Spectrophotometric determination of original active pharmaceutical ingredient Quinabut and tablets based on it
DOI:
https://doi.org/10.14739/2310-1210.2016.1.64166Keywords:
Sodium 4-(3-methyl-2-оxo-2H-[1, 2, 4]triazino[2, 3-c]quinazolin-6-yl)butanoate, Quinabute, Substance, Tablets, Analysis, SpectrophotometryAbstract
Aim. The sensitive, efficient and express method for original active pharmaceutical ingredient Quinabut determination and based on it tablets was described in presented article.
Methods and results. Detailed analysis of physicochemical properties of studied compound conducted by authors allowed to substantiate the usage of purified water as solvent. It was shown, that UV-spectra of active pharmaceutical ingredient was characterized by absorption maximum at 232 nm. Length wave mentioned above was used for further studies. The elaborated method is based on evaluation of proper absorption of active pharmaceutical ingredient solution, data of absorption of studied sample and standard solution was used for calculation of the final results.
Conclusions. Correctness and suitableness of proposed method for realization of planned tasks were proven by conduction of standardized validation procedure. The evaluation of linearity was conducted in range of concentration wherein the compliance with Beer law was observed. Indexes of linear dependence, that were obtained according to SPhU recommendations (correlation coefficient r, residual sum of deviation squares, free term of linear regression) were in compliance with requirements for linear dependence parameters. Conducted evaluation of precision and accuracy of method showed it compliance with requirements of SPhU. The prediction of total irreproducibility was conducted for confirmation of method correctness by repeating in other laboratories. It was shown that proposed method would produce correct results in other laboratories.
References
Kovalenko, S. І., Stepaniuk, H. І., Scoryna, D. Yu., Voskoboinik, O. Yu., Shelest, О. H., Berest, H. H., et al. (patentee) (2012) Patent Ukrainy na vynakhid №97586 MPK (2009) S07D 253/00 (2006/01), C07D 253/10 (2006/01). (3-R-8-R1-9-R2-10-R3-11-R4-2-oxo-2N-[1,2,4]-triazyno[2,3-s]khinazolin-6-il)alkilkarbonovi kysloty [Patent of Ukraine for invention №97586 МПК (2009) С07D 253/00 (2006/01), C07D 253/10 (2006/01). (3-R-8-R1-9-R2-10-R3-11-R4-2-oxo-2Н-[1,2,4]triazino[2,3-с]khinazolin-6-il)alkilkarbonovie kisloty [(3-R-8-R1-9-R2-10-R3-11-R4-2-oxo-2Н-[1,2,4]triazino[2,3-с]quinazoline-6-yl)alkylcarboxylic acids]]. Bulleten, 4. [in Ukrainian].
Stepaniuk, H. І., Pochelova, О. V., Chornoivan, N. І., Voskoboinik, О. Yu., Skoryna, D. Yu., & Kovalenko, S. І. (patentee) (2013) Patent Ukrainy na korysnu model №81634 MPK (2013.01) A61K 31/00. Soli (3-R-8-R1-9-R2-10-R3-11-R4-2-okso-2N-[1,2,4]triazyno[2,3-s]khinazolin-6-il)alkilkarbonovykh kyslot, shcho pidvyshchuiut fizychnu vytryvalist orhanizmu [Patent of Ukraine for useful model № 81634 МПК (2013.01) А61К 31/00. Soli (3-R-8-R1-9-R2-10-R3-11-R4-2-okso-2Н-[1,2,4]triazino[2,3-с]khinazolin-6-il)alkilkarbonovyh kislot, shcho pidvyshchuyut fizychnu vytryvalist organizmu. [Salts of (3-R-8-R1-9-R2-10-R3-11-R4-2-oxo-2Н-[1,2,4]triazino[2,3-с]quinazolin-6-yl)alkylcarboxylic acids that increases, physical endurance of organism]]. Bulleten, 13. [in Ukrainian].
Semenenko, N. O., Stepaniuk, H. І., Semenenko, А. І., Kovalenko, S. І., Voskoboinik, О. Yu., & Skorina, D. Yu. (patentee) (2013) Patent Ukrainy na korysnu model №84257 MPK (2013.01) A61K 31/215. Zastosuvannia natriievoi soli 4-(2-okso-3-metyl-2N-[1,2,4]triazyno[2,3-s]-khinazolin-6-il)butanovoi kysloty v yakosti tserebroprotektornoho zasobu [Patent of Ukraine for useful model №84257 МПК (2013.01) А61К 31/215. Zastosuvanya natrievoy soli 4-(2-оксо-3-metil-2Н-[1,2,4]triazino[2,3-с]khinazolin-6-il)butanovoy kisloti v yakosti tserebroorotektornogo zasobu [Application of sodium salt of 4-(2-oxo-3-methyl-2Н-[1,2,4]triazino[2,3-с]quinazolin-6-yl)butanoic acid as cerebroprotective remedy. № U201306088]. Bulleten, 19, 4. [in Ukrainian].
Stepaniuk, H. І., Chornoivan, N. H., Kovalenko, S. I., Shelest, О. H., Skoryna, D. Yu., Tsimbaliuk, V. V., et al/ (2011) Skryninh analhetychnoi aktyvnosti v riadu pokhidnykh (3-R-2-okso-2N-[1,2,4]tryazyno[2,3-s]khinazolin-6-il)karbonovykh kyslot [Screening of actoprotective activity among (3-R-2oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)carboxylic acids]. Farmakolohіia ta lіkarska toksykolohіia, 1(20), 52–55. [in Ukrainian].
Stepaniuk, H. I., Semenenko, N. O., Kovalenko, S. I., Skoryna, D. Yu., & Semenenko, S. I. (2011) Otsinka tserebroprotektornoi dii pokhidnykh (3-R-2-okso-2N-[1,2,4]-tryazyno[2,3-s]khinazolin-6-il)karbonovykh kyslot na modeli hostroho porushennia mozkovoho krovoobihu v shchuriv [Evaluation of cerebroprotective activity of (3-R-2-oxo-2Н-[1,2,4]triazino[2,3-с]quinazolin-6-yl)carboxylic acids on acute disturbed cerebral circulation model on mice]. Farmakolohіia ta lіkarska toksykolohіia, 6(25), 22–26. [in Ukrainian].
Semenenko, N. О., Stepaniuk, H. І., Marchuk, О. V., Semenenko, А. І., Voskoboinik, O. Yu., & Kovalenko, S. I. (2103) Vplyv natriievoi soli 4-(2-okso-3-metyl-2N-[1,2,4]triazyno[2,3-s]khinazolin-6il)butanovoi kysloty (spoluky DSK¬38) na vuhlevodno-enerhetychnyi obmin u mozku shchuriv za umov hostroho porushennia mozkovoho krovoobihu [Effect of sodium salt of 4-(2-oxo-3-methyl-2Н-[1,2,4]triazino[2,3-с]quinazolin-6-yl)butanoic acid (compound DSK-38) on carbohydrate and energy metabolism of rats on acute disturbed cerebral circulation model]. Farmakolohіia ta lіkarska toksykolohіia, 3(34), 28–34. [in Ukrainian].
Saienko, А. V., Stepaniuk, H. І., & Kovalenko, S. І. (2014) Porivnialna otsinka kursovoho vvedennia natriievoi soli 3-(2-okso-3-fenil-2H-[1,2,4]triazyno[2,3-c]khinazolin-6-il)propanovoi kysloty ta bemitylu na povedinkovo-poshukovi reaktsii shchuriv v umovakh tryvaloi hipokinezii [Comparative evaluation of course administration of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)propanoic acid and bemethyl on behavior and search reactions of rats in long hypokinesia condition]. Ukrainskyi medychnyi almanakh, 2(17), 138–142. [in Ukrainian].
(2008) Derzhavna farmacopeia Ukrainy [State pharmacopeia of Ukraine], (Sup. 2). Kharkiv: Naukovo-ekspertnyi farmakopeinyi tsentr. [in Ukrainian].
(2004) Derzhavna farmacopeia Ukrainy [State pharmacopeia of Ukraine], (Sup. 1). Kharkiv: RIREG. [in Ukrainian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
