Idiopathic thrombocytopenic purpura. Clinical case

Authors

  • V. V. Syvolap Zaporizhzhia State Medical University,
  • Ye. V. Novikov Zaporizhzhia State Medical University,
  • O. G. Onishko Primorsk central district hospital,

DOI:

https://doi.org/10.14739/2310-1210.2015.5.53720

Keywords:

Idiopathic Thrombocytopenic Purpura, Thrombocytopenia, Hemorrhagic Syndrome, Pathogenesis, Diagnostics, Treatment

Abstract

Aim. To draw the attention of physicians - internists to the problem of thrombocytopenia and hemorrhagic vasculitis. To describe the clinical case of idiopathic thrombocytopenic purpura, features of diagnostics and treatment of this disease at various stages of medical care, to highlight some aspects of the epidemiology, pathogenesis, modern diagnostics and treatment of disease.

Methods and results. The article describes a clinical case of disease in a woman of 30 years. The diagnosis was set based on an analysis of complaints and a history of the disease; identify the classic rash of microcirculatory type on the skin as well as the results of additional investigation. The basic stages of diagnostic search and conducted differential diagnosis, the dynamics of the patient, laboratory parameters and the results of instrumental examination are presented. The treatment and its results are briefly described.

Conclusion. Always try to determine the cause of thrombocytopenia. The clinical case and some highlighted aspects of the modern treatment and emergency care of hemorrhagic syndrome, caused by decreasing of  platelet count should help practicing physicians to help such patients.

References

Vinogradov, A. V. (1987). Differencial'nyj diagnoz vnutrennikh boleznej [Differential diagnosis of internal diseases]. Moscow: Medicina. [in Russian].

Gajdukova, S. N., Sidorenkov, A. V., Sivak, L. A., & Vydyborec, S. V. (2003). Idiopaticheskaya trombocitopenicheskaya purpura u detej [Idiopathic thrombocytopenic purpura in children]. Problemy viiskovoi okhorony zdorovia, 13, 120–30. [in Ukrainian].

Zotikov, E. A., Babaeva, A. G., & Golovkina, L. L. (2003). Trombocity i antitrombocitarnye antitela [Platelets and antiplatelet antibodies]. Moscow: Monolit. [in Russian].

Sokolova, M. Yu. (2003). Idiopaticheskaya trombocitopenicheskaya purpura i gestacionnyj process [Idiopathic thrombocytopenic purpura and the gestational process]. Terapevticheskij arkhiv, 78(10), 45–50. [in Russian].

Watanabe, M., Fujimoto, T., Iwano, M., Shiiki, H., & Nakamura, S. (2002). Report of a patient of primary Sjoegren syndrome, IgA nephropathy and chronic idiopathic thrombocytopenic purpura. Japanese Journal of Clinical Immunology, 25(2), 191–198. doi: 10.2177/jsci.25.191.

Kohda, K., Kuga, T., Kogawa, K., Kanisawa, Y., Koike, K., Kuroiwa, G., et al. (2002). Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura. British Journal of Haematology, 118(2), 584–588.

Michel, M., Khellaf, M., Desforges, L., Lee, K., Schaeffer, A., Godeau, B., & Bierling, P. (2002). Autoimmune Thrombocytopenic Purpura and Helicobacter pylori Infection. Arch Intern Med, 162(9), 1033–1033.

Vorob'ev, A. I. (Ed.). (2005). Rukovodstvo po gematologii [Guide to Hematology]. (Vol. 3). Moscow: N'yudiamed. [in Russian].

Huhn, R. D., Fogarty, P. F., Nakamura, R., Read, E. J., Leitman, S. F., Rick M. E., et al. (2003). High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia. Blood, 101(1), 71–77. doi: 10.1182/blood-2001-12-0171.

Vashhenko, T. F., Dolgina, E. N., Kislyak, N. S., Kuznecov, V. P., Plahuta, T. G., Cymbal, I. N., & Borodina, T. M. (1999). Znachenie immunokorrigiruyushhej terapii preparatami interferona v lechenii idiopaticheskoj trombocitopenicheskoj purpury u detej [The value of immunotherapy interferon drugs in the treatment of idiopathic thrombocytopenic purpura in children]. Gematologiya i transfuziologiya, 44(1), 9–14. [in Russian].

Zaharov, G. N., Gotman, L. N., & Mikhajlova, E. A. (2002). Otdalennye rezul'taty transkateternoj okklyuzii selezenochnoj arterii (TOSA) pri aplasticheskoj anemii (AA) i idiopaticheskoj trombocitopenicheskoj purpure (ITP) [Long-term results of transcatheter occlusion of the splenic artery (TOSA) with aplastic anemia (AA) and idiopathic thrombocytopenic purpura (ITP)]. Problemy gematologii i perelivaniya krovi, 1, 28–29. [in Russian].

Kurtov, I. V. (2002). Dispansernoe nablyudenie bol'nykh idiopaticheskoj trombocitopenicheskoj purpuroj (ITP) v otdalennom periode posle splene′ktomii [Dispensary observation of patients with idiopathic thrombocytopenic purpura (ITP) in the late period after splenectomy]. Problemy gematologii i perelivaniya krovi, 1, 51. [in Russian].

How to Cite

1.
Syvolap VV, Novikov YV, Onishko OG. Idiopathic thrombocytopenic purpura. Clinical case. Zaporozhye Medical Journal [Internet]. 2015Nov.20 [cited 2024Nov.25];17(5). Available from: http://zmj.zsmu.edu.ua/article/view/53720

Issue

Section

Practical observations