Excessive body mass and obesity as a cause of progression of endogenous intoxication in patients with non-alcoholic fatty liver disease
DOI:
https://doi.org/10.14739/2310-1210.2016.3.76985Keywords:
Overweight, Obesity, Body Mass Index, Endotoxemia, Fatty LiverAbstract
Aim – to study the features of indicators of endogenous intoxication (EI), depending on the body mass index (BMI) in patients with excessive body mass (EBM) and obesity (OB) in combination with nonalcoholic hepatic steatosis (NAHS) and nonalcoholic steatohepatitis (NASH).
Materials and methods. The study involved 200 patients with OB in conjunction with non-alcoholic fatty liver disease and BT pathology, who at the time of sonographic and morphological study of liver biopsy revealed signs of hepatic steatosis. Depending on the degree of increase in BMI of all patients with OB and NAHS (n=100) and NASH (n=100) were divided into three groups: 1 group – EBM; 2 group – OB I degree; 3 group – OB II degree. The control group consisted of 20 practically healthy persons (PHP). Indicators of EI were determined by the content of middle weight molecules (MWM), their fractional composition: MWM-λ-210, MWM-λ-254, MWM-λ-280, concentration of copper (Cu) in serum of blood.
Results. The content of MWM, MWM-λ-210, MWM-λ-254, MWM-λ-280, and Cu in the serum of patients with the EBM and OB in combination with NAHS and NASH were significantly increased relative to PHP in the presence of EBM and OB I degree (from p<0.05 to p<0.001), with higher values of EI indicators in patients with OB II degree.
Conclusion: Rises in the level of EI in patients with the OB in combination with a NAHS and NASH and pathology BT have expressed significant dependence on the increase of the BMI parameters.
References
Dralova, O. V. (2012). Vozmozhnosti korrekcii massy tela: pol'za i riski [Possibilities of correction of body weight: benefits and risks]. Consilium Medicum, 12, 63–67. [in Russian].
Harbour, R., Lowe, G., & Twaddle, S. (2011). Scottish Intercollegiate Guidelines Network: the first 15 years (1993-2008). J R Coll Physicians Edinb, 41(2), 163–168. doi: 10.4997/JRCPE.2011.209.
Drapkina, O. M., & Popova, Y. R. (2013). Rol' ozhireniya v razvitii arterial’noj gipertenzii i nealkogol’noj zhirovoj bolezni pecheni [The role of obesity in the development of hypertension and non-alcoholic fatty liver disease]. Ukraiinskyj medychnyj chasopys, 2, 125–128. [in Ukrainian].
Toouli, J., Fried, M., & Ghafoor, K. A. (2009). Obesity World Gastroenterology Organisation Global Guideline.
Nakaz Ministerstva okhorony zdorovia Ukrainy «Pro zatverdzhennia protokoliv nadannia medychnoi dopomohy khvorym za spetsialnistiu Hastroenterolohiia» vid 13.06.2005 roku. №271. [On approval of protocols of medical care to patients in the specialty of Gastroenterology from June, 13, 2005 year] [in Ukrainian].
Nakaz Ministerstva okhorony zdorovia Ukrainy Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi) medychnoi dopomohy «Nealkoholnyi steatohepatyt» vid 06.08.2014 r. № 826 [Unified clinical protocol of primary, secondary (specialized) medical care Nonalcoholic steatohepatitis from August, 6, 2014 year] [in Ukrainian].
Nikolajchuk, V. V., Moin, V. M., & Kirkovskij, V. V. (1991) Sposob opredeleniya «srednikh molekul» [Method of the definition of «middle molecules»]. Laboratornoe delo, 10, 13–16. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
