Relations Gln27Glu polymorphism β2-adrenoceptor gene with bronchial asthma
DOI:
https://doi.org/10.14739/2310-1210.2016.2.69328Keywords:
Bronchial Asthma, Genetic Polymorphism, Receptors-AdrenergicAbstract
Purpose – to analyze scientific literature data on the link between Gln27Glu polymorphism gene of β2-adrenergic receptors development and bronchial asthma (BA) severity, level of control.
Results. This article analyzes the literature on risk, severity and level of asthma control based on genetic characteristics of patients. Numerical studies have shown that gene Gln27Glu polymorphism ADBR2 affect the development and severity of asthma control level that allows to modify the treatment strategy.
According to data of WHO approximately 300 million people suffer from asthma around the world. BA – is a polygenic disease with complex inheritance type. There are two basic approaches to the study of candidate genes that provoke multifactorial disease: use of candidate genes (method of candidate mapping) and "genome scan" or "positional cloning". Full henome search of gene predisposition to asthma is the most effective. At present it is known that there are more than 100 genes predisposition to asthma. β2-adrenergic receptors (ADRB2) play an important role in the regulation of contractile elements in the airway wall, because mutations of the gene encoding it, involved in the development of asthma. ADRB2 gene was cloned for the first time in 1987 by Kobilka V. K. et al. ADRB2 gene does not contain introns nor in coding part, neither in untranslated sequences, so it can be attributed to a single superfamily of receptors coupled with G-proteins. Marsh D.G. et al. (1994) and Meyers D.A. et al. (1999) reported about the clutch 5q chromosome areas with BA for the first time (the credible association chromosome 5q31 area with bronchial hyperreactivity (BHR). The most common and studied polymorphism is polymorphism with of amino acid substitutions Gln27Glu, which causes a decrease in the number of receptors on the surface of the bronchi cells after interaction with β2-agonists and promotes BHR.
Conclusions. Analysis of Gln27Glu polymorphism gene Gln27Glu ADRB2 connection at risk and severity of BA showed mixed results, which can be explained by the existence of the possible for each population specific set of candidate genes.
Research on Gln27Glu polymorphism gene ADRB2 association with risk of development, severity and efficiency of basic treatment BA has not been conducted in Ukraine. Further researches of this problem in Ukraine are needed.
References
Asanov, A. Y., Namazova, L.S., & Zhurkova, N.V. The genetic basis of the etiopathogenesis of bronchial asthma. Sib. Med. J. 2010;3(3):82-85.
Mironov, J. A, Trofimov, V. I., & Dubin, M. V. (2006). Pharmacogenetic aspects steroidorezistentnosti in patients with severe asthma [Proceedings XVI National Congress on Respiratory Disease].pр. 23-30.
Psakhe, I. V.Problemu nasledstvennosti pri boleznyah lehkih. K.Med.J. 2009: 350
Fedorova, Yu. Yu. Issledovanie associatsii polimorphuch variantov gena β2-adrenoreceptora s bronchialnoyu astmoy. Practic medicine. 2013;5:18-25
Haitova, N. M. Genetically caused forms of chronic nonspecific pulmonary diseases [On the study of the prognostic value of biological markers of hereditary predisposition in patients with bronchial asthma]. Kiev, 2006, pp. 57-61.
Birbian, N., Singh, J, & Jindal, S. Association of β(2)-adrenergic receptor polymorphisms with asthma in a North Indian population. Lung. Epub.2012;190:497-504.
Chiang, C. H., Lin, M. W., & Yang, U. C. Association of β(2)-adrenergic receptor polymorphisms with asthma J. Chin. Med. Assoc. 2012; 75:635-643.
Contopoulos-Ioannidis, D.G., Manoli, E.N., & Ioannidis, J.P. Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immunol. 2005;115:963- 972.
D'Amato, M.I., Vitiani, L.R. & Petrelli, G.A. Association of persistent bronchial hyperresponsiveness with b2-adrenoceptor haplotypes.J. Respir. Crit. Med. 1998;158: 1968-1973.
Hizawa, N. Beta-2 adrenergic receptor genetic polymorphisms and asthma. J.Clin. Pharm. Ther. 2009; 34: 631-643.
Hizawa, N. Pharmacogenetics of β2-agonists .J. Allergol. Int. 2011;60:239-246.
Hopes, E., McDougall, C. & Christie, G. Association of glutamine 27 polymorphism of β2-adrenoceptor with reported childhood asthma: population based study. BMJ 1998; 316: 664-674.
Isaza, C., Sepúlveda-Arias J.C., Agudelo, B.I. β2-adrenoreceptor polymorphisms in asthmatic and non-asthmatic schoolchildren from Colombia and relationship to treatment response. J. Pediatr.Pulmonol. 2012: 53-57.
Zhang, J.Q., Wang, L., Shu, J.K., Wang, X.M., Dai, L.M. Relationship between polymorphisms in the 5' leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China. Respirology. 2011; 16: 1221-1227.
Kim, S.-H, Oh, H.-B, Lee, K.-W., Shin, E.-S., Kim, C.-W., Hong, C.-S., Nahm, D.-H., Park. H.-S. HLA DPP1 15-DPB1 05 haplotype: a susceptible gene marker for isocyanate induced occupational asthma . J. Allergy. 2006;. 61: 891-894.
Liang, S.Q., Chen, X.L., Deng, J.M. Beta-2 adrenergic receptor (ADRB2) gene polymorphisms and the risk of asthma: a meta-analysis of case-control studies. PLoS One. 2014; 11: 104-108.
Limsuwan, T., Thakkinstian, A., Verasertniyom, J. Possible protective effects of the Glu27 allele of beta2-adrenergic receptor polymorphism in asthmatic patients. J. Aller. Immunol. 2010; 28: 107-114.
Litonjua, A.A., Lasky-Su, Schneiter, K., Tantisira, K.G. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. J. Respir. Crit. Care Med. 2008; 178: 688-694.
Marson, F.A., Ribeiro, J.D., Bertuzzo, C.S. Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors. Asthma Clin. Immunology. 2014; 53: 320-323.
Martinez , F.D., Graves P.E., Baldini, M. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing . J Clin. Invest. 2007; 100: 3184-3188.
Petrovic-Stanojevic, N., Topic, A., Nikolic, A. Polymorphisms of beta2-adrenergic receptor gene in serbian asthmatic adults: effects on response to β2-agonists. Mol. Diagn.Ther. 2014; 18: 639-646.
Portelly, M., Sayers, I. Genetic basis for personalized medicine in asthma. Expert. Rev. Respir. Med. 2012; 16: 223- 236.
Santillan, A.A., Camargo, C.A., Ramires-Rivera, A.A. Association between b2-adrenoreceptor polymorphism and asthma diagnosis among Mexican adults. J. Clin. Immunol. 2003; 112: 1095-1100.
Woszczek, G., Borowiec,M., Ptasinska, A. β2-ADВR haplotypes/polymorphisms associate with bronchodilator response and total IgE in grass allergy. J. Allergy. 2005; 60: 1412-1417.
Zhong, L., Liu, L., Wang, M. Relationship between polymorphisms in the 5 leader cistron, positions 16 and 27 of the adrenergic β2 receptor gene and asthma in a Han population from southwest China . J. Respirology . 2011; 150: 150-153.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
