The influence of comorbid pathology on expressiveness of inflammatory process in patients with lower respiratory tract infections

Authors

  • T. O. Pertseva
  • T. V. Kireyeva
  • O. O. Shtepa

DOI:

https://doi.org/10.14739/2310-1210.2015.4.50306

Keywords:

Pneumonia, Hypertension, Surfaktant Protein D, Protein, Pulmonary Disease, Chronic Obstructive

Abstract

Aim of the research was to define the influence of comorbid pathology on expressiveness of an inflammation.

Methods and results. 59 persons with community acquired pneumonia (CAP) and acute exacerbation of COPD (AE COPD) were included. The diagnostic significance of CR-P and SP-D markers was studied with Immunoassay methods considering comorbid arterial hypertension (AH). The existence of comorbid AH in patients with CAP and AE COPD is followed by a tendency to higher figures of C-RP and reliable increase of the SP-D levels.

Conclusion. Acute process is characterized by reliably higher meanings of markers, as compared with exacerbation of the chronic process.

References

Vіzіr, V. A., Goncharov, O. V., & Sadomov, A. S. (2013) Osoblivostі prozapal'noї aktivatsії ta їїrol' v patogenezіsertsevo-sudinnogo remodelyuvannya u khvorikh na gіpertonіchnu khvorobu ІІ stadії [Features of the pro-inflammatory activation and its role in the pathogenesis of cardiovascular remodeling in hypertensive patients of the II nd stage]. Zaporozhskij medicinskij zhurnal, 4(79), 5–9. [in Ukrainian].

Krivenko, V. V. (2013) Systemne zapalennia ta morfofunktsіonal'nі parametry mіokarda і sudyn u khvorykh z poiednanym perebіhom khronіchnoho obstruktyvnoho zakhvoriuvannia legen ta hіpertonіchnoi khvoroby [Systemic inflammation and morphological parameters of the myocardium and blood vessels in patients with combined course of chronic obstructive pulmonary disease and hypertension]. Zaporozhskij medicinskij zhurnal, 3(78), 43–46. [in Ukrainian].

Ostrovskyi, M. M., & Herych, P. R. (2011) Do pytannia polimorbidnosti ta komorbidnosti u khvorykh na KhOZL [The issue of polymorbidity and comorbidity in patients with COPD]. Ukrainskyi pulmonolohichnyi zhurnal, 4, 19–24. [in Ukrainian].

Smetneva, N. S., Vikent'ev, V. V., Zav'yalova, S. A., Popkova, A. V., & Malyshev, I. Yu. (2013) Rol' vospalitel'nykh faktorov v razvitii serdechno-sosudistoj patologii pri khronicheskoj obstruktivnoj bolezni legkikh [Role of inflammatory factors in development of cardiovascular pathology at a chronic obstructive pulmonary disease]. Medicinskie nauki, 3,162–166. [in Russian].

Corrales-Medina, V. F., Musher, D. M., Wells, G. A., Chirinos, J. A., Chen, L., Fine, M. J. (2012) Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality. Circulation, 125, 773–781. doi: 10.1161/CIRCULATIONAHA.111.040766.

Hill, J., Heslop, C., Man, S. F. P., et al. (2011) Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality. Eur Heart J., 124, 11–24.

Lee, M. Y. K., Sørensen, G. L., Holmskov, U., & Vanhoutte, P. M. (2009) The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging. Molecular immunology, 46(6), 1050–1057. doi: 10.1016/j.molimm.2008.09.027.

Mandal, P., Chalmers, J. D., Choudhury, G., Akram, A. R., & Hill, A. T. (2011) Vascular complications are associated with poor outcome in community-acquired pneumonia. QJM, 104, 489–495. doi: 10.1093/qjmed/hcq247.

Marincu, I., Bertici, N., Mihaicuta, S., Mavrea, A., & Tomescu, M. (2014) The prevalence of cardiac diseases in patients with community-acquired pneumonia. ERJ., 44(58), 25–77.

Woodhead, M., Blasi, F., Ewig, S., Garau, J., Huchon, G., Ieven, M., et al. (2011) Joint Taskforce of the European Respiratory Society and European Society for Clinical Microbiology and Infectious Diseases: guidelines for the management of adult lower respiratory tract infections. Clin. Microbiol. Infect., 17(6), 1–59. doi: 10.1111/j.1469-0691.2011.03672.x.

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How to Cite

1.
Pertseva TO, Kireyeva TV, Shtepa OO. The influence of comorbid pathology on expressiveness of inflammatory process in patients with lower respiratory tract infections. Zaporozhye Medical Journal [Internet]. 2015Sep.16 [cited 2024Nov.5];17(4). Available from: http://zmj.zsmu.edu.ua/article/view/50306

Issue

No. 4 (2015): Zaporozhye medical journal

Section

Original research

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