protymikrobnykh likarskykh zasobiv [Studying of the specific activity of antimicrobial drugs].Kyiv. [in Ukrainian].
Kyreev, I. V. (2009) Issledovanie antibakterialnoj I fungistaticheskoj aktivnosti zameshchennykh i annelirovannykh proizvodnykh ksantina [Research of the antibacterial and fungystatic activity of substituted and anyllate ksantine derivatives]. Visnyk Sumskoho derzhavnoho universytetu, 1, 22–29. [in Ukrainian].
Nakaz Ministerstva okhorony zorovia Ukrainy Pro zatverdzhennia metodychnykh vkazivok «Vyznachennia chutlyvosti mikroorhanizmiv do antybakterialnykh preparativ 5 kvitnia 2007 roku №167 [Order of the Ministry of Health of Ukraine "On Approval of guidelines" Determining the sensitivity of microorganisms to antibiotics" from April 5 2007, №167] [in Ukrainian].
Bilyi, A. K., Kovalenko, S. I., Antypenko, L. M., Kamyshnyi, O. M., Polishchuk, N. M. (2013) Protyhrybkova ta protymikrobna aktyvnist {2-[3-heteryl-1N-1,2,4-triazol-5-il]fenil}aminiv i produktiv yikh heterotsyklizatsii [Antifungal and antimicrobial activity of {2-[3-heteryl-1H-1,2,4-triazoles-5-yl]phenyl}amine and products of their heterocyclization]. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 2(12), 80–82. [in Ukrainian].
Ruping, T., Linhong, J., Chengli, M., Juan, Y., Song, B., Deyu, H., et al. (2013) Synthesis, antifungal and antibacterial activity for novel amide derivatives containing a triazole moiety. Chemistry Central Journal, 7(30), 1–7. doi:10.1186/1752-153X-7-30.
Shobha, D., Umes, L., Rajani, B., & Shankar, B. (2013) Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives. Indian Journal of Chemistry, 52B(08), 1176–1181.
Kumari, S., Nitin, K., Sushma, D., & Pramod, K. S. (2011) Advances in synthetic approach to and antifungal activity of triazoles. J. Org. Chem., 7, 668–677. doi: 10.3762/bjoc.7.79.
Jacob, H. J., Fawzi, I. I., & Yaseen, A. A. (2013) Antibacterial activity of some selected 1,2,4-triazole derivatives against standard, environmental, and medical bacterial strains. Advanced Studies in Biology, 5(6), 291–301. http://dx.doi.org/10.12988/asb.2013.3418.
Sumitra, C., Yogesh, B., & Shipra, B. (2010) Synthesis and antibacterial activity of some new triazole derivatives. Archives of Applied Science Research, 2(3), 117–126.
Waled, A. E., Eman, M. F., & Eman, M. H. (2012) Anticancer and antimicrobial activities of some synthesized pyrazole and triazole derivatives. Der Pharma Chemica, 4(1), 23–32.
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