Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction

Authors

  • V. A. Vasylenko Dnipropetrovsk Medical Academy Ministry of Health Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2015.5.53746

Keywords:

Congestive Heart Failure, Spironolactone, NT-proBNP

Abstract

Existing recommendations on the mineralocorticoid/aldosterone receptor antagonists have been developed only for patients with systolic heart failure, and all outcome trials performed in patients with preserved ejection fraction failed to improve prognosis in this condition.

Аim. To examine the effectiveness of spironolactone therapy in elderly patients with chronic heart failure NYHA I–II with preserved left ventricular ejection fraction.

Methods and results. Peculiarities of transmitral diastolic blood flow was studied with Doppler echocardiography. 6-min walk test and NT-proBNP was performed for the assessment of clinical course improvement in such patients.

Conclusion. It was found that spironolactone therapy improves mitral diastolic blood flow, reduces concentration of NT-proBNP, which correlates with improved clinical course of heart failure.

References

Mosterd, A., & Hoes, A. W. (2007) Clinical epidemiology of heart failure. Heart, 93, 1137–1146. doi:10.1136/hrt.2003.025270.

McMurray, J. J., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., et al. (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J, 33(14), 1787–1847. doi: 10.1093/eurheartj/ehs104.

Owan, T. E., Hodge, Do., Herges, R. M., Jacobsen, S. J., Roger, V. L., & Redfield, M. M. (2006). Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med, 355, 251–259. doi: 10.1056/NEJMoa052256.

Bhatia, R. S., Tu, J. V., Lee, D. S., Austin, P. C., Fang, J., Haouzi, A., et al. (2006) Outcome of heart failure with preserved ejection in a population-based study. N Engl J Med, 355, 260–269. doi:10.1056/NEJMoa051530.

Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). (2012) The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data metaanalysis. Eur Heart J, 33, 1750–1757. doi: 10.1093/eurheartj/ehr254.

Cleland, J. G., & Pellicori, P. (2013) Defining diastolic heart failure and identifying effective therapies. JAMA, 309(8), 825–826. doi: 10.1001/jama.2013.1569.

Yusuf, S., Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., et al. (2003) Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet, 362, 777–781.

Massie, B. M., Carson, P. E., McMurray, J. J., Komajda, M., McKelvie, R., Zile, M. R., et al. (2008) Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med, 359, 2456–2467. doi: 10.1056/NEJMoa0805450.

Cleland, J. G., Tendera, M., Adamus, J., Freemantle, N., Polonski, L., & Taylor, J. (2006) The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J, 27, 2338–2345. doi:10.1093/eurheartj/ehl250.

Ingle, L., Shelton, R. J., Rigby, A. S., Nabb, S., Clark, A. L., & Cleland, J. G. F. (2005) The reproducibility and sensutivity of the 6-min walk-test in elderly patients with chronic heart failure. Eur Heart J, 26, 1742–1751. doi:10.1093/eurheartj/ehi259.

Devereux, R. B., Alonso, D., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol, 57, 450–458.

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How to Cite

1.
Vasylenko VA. Effect of spironolactone on transmitral diastolic blood flow and course of chronic heart failure with preserved left ventricular ejection fraction. Zaporozhye Medical Journal [Internet]. 2015Nov.20 [cited 2024Nov.25];17(5). Available from: http://zmj.zsmu.edu.ua/article/view/53746

Issue

No. 5 (2015): Zaporozhye medical journal

Section

Original research

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