Efficacy of histological and cytological examination under different methods of sampling biopsies at endoscopy in patients with respiratory pathology

Authors

  • I. V. Liskina SO «National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National Academy of Medical Sciences of Ukraine»,
  • O. I. Shpak SO «National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National Academy of Medical Sciences of Ukraine»,
  • L. M. Zagaba SO «National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National Academy of Medical Sciences of Ukraine»,
  • V. B. Bychkovskiy SO «National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National Academy of Medical Sciences of Ukraine»,
  • M. F. Yatsina SO «National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National Academy of Medical Sciences of Ukraine»,

DOI:

https://doi.org/10.14739/2310-1210.2016.1.63872

Keywords:

Endoscopy, Biopsy, Cytological Techniques And Histological Techniques

Abstract

Aim. The article presents the value of different methods of sampling biopsy during endoscopy with cytological and morphological examination of biopsy material in the diagnostic algorithm of various pathological processes of the respiratory system.

Methods and results. The retrospective cohort study of 194 biopsy cases that were obtained during endoscopic studies with morphological study of biopsy material for 2011–2012 periods was presented in the article. The method of biopsy obtaining at endoscopy was determined by the nature and spread of the pathological process in the bronchi and/or lung tissue, which is specified directly in the course of bronchoscopy. In 31.44% of cases it was established that the most often diagnosis was «malignant lung neoplasm» in result of the endoscopy.

The parameters of sensitivity, diagnostic value and effectiveness of cytological and histological examinations were calculated. Cytological studies were characterized by high levels of sensitivity and diagnostic value in cases of diagnosis of malignant and benign tumors, non-specific inflammation of the bronchus and lung in cases of direct biopsy at fiberoptic bronchoscopy (FBS) (100.0%). For verification of the diagnosis of benign tumors, tuberculosis, sarcoidosis and «rare» diseases of the respiratory system the histological examination of the material from transbronchial lung biopsy (TBLB) was most important, the value of these indicators was 100.0%.

Conclusion. Effectiveness of the complex morphological study of biopsy material at direct biopsy at FBS was 80.5%, while TBLB – 73.6%. Overall effectiveness of complex cytological-histological examination of biopsies in endoscopic studies was 77.05%.

References

Karmazanovskij, G. G. (1997). Ocenka diagnosticheskoj znachimosti metoda («chuvstvitel'nost'», «specifichnost'», «obshhaja tochnost'») [Estimation of the Diagnostic Method Value ("Sensitivity”, "Specificity” and "General Accuracy”)]. Annaly hirurgicheskoj gepatologii, 2, 139–142. [in Russian].

Nakaz MOZ Ukrainy ”Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi) ta tretynnoi (vysokospetsializovanoi) medychnoi dopomohy. «Tuberkuloz»” vid 4 veresnia 2014 roku №620 [Order of the Ministry of Health of Ukraine ”Unified clinical protocol of primary, secondary (specialized) and tertiary (highly specialized) medical care. «Tuberculosis»”, September 4, 2014. №620]. [in Ukrainian].

Ovchinnikov, A. A. (2005). Metody e′ndobronkhial'noj diagnostiki pri zabolevaniyakh trakhei, bronkhov i lyogkikh [Methods of the endobronchial diagnostics at diseases of the trachea, bronchus and lung]. Prakticheskaya pul'monologiya, 2, 23. [in Russian].

Cheremisina, O. V., Pankova, O. V., Volkova, L. I., & Bogomyakov, V. S. (2005) Diagnosticheskaya fibrobronkhoskopiya pri vyyavlenii predopukholevoj patologii traheo-bronhial'nogo dereva [Diagnostic fiberoptic bronchoscopy in detecting preneoplastic pathology of tracheobronchial tree]. Palliativnaya medicina i reabilitaciya, 2, 50b–50. [in Russian].

Chernyaev, A. L. & Samsonova, M. V. (2011). Gistologicheskaya diagnostika zabolevanij legkikh [The histological diagnostics of lung diseases]. Prakticheskaya pul'monologiya, 1, 34–38. [in Russian].

Shtejner, M. L., Blashenceva, S. A., Zhestkov, A. V., Brylyaeva, E. V., Ustinov, M. S., & Protasov, A. D (2011). Nekotorye aspekty diagnostiki zabolevanij legkikh [Some diagnostic aspects of lung diseases]. Fundamental'nye issledovaniya, 9–1, 163–169. [in Russian].

Casoni, G. L. (2012). The role of transbronchial biopsy in the diagnosis of diffuse parenchymal lung diseases. Pro. Rev. Port. Pneumol, 18(2), 57–60.

Cavazza A., Rossi G., Carbonelli C., Spaggiari L., Paci M. & Roggeri A. (2010). The role of histology in idiopathic pulmonary fibrosis: an update. Respir. Med, 104(1), 11–22. doi: 10.1016/j.rmed.2010.03.013.

Bhat, G. Q., Mufti, S.A.T.S.K., Shah, S., Koul, P. A., Shah, P., Khan, A. H. & Jan, R. A. (2013). Correlative study of imprint and crush cytology with histopathology in endobronchial growths. J. Cytol. Histol, 4(3), 177–180.

Taheri, Z. M., Mohammadi, F., Karimi, S., Darjani, H. J., Seyfollahi, L., Emami, H., et al. (2007). Fiberoptic bronchoscopy: correlation of cytology and biopsy results. Tanaffos (Iran), 6(2), 46–50.

van der Heijden, E.,H., Casal, R. F., Trisolini, R., Steinfort, D. P., Hwangbo, B., Nakajima, T., et al. (2014). Guideline for the acquisition and preparation of conventional and еndobronchial ultrasound-guided transbronchial needle aspiration specimens for the diagnosis and molecular testing of patients with known or suspected lung cancer. Respiration, 88, 500–517. doi: 10.1159/000368857.

Hironori, U., Shigeo H., Yuka, B., Hisashi, T., Atsusji, M. Nasa, M., et al. (2012). Diagnostic efficacy of CT-guided transthoracic needle biopsy and fine needle aspiration in cases of pulmonary infectious disease. Med. Japanese J. Radiology, 30(7), 589–593. Doi: 10.1007/s11604-012-0094-3.

Leslie, K. O., Gruden, J. F., Parish, J. M. & Scholand, M. B. (2007). Transbronchial biopsy interpretation in the patient with diffuse parenchymal lung disease. Arch. Pathol. Lab. Med, 131, 407–423.

Cordeiro, C. R., Tomassetti, S., Romagnoli, M., Chilosi, M., Cancellieri, A., Gurioli, C. & Poletti, V. (2012). The role of transbronchial biopsy in the diagnosis of diffuse parenchymal lung diseases: Pro. Rev. Port. Pneumol, 18(2), 57–60.

Rooney, C. P., Wolf, K., & McLennan, G. (2002). Ultrathin bronchoscopy as an adjunct to standard bronchoscopy in the diagnosis of peripheral lung lesions. Respiration, 69, 63–68.

Wahyuni, T. D., Swidarmoko, B., Rogayah, R. & Hidayat, H. (2011). The positive result of cytology brushing at flexible fiberoptic bronchoscopy compared with transthoracic needle aspiration in central lung tumor. J. Respir. Indonesia, 31(1), 22–31.

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1.
Liskina IV, Shpak OI, Zagaba LM, Bychkovskiy VB, Yatsina MF. Efficacy of histological and cytological examination under different methods of sampling biopsies at endoscopy in patients with respiratory pathology. Zaporozhye Medical Journal [Internet]. 2016Mar.25 [cited 2024Nov.22];18(1). Available from: http://zmj.zsmu.edu.ua/article/view/63872

Issue

No. 1 (2016): Zaporozhye medical journal

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Original research

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