Features of aldosterone antagonists in the treatment of patients with acute myocardial infarction with ST elevation without chronic heart failure and post-MI chronic heart failure with low ejection fraction

Authors

  • V. V. Syvolap Zaporizhzhia State Medical University,
  • L. V. Lukashenko Zaporizhzhia State Medical University,
  • S. P. Zhemanyuk Zaporizhzhia State Medical University,
  • M. P. Gerasko Zaporizhzhia State Medical University,
  • L. V. Franskyavichene Municipal Hospital № 10, Zaporizhzhia,

DOI:

https://doi.org/10.14739/2310-1210.2015.6.57363

Keywords:

Myocardial Infarction, Acute Disease, Randomized Controlled Trials as Topic, Aldosterone

Abstract

Aim. In order to study the possibilities of aldosterone antagonists in the treatment of patients with acute myocardial infarction with ST elevation without chronic heart failure and post-MI chronic heart failure with low ejection fraction recent researches on this problem were reviewed. The literature data and the results of multicenter randomized controlled trials (RCTs), which will expand not only the understanding of the mechanisms of action of aldosterone receptor antagonists, but also new areas of their application in clinical practice, were analyzed.

Conclusions. Randomized studies have shown that the efficiency of the selective aldosterone antagonist eplerenone has advantages over spironolactone in the improvement of prognosis in post-MI patients with LV systolic dysfunction and/or clinical signs of heart failure.

References

Dzyak, G. V., & Vasil'eva, A. A. (2009) Blokada rennin-angiotenzin-al'dosteronovoj sistemy kak kraeugol'nyj kamen' lecheniya serdechnoj nedostatochnosti [The blockade of the rennin-angiotensin-aldosterone system as a cornerstone of the treatment of heart failure]. Sertseva nedostatnist, 1, 18–30. [in Ukrainian].

Voronkov, L. G. (2008) Khronicheskaya serdechnaya nedostatochnost' : rukovodstvo po kardiologii [Chronic heart failure: A Guide to Cardiology]. Kyiv: Morion. [in Ukrainian].

Tashchuk, V. K., Polіanska, O. S., & Gulaga, O. I. (2013) Tryvale sposterezhennia za khvorymy na hostryi infarkt miokarda pry vykorystanni antahonistiv aldosteronu [A Prolonged follow-up of patients with acute myocardial infarction with using aldosterone antagonists]. Bukovynskyi medychnyi visnyk, 17, 2(63), 132–135. [in Ukrainian].

Booth, E., & Johnson, J. P. (2012) Aldosterone. Adv. Ohysil. Educ., 26, 8–20.

Berezin, A. E. (2008) Diastolicheskaya serdechnaya nedostatochnost': fenotipicheskaya osobennost' ili novoe kardiovaskulyarnoe zabolevanie? [Diastolic heart failure: phenotypic feature or new cardiovascular disease]. Ukrainskyi medychnyi chasopys, 2(64), 81–89. [in Ukrainian].

Rybakova, M. K., Alekhin, M. N., & Mit'kov, V. V. (2008) Prakticheskoe rukovodstvo po ul'trazvukovoj diagnostike. E′khokardiografiya [A practical guide to ultrasound. Echocardiography]. Moscow : Vidar. [in Russian].

Kovalenko, V. M., Lutai, M. I., & Sirenko, Yu. M. (Eds.) (2010) Sertsevo-sudynni zakhvoriuvannia. Klasyfikatsiia, standarty diahnostyky ta likuvannia [Cardiovascular disease. The classification standards for diagnosis and treatment]. Kyiv. [in Ukrainian].

Nishimura, R. A., & Jaber, W. (2007) Understanding “diastolic heart failure”. The tip of the iceberg. J. Amer. Coll. Cardiol., 49(6), 695–697. doi:10.1016/j.jacc.2006.11.014.

Persson, H., Lonn, E., Edner, M., Baruch, L., Lang, C. C., Morton, J. J., et al. (2007) Diastolic dysfunction in heart failure with preserved systolic function: need for objective evidence. J. Amer. Coll. Cardiol., 49, 687–694.

Prasad, A., Hastings, J. L., Shibata, S., Popovic, Z. B., Arbab-Zadeh, A., Bhella, P. S., et al (2010) Characterization of static and dynamic left ventricular diastolic function in patients with heart failure with a preserved ejection fraction. Circulation: Heart Failure, 3, 617–626. doi: 10.1161/CIRCHEARTFAILURE.109.867044.

Douglas, P. S., Garcia, M. J., Haines, D. E., Lai, W. W., Manning, W. J., Patel, A. R., et al. (2011) ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 Appropriate Use Criteria for Echocardiography. J. Amer. Soc. Echocardiogr, 24, 229–267. doi: 10.1016/j.echo.2010.12.008.

Gurevich, M. A. (2008) Khronicheskaya serdechnaya nedostatochnost' [Congestive heart failure]. Moscow: Prakticheskaya medicina. [in Russian].

Voronkov, L. H., Amosova, K. M., Bahrii, A. E., Dziak, H. V., Diadyk, O. I., Zharinov, O. Y., et al. (2011) Rekomendatsii asotsiatsii kardiolohiv Ukrainy z likuvannia khronichnoi sertsevoi nedostatnosti u doroslykh (perehliad 2011) [Ukraine Heart Association Guidelines for the treatment of chronic heart failure in adults (revision 2011)]. Sertseva nedostatnist, 1, 101–116. [in Ukrainian].

Voronkov, L. H., Amosova, K. M., Bahrii, A. E., Dziak, H. V., Diadyk, O. I., Zharinov, O. Y., et al (2012) Rekomendatsii z diahnostyky ta likuvannia khronichnoi sertsevoi nedostatnosti (2012) [Guidelines for the diagnosis and treatment of chronic heart failure (2012)]. Sertseva nedostatnist, 3, 60–96. [in Ukrainian].

Rosendorff, C. (Ed.) (2007) Osnovy kardiologii: Printsipy i praktika [Essential cardiology: principles and practice]. Lviv: Meditsina svіtu. [in Ukrainian].

Kovalev, V. N. (2008) Rukovodstvo po kardiologii [Manual Cardiology]. Kyiv: Morion. [in Ukrainian].

Diadyk, A. I., & Bagrii, A. E. (2009) Khronicheskaia serdechnaia nedostatochnost' v sovremennoi klinicheskoi praktike [Congestive heart failure in current clinical practice]. Lviv: Meditsina svitu. [in Ukrainian].

Parkhomenko, A. N., Irkin, O. I., Gavrilenko, T. I., Gurjeva, O. S., Ponomariova, G. V. (2005) Vzaimosviaz' urovnei provospalitel'nykh tsitokinov, S-reaktivnogo belka i razvitiia rannei postinfarktnoi dilatatsii polosti levogo zheludochka serdtsa [The interrelationship of proinflammatory cytokines, C-reactive protein and development of early left ventricular dilatation following myocardial infarction]. Ukrainskyi kardiolohichnyi zhurnal, 4, 39–43. [in Ukrainian].

Tselujko, V. I., Popova, E. I., Yakovleva, L. N. (2007) Osobennosti klinicheskogo techeniia ostrogo infarkta miokarda v zavisimosti ot stepeni ateroskleroticheskogo porazheniia venechnykh arterii [Features of clinical course of acute myocardial infarction depending on the degree of atherosclerosis of coronary arteries]. Ukrainskyi kardiolohichnyi zhurnal, 2, 50–53. [in Ukrainian].

Parkhomenko, О. М., Gurjeva, O. S., Bryl, Zh. V., Irkin, O. I., Shumakov, O. V., Kozhukhov, S. M., & Skarzhevskii, O. A. (2006) Prohnostychna rol markeriv systemnoho zapalennia u hospitalnyi period hostroho infarktu miokarda iz zubtsem Q [In-hospital prognostic valule of inflammatory response markers in patients with acute Q-wave myocardial infarction]. Ukrainskyi kardiolohichnyi zhurnal, 6, 19–24. [in Ukrainian].

Wiggers, H., Nielsen, S., Holdgaard, P., Flø, C., Nørrelund, H., Halbirk, M., et al. (2006) Adaptation of nonrevascularized human hibernating and chronically stunned myocardium to long-term chronic myocardial ischemia. Amer. J. Cardiol., 98(12), 1574–1581. doi: 10.1016/j.amjcard.2006.07.035.

Wilson, R., Chen, X., & Houser, S. R. (2007) Cellular and molecular abnormalities in failing cardiac myocytes. Congestive heart failure. J.D. Hosenpud, B.H. Greenberg (Eds.), (P. 15–29). Philadelphia: Lippincott, Williams & Wilkins.

Verheugt, F., Gersh, B. J., Armstrong, P. W. (2006) Aborted myocardial infarction: a new target for reperfusion therapy. Eur. Heart J., 27(8), 901–905.

Weber, K. T., Sun, Y., & Bhattacharya, S. K. (2007) Remodeling of the cardiac interstitium in heart failure. Congestive heart failure. J.D. Hosenpud, B.H. Greenberg (Eds.), (P. 147–166). Philadelphia: Lippincott, Williams & Wilkins.

Bagrij, A. E., Dyadyk, A. I., Shchukina, E. V., Lukashenko, L. V., Vorob'ev, A. S., Tsyba,| N. Yu. (2010) Antagonisty al'dosterona v lechenii bol'nykh s khronicheskoj serdechnoj nedostatochnost'yu i postinfarktnykh bol'nykh [Aldosterone antagonists in the treatment of patients with chronic heart failure and post-MI patients]. Serdechnaya nedostatochnost', 1, 32–43. [in Russian].

Kovalenko, V. M. (2012) Suchasni priorytety i rezultaty rozvytku kardiolohii v Ukraini [Current priorities and results of Cardiology in Ukraine]. Ukrainskyi kardiolohichnyi zhurnal, 1, 4–9. [in Ukrainian].

Kokorin, V. A., Sytnikov, N. V., Liusov, V. N., et al. (2009) Aktivnost' rennin-angiotenzin-al'dosteronovoi i simpatoadrenalovoi sistem v otdalennye sroki posle perenesenogo infarkta miokarda [The activity of the renin - angiotensin - aldosterone system and sympathoadrenal late after myocardial infarction]. Rossijskij kardiologicheskij zhurnal, 4, 17–22. [in Russian].

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How to Cite

1.
Syvolap VV, Lukashenko LV, Zhemanyuk SP, Gerasko MP, Franskyavichene LV. Features of aldosterone antagonists in the treatment of patients with acute myocardial infarction with ST elevation without chronic heart failure and post-MI chronic heart failure with low ejection fraction. Zaporozhye Medical Journal [Internet]. 2015Dec.29 [cited 2024Nov.23];17(6). Available from: http://zmj.zsmu.edu.ua/article/view/57363

Issue

No. 6 (2015): Zaporozhye medical journal

Section

Review

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