Assessment of renal dysfunction in patients with cirrhosis

Authors

  • A. S. Tugushev Zaporizhzhia State Medical University,
  • A. V. Bolgova SD «Local Clinical Hospital on the Station Zaporizhzhia-2 of the Pridneprovsky Railway»,
  • T. V. Ermakova SD «Local Clinical Hospital on the Station Zaporizhzhia-2 of the Pridneprovsky Railway»,
  • D. A. Nosov SD «Local Clinical Hospital on the Station Zaporizhzhia-2 of the Pridneprovsky Railway»,
  • L. A. Chubich Zaporizhzhia Regional Psychiatric Hospital,

DOI:

https://doi.org/10.14739/2310-1210.2015.6.57046

Keywords:

Cirrhosis, Kidney Diseases, Creatinine, Cystatin C, Glomerular Filtration Rate

Abstract

Emergence of renal dysfunction in cirrhosis is an integral part of a natural course of the disease characterizing its weight. In turn, development of renal dysfunction is considered one of the pathogenetic moments of development of the main complications of cirrhosis. Thus principles of diagnostics of renal dysfunction fully are not defined today.

Aim. For the purpose of an assessment of diagnostic importance of laboratory criteria violation of secretory function of kidneys in patients with the complicated course of cirrhosis we investigated kidneys function in 120 patients with decompensated cirrhosis depending on positive or negative result of treatment.

Methods and results. Laboratory researches included definition of a creatinine, sodium and potassium in blood and urine, glomerular filtration rate (GFR), clearance of an endogenous creatinine and serum cystatin C level. It is established that serum cystatin C level is the most informative criterion of assessment of the renal dysfunction and it can be used as a criterion of efficiency of treatment and prognosis of the clinical course.

Conclusion. This indicates the importance of renal dysfunction in development of cirrhosis complications .

References

Zavhorodnii, S. M., Tuhushev, A. S., & Mikhantiev, D. I. (2013). Diahnostyka, likuvannia ta profilaktyka nyrkovoi dysfunktsii pry tsyrozi pechinky [Diagnosis, treatment and prevention of renal dysfunction in liver cirrhosis]. Kyiv. [in Ukrainian].

Kayukov, I. G., Smirnov, A. V., & Emanuel, V. L. (2012). Cistatin C v sovremennoj medicine [Cystatin in current medicine]. Nefrologiya, 16(1), 22–39. [in Russian].

Mikhaleva, L. L., Zolotavina, M. L., & Khablyuk, V. V. (2012) Cistatin C – nadezhnyj biokhimicheskij indikator narusheniya fil'tracionnoj funkcii pochek u detej [Cystatin-C as the reliable biochemical indicator of kidneys filtrational function disturbances in children]. Sovremennye problemy nauki i obrazovaniya, 5, 7–9. [in Russian].

Angeli, P., Sanyal, A., Moller, S., Alessandria, C., Gadano, A., Kim, R., et al. (2013). Current limits and future challenges in the management of renal dysfunction in patients with cirrhosis: report from the International Club of Ascites. Liver International, 33(1), 16–23. doi: 10.1111/j.1478-3231.2012.02807.x.

Arroyo, V. (2013). Acute kidney injury (AKI) in cirrhosis: Should we change current definition and diagnostic criteria of renal failure in cirrhosis? Journal of Hepatology, 59(3), 415–417. doi: 10.1016/j.jhep.2013.05.035.

Belcher, J. M., Parikh, C. R., & Garcia-Tsao, G. (2013). Acute Kidney Injury in Patients With Cirrhosis: Perils and Promise. Clinical Gastroenterology and Hepatology, 11(12), 1550–1558. doi: 10.1016/j.cgh.2013.03.018.

Ćulafić, Đ., Štulić, M., Obrenović, R., Miletić, D., Mijač, D., Stojković, M., et al. (2014). Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. World Journal of Gastroenterology, 20(21), 6573–6579. doi: 10.3748/wjg.v20.i21.6573.

De Souza, V., Hadj-Aissa, A., Dolomanova, O., Rabilloud, M., Rognant, N., Lemoine, S., & Radenne, S. (2014). Creatinine- versus cystatine C-based equations in assessing the renal function of candidates for liver transplantation with cirrhosis. Hepatology, 59(4), 1522–1531. doi: 10.1002/hep.26886.

Fagundes, C., Barreto, R., Guevara, M., Garcia, E., Solà, E., Rodríguez, E., et al. (2013). A modified acute kidney injury classification for diagnosis and risk stratification of impairment of kidney function in cirrhosis. Journal of Hepatology, 59(3), 474–481. doi: 10.1016/j.jhep.2013.04.036.

Francoz, C., Glotz, D., Moreau, R., & Durand, F. (2010). The evaluation of renal function and disease in patients with cirrhosis. Journal of Hepatology, 52(4), 605–613. doi: 10.1016/j.jhep.2009.11.025.

Gerhardt, T., Pöge, U., Stoffel-Wagner, B., Palmedo, H., Sauerbruch, T., & Woitas, R. P. (2011). Creatinine-based glomerular filtration rate estimation in patients with liver disease. European Journal of Gastroenterology & Hepatology, 23(11), 969–973. doi: 10.1097/MEG.0b013e32834991f1.

Hoek, F. J., Kemperman, F. A., & Krediet, R. T. (2003). A comparison between cystatin C, plasma creatinine and the Cockcroft and Gault formula for the estimation of glomerular filtration rate. Nephrology Dialysis Transplantation, 18(10), 2024–2031. doi: 10.1093/ndt/gfg349.

John, S., & Thuluvath, P. J. (2015). Hyponatremia in cirrhosis: Pathophysiology and management. World J Gastroenterol., 21(11), 3197–3205. doi: 10.3748/wjg.v21.i11.3197.

Ohashi, N., Tsuji, N., Naito, Y., Iwakura, T., Isobe, S., Ono, M., et al. (2013). Relationship between urinary fractional excretion of sodium and life prognosis in liver cirrhosis patients. Hepatology Research, 43(11), 1156–1162. doi: 10.1111/hepr.12068.

Parke, Ch. Y., Martin, P., & Bunnapradis, S. (2015). Renal dysfunction in cirrhosis. Clinical Liver Disease, 5(6), 150–157.

Runyon, B. A. (2013). Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012. Hepatology, 57(4), 1651–1653. doi: 10.1002/hep.26359.

Seo, Y. S., Jung, E. S., An, H., Kim, J. H., Jung, Y. K., Kim, J. H., et al. (2009). Serum cystatin C level is a good prognostic marker in patients with cirrhotic ascites and normal serum creatinine levels. Liver International, 29(10), 1521–1527. doi: 10.1111/j.1478-3231.2009.02105.x.

Downloads

How to Cite

1.
Tugushev AS, Bolgova AV, Ermakova TV, Nosov DA, Chubich LA. Assessment of renal dysfunction in patients with cirrhosis. Zaporozhye medical journal [Internet]. 2015Dec.29 [cited 2024Apr.24];17(6). Available from: http://zmj.zsmu.edu.ua/article/view/57046

Issue

No. 6 (2015): Zaporozhye medical journal

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)