The Functional Competence State of Patients with Rheumatic Arthritis and Different Variants of Polymorphic Site of 5-HTR2A T102C Gene or A-1438-G Depending on Sex

Authors

  • L. O. Protsiuk Vinnytsya National Pirogov Memorial Medical University,

DOI:

https://doi.org/10.14739/2310-1210.2016.2.69231

Keywords:

Rheumatoid Arthritis, Polymorphism Genetic, Genotype

Abstract

The state of functional competence in 100 patients with RA and different variants of polymorphic sites of serotonin receptor 5-HT2A T102C or A-1438-G gene was studied using the Health Assessment Questionnaire (HAQ). Polymorphic sites of T102C or A-1438-G gene were amplified with polymerase chain reaction. Anxiety level was assessed by Spielberger State-Trait Anxiety Scale (STAI). Depressive status and depression severity were evaluated by Hamilton Depression Rating Scale (HDRS).

Results. In the study, we found that women with RA and TT and TC genotypes had significantly more frequent symptoms of fatigue, autonomic anxiety and depressive disorders (DS), high state, trait anxiety and symptoms of severe depression (p <0.001). Whereas women with CC genotype significantly more (p <0.05) often had mild symptoms of DS than women with GG genotype as compared with АG genotype women. According to HAQ findings women with TC, TT and GG genotype had decreased ability to perform minimal household physical activity as compared to male patients.

Conclusions. Functional competence values proved to be considerably worse in female patients with TC and GG genotypes than in males. There was a tendency of more severe disorders in women with TT and AA genotypes. Positive relationship between HAQ index and anxiety depressive disorders in female patients with TC, CC, AA and GG genotypes were found while in patients with TT genotype this relationship was inverse.

References

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1.
Protsiuk LO. The Functional Competence State of Patients with Rheumatic Arthritis and Different Variants of Polymorphic Site of 5-HTR2A T102C Gene or A-1438-G Depending on Sex. Zaporozhye Medical Journal [Internet]. 2016May23 [cited 2024Nov.23];18(2). Available from: http://zmj.zsmu.edu.ua/article/view/69231

Issue

No. 2 (2016): Zaporozhye medical journal

Section

Original research

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