Relationship between lipid profile, cardiac hemodynamics status and autoimmune activation markers in patients with ischemic heart disease, accompanied with hypothyroidism

Authors

  • N. S. Mykhailovska Zaporizhzhia State Medical University,
  • T. V. Oliynyk Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2310-1210.2015.6.56303

Keywords:

Lipids, Cardiac Remodeling, Hemodynamic, Biological Markers, Coronary Disease, Hypothyroidism

Abstract

Presence of hypothyroidism in patients with coronary heart disease contribute to its progression. Aim. Study purpose was exploring the features of changes in lipid profile, cardiac hemodynamics status, autoimmune activation markers and their relationships in patients with coronary heart disease, accompanied with hypothyroidism. Methods and results. 64 patients were examined. The levels of thyroid-pituitary hormones, concentration of tumor necrosis factor-α, C-reactive protein, endothelin-1, an inhibitor of plasminogen activator-1, neopterin were examined by ELISA. Structural and functional heart features were studied with doppler echocardiography. It was found that patients with coronary heart disease, accompanied with hypothyroidism, had more expressed lipid disorders, heart restructuring such as increased end - diastolic volume, end - diastolic pressure, myocardial mass and stiffness index on the background of immunoinflammatory activation and endothelial dysfunction. Conclusions. It was found correlation between markers of endothelial dysfunction immunoinflammatory activation and lipid profile, heart structural and functional state.

References

Heron, M. (2009). Death: Leading Causes for 2009. National Vital Statistics Reports., 61(7), 3–96.

Mitchenko, O. I., Lohvynenko, A. O., & Romanov, V. Yu. (2010) Optymizatsiia likuvannia dyslipidemii ta porushen vuhlevodnoho obminiv u khvorykh z metabolichnym syndromom ta dysfunktsiieiu shchytopodibnoi zalozy [Optimization of treatment of dyslipidemia and disorders of carbohydrate metabolism in patients with metabolic syndrome and thyroid dysfunction]. Ukrainskyi kardiolohichnyi zhurnal, 1, 73–80. [in Ukrainian].

Pankiv, V. (2012). Syndrom hipotyreozu [Hypothyroidism syndrome]. Mezhdunarodnyj e′ndokrinologicheskij zhurnal, 5(45), 136–148. [in Ukrainian].

D'Alessandris, C., Lauro, R., Presta, I., & Sesti, G. (2007). C–reactive protein induces phosphorylation of insulin receptor substrate–1 Ser (307) and Ser (612) in L6 myocytes, thereby impairing the insulinsignalling pathway that promotes glucose transport. Diabetologia, 50(4), 840–849. doi: 10.1007/s00125-006-0522-y.

Degtyareva, O., & Petyunina, O. (2008). Syvorotochnyj neopterin i C-reaktivnyj belok u bol′nykh s raznymi klinicheskimi variantami ostrogo koronarnogo sindroma [Serum neopterin and C-reactive protein in patients with different clinical types of acute coronary syndrome]. Ukrainskyi terapevtychnyi zhurnal, 1, 41–44. [in Ukrainian].

Adachi, T., Naruco, T., Itoh, A., Komatsu, R., Abe, Y. Shirai, N., et al. (2007). Neopterin is associated with plaque inflammation and destabilization in human coronary atherosclerotic lesions. Heart, 93, 1537–1541. doi: 10.1136/hrt.2006.109736.

Scirica, B., & Morrow, D. (2006). Is C-reactive protein an innocent bystander or proatherogenic culprit? The verdict is still out. Circulation, 113, 2128–2134.

Dorzhieva, L. V., Kushkhova, D. Kh., Orlova, O. V., & Shevchenko, O. P. (2007). Klinicheskoe i diagnosticheskoe znachenie urovnya neopterina u bol′nykh s ishemicheskoj bolezn′yu serdca [Clinical and diagnostic value of neopterin levels in patients with coronary heart disease]. Kardiovaskulyarnaya terapiya i profilaktika, 5, 88–89. [in Russian].

Zueva, O. M., & Malahova, Yu. I. (2012). Vozrastnye i sezonnye kharakteristiki pokazatelej gipofizarno-tireoidnoj, lipidotransportnoj i immunnoj sistem u zdorovykh muzhchin [Age and seasonal characteristics of indicators pituitary-thyroid, lipid transport and immune systems in healthy men]. Omskij nauchnyj vestnik. Seriya: Resursy Zemli. Chelovek, 2(114), 113–116. [in Russian].

Valgimigli, M., Percoco, G., Malagutti, P., Campo, G., Ferrari, F., Barbieri, D., et al. (2005). Tirofiban and sirolimus-eluting stent vs abciximab and bare-metal stent for acute myocardial infarction: a randomized trial. JAMA, 293(17), 2109–2117. doi: 10.1001/jama.293.17.2109.

Nystrom, T., Sjoholm, A., & Nygren, A. (2005). Persistent endothelial dysfunction is related to elevated C-reactive protein levels in type II diabetic patients after acute myocardial infarction. Clin. Science, 108, 121–128.

Vieira, S., Lemos, H., Grespan, R., Napimoga, M., Dal-Secco, D., Freitas, A., et al. (2009). A crucial role for TNF-α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5. British Journal of Pharmacology, 158(3), 779–789. doi: 10.1111/j.1476-5381.2009.00367.x

Van den Oever, I., Raterman, H., Nurmohamed, M., & Simsek, S. (2010). Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus. Mediators of Inflammation, 2010, 792393. doi: 10.1155/2010/792393.

El′skij, V. N., Vatutin, N. T., Kalinkina, N. V., & Salahova, A. M. (2008). Rol′ disfunkcii e′ndoteliya v geneze serdechno-sosudistykh zabolevanij [The role of endothelial dysfunction in the pathogenesis of cardiovascular disease]. Zhurnal AMN Ukrainy, 14(1), 51–62. [in Ukrainian].

Ruzhencova, U. Yu. (2008). Vzaimosvyaz mezhdu simpaticheskoj nervnoj sistemoj i e′ndotelinom-1 v kapillyarnom krovotoke u bol′nykh ishemicheskoj bolezn′yu serdca – znachenie GNB3 S825T polimorfizma [The relationship between the sympathetic nervous system and endothelin-1 in the capillary blood flow in patients with coronary heart disease - the value GNB3 S825T polymorphism]. Lechaschij vrach, 1, 87–92. [in Russian].

Lien, E., Nedrebø, B. G., Varhaug, J. E., Nygård, O., Aakvaag, A., & Ueland, P. M. (2000). Plasma total homocysteine levels during short-term iatrogenic hypothyroidism. J Clin Endocrinol Metab., 85(3), 1049–1053. doi: 10.1210/jcem.85.3.6439.

Yazbeck, R., Benoit, P., Roche, B., Boeglin, M. B., Tauveron, I., & Thieblot, P. (2001). Primary hypothyroidism in the adult older than 60 years: characteristics and follow-up after initiation of replacement treatment in hospital. Presse-Med., 30(24), 1193–1198.

Gunduz, M., Gunduz, E., Kircelli, F., Okur, N., & Ozkaya, M. (2012). Clinical Study: role of surrogate markers of atherosclerosis in clinical and subclinical thyroidism. Int J Endocrinol., 2012(109797), 1–6. doi: 10.1155/2012/109797.

Ness, G., & Lopez, D. (1995). Transcriptional regulation of rat hepatic low-density lipoprotein receptor and cholesterol 7б hydroxylase by thyroid hormone. Arch Biochem Biophys, 323, 404–408.

Auer, J., Berent, R., Weber, T., Lassnig, E., & Eber, B. (2003). Thyroid function is associated with presence and severity of coronary atherosclerosis. Clin. Cardiol, 26(12), 569–573.

Michalaki, M., Vagenakis, A., Leonardou, A., Argentou, M. N., Habeos, I. G., Makri, M. G., et al. (2006). Thyroid function in humans with morbid obesity. Thyroid, 16(1), 73–78. doi: 10.1089/thy.2006.16.73.

Bamashmoos, S., Al-Nuzaily, M., Al-Meeri, A., & Ali, F. (2013). Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients. SpringerPlus, 2(1), 423. doi: 10.1186/2193-1801-2-423.

Rodondi, N., Newman, A., Vittinghoff, E., de Rekeneire, N., Satterfield, S., Harris, T., & Bauer, D. (2005). Subclinical Hypothyroidism and the Risk of Heart Failure, Other Cardiovascular Events, and Death. Arch Intern Med, 165(21), 2460–2466. doi: 10.1001/archinte.165.21.2460.

Walsh, J., Bremner, A., Bulsara, M., O’Leary, P., Leedman, P., Feddema, P., & Michelangeli, V. (2005). Subclinical Thyroid Dysfunction as a Risk Factor for Cardiovascular Disease. Arch Intern Med, 165(21), 2467–2472. doi: 10.1001/archinte.165.21.2467.

Hueston, W., King, D., & Geesey, M. (2005). Serum biomarkers for cardiovascular inflammation in subclinical hypothyroidism. Clin Endocrinol, 63(5), 582–587. doi: 10.1111/j.1365-2265.2005.02388.x.

Tuzcu, A., Bahceci, M., Gokalp, D., Tuzun, Y., & Gunes, K. (2005). Subclinical Hypothyroidism may be Associated with Elevated High-sensitive C-Reactive Protein (Low Grade Inflammation) and Fasting Hyperinsulinemia. Endocrine Journal, 52(1), 89–94. doi: 10.1507/endocrj.52.89.

Taddei, S., Caraccio, N., Virdis, A., Dardano, A., Versari, D., Ghiadoni, L., et al. (2006). Low-Grade Systemic Inflammation Causes Endothelial Dysfunction in Patients with Hashimoto’s Thyroiditis. The Journal of Clinical Endocrinology & Metabolism, 91(12), 5076–5082. doi: 10.1210/jc.2006-1075.

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1.
Mykhailovska NS, Oliynyk TV. Relationship between lipid profile, cardiac hemodynamics status and autoimmune activation markers in patients with ischemic heart disease, accompanied with hypothyroidism. Zaporozhye medical journal [Internet]. 2015Dec.29 [cited 2024Apr.16];17(6). Available from: http://zmj.zsmu.edu.ua/article/view/56303

Issue

No. 6 (2015): Zaporozhye medical journal

Section

Original research

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