Violations of coagulation hemostasis in patients with arterial hypertension in combination with osteoarthrosis

Authors

  • V. V. Rodionova Dnipropetrovsk Medical Academy of the Health Ministry of Ukraine,
  • O. S. Khmel' Dnipropetrovsk Medical Academy of the Health Ministry of Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2016.3.76919

Keywords:

Arterial Hypertension, Osteoarthrosis, Coagulation hemostasis

Abstract

Objective: To define violations of coagulation hemostasis in patients with arterial hypertension (HT) and osteoarthrosis (OA).

Materials and Methods: The study involved 70 people. The main group included 25 patients (age 40-65 years) with hypertension stage II, combined with knee OA stage 2 according to Kellgren-Lawrence. The first comparison group consisted of 15 patients with hypertension stage II, the second comparison group consisted of 15 patients with OA stage 2, the control group - 15 almost healthy people.

Results and Discussion: In patients with OA dominated violation of coagulation hemostasis. In patients with hypertension and hypertensive OA was observed violation of platelet hemostasis in combination with coagulation disorders.

Indicators of aPTT, activated recalcification time, prothrombin ratio and INR were significantly lower in patients of all studied groups in comparison with the control group. At the same time there were significantly increased rates: SFMC, autoсoagulation test and XII-dependent lysis.

Conclusion: hypercoagulation disorders with normal platelet function prevailed in patients with OA. Patients with HT and HT in combination with OA had hypercoagulation with increased platelet function, which may contribute to the risk of thrombus formation.

References

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How to Cite

1.
Rodionova VV, Khmel’ OS. Violations of coagulation hemostasis in patients with arterial hypertension in combination with osteoarthrosis. Zaporozhye Medical Journal [Internet]. 2016Sep.6 [cited 2024Jun.18];18(3). Available from: http://zmj.zsmu.edu.ua/article/view/76919

Issue

Section

Original research