Spectrophotometric determination of original active pharmaceutical ingredient Quinabut and tablets based on it
DOI:
https://doi.org/10.14739/2310-1210.2016.1.64166Keywords:
Sodium 4-(3-methyl-2-оxo-2H-[1, 2, 4]triazino[2, 3-c]quinazolin-6-yl)butanoate, Quinabute, Substance, Tablets, Analysis, SpectrophotometryAbstract
Aim. The sensitive, efficient and express method for original active pharmaceutical ingredient Quinabut determination and based on it tablets was described in presented article.
Methods and results. Detailed analysis of physicochemical properties of studied compound conducted by authors allowed to substantiate the usage of purified water as solvent. It was shown, that UV-spectra of active pharmaceutical ingredient was characterized by absorption maximum at 232 nm. Length wave mentioned above was used for further studies. The elaborated method is based on evaluation of proper absorption of active pharmaceutical ingredient solution, data of absorption of studied sample and standard solution was used for calculation of the final results.
Conclusions. Correctness and suitableness of proposed method for realization of planned tasks were proven by conduction of standardized validation procedure. The evaluation of linearity was conducted in range of concentration wherein the compliance with Beer law was observed. Indexes of linear dependence, that were obtained according to SPhU recommendations (correlation coefficient r, residual sum of deviation squares, free term of linear regression) were in compliance with requirements for linear dependence parameters. Conducted evaluation of precision and accuracy of method showed it compliance with requirements of SPhU. The prediction of total irreproducibility was conducted for confirmation of method correctness by repeating in other laboratories. It was shown that proposed method would produce correct results in other laboratories.
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