Chemotherapy and quality of life among patients with multiple myeloma: a 3-year prospective study


  • B. B. Samura Zaporizhzhia State Medical University, HZaporizhzhia Regional Clinical Hospital,



Quality Of Life, Multiple Myeloma, Survival, Prognosis


Aim. Little is known about change in quality of life among multiple myeloma survivors. We examined quality of life to assess demographic, psychosocial, and clinical risk factors for poor outcomes depending on appearance of cardiovascular events among long-term survivors of multiple myeloma.

Methods: Surveys were given to multiple myeloma survivors on average who participated in the study after reaching regression and were monitored during 3 years. 116 patients were invited to complete the 36-item Short Form Health Survey (SF-36) and the Quality of Life-Cancer Survivors questionnaire (QOL-CS), and 107 patients (92.4%) responded. Standardized measures of quality of life, perceptions of the impact of myeloma, symptoms, and demographic variables were examined using linear regression modeling to identify predictors of quality of life over time.

Results: During observation period progression of multiple myeloma was proved in 41 patients, 6 persons were excluded for poor follow-up. One hundred ninety three cumulative clinical events occurred in 37 patients (53.6%) within the follow-up, with their distribution being as follows:14 cardiovascular deaths, 90 cardiac arrhythmias, 13 cardiac ischemic events, 6 strokes, 21 chronic heart failures and 49 hospital admissions for cardiovascular reasons. 28 deaths were not related with cardiovascular pathology. Patients who had cardiovascular events reported significantly worse psychological well-being, general health, less vitality and health-related quality of life than patients without cardiovascular events. Chemotherapy was associated with quality of life outcomes. Patients who were not diagnosed cardiovascular events reported better social well-being than patients who were diagnosed cardiovascular events.

Conclusion: The general health perceptions and vitality levels of multiple myeloma survivors depend on passed courses of chemotherapy, appearance of cardiovascular events during 3 years.


Der-Martirosian, C., Kritz-Silverstein, D., & Barrett-Connor, E. (2010) Five-year stability in associations of health-related quality of life measures in community-dwelling older adults: The Rancho Bernardo Study. Qual. Life Res., 19(9), 1333–1341. doi: 10.1007/s11136-010-9700-y.

Ganz, P. A., Desmond, K. A., Leedham, B., Rowland, J. H., Meyerowitz, B. E., & Belin, T. R. (2002) Quality of life in long-term, disease-free survivors of breast cancer: A follow-up study. J. Natl. Cancer Inst., 94(1), 39–49.

Norman, G. R., Sloan, J. A., & Wyrwich, K. W. (2003). Interpretation of changes in health-related quality of life: The remarkable universality of half a standard deviation. Med. Care., 41(5), 582–592.

Osborne, T. R., Ramsenthaler, C., de Wolf-Linder, S., Schey, S. A., Siegert, R. J., Edmonds, P. M., & Higginson, I. J. (2014) Understanding what matters most to people with multiple myeloma: a qualitative study of views on quality of life. BMC Cancer., 14(1), 496. doi: 10.1186/1471-2407-14-496.

Osborne, T. R., Ramsenthaler, C., Siegert, R. J., Edmonds, P. M., Schey, S. A., & Higginson, I. J. (2012). What issues matter most to people with multiple myeloma and how well are we measuring them? A systematic review of quality of life tools. Eur. J. Haematol., 89(6), 437–457. doi: 10.1111/ejh.12012.

Reeve, B. B., Potosky, A. L., Smith, A. W., Han, P. K., Hays, R. D., Davis, W. W., et al. (2009) Impact of cancer on health-related quality of life of older Americans. J. Natl. Cancer Inst., 101(12), 860–868. doi: 10.1093/jnci/djp123.

Sangha, O., Stucki, G., Liang, M. H., Fossel, A. H., & Katz, J. N. (2003). The Self-Administered Comorbidity Questionnaire: A new method to assess comorbidity for clinical and health services research. Arthritis Rheum., 49(2), 156–163. doi: 10.1002/art.10993.

Sonneveld, P., Verelst, S. G., Lewis, P., Gray-Schopfer, V., Hutchings, A., Nixon, A., & Petrucci, M. T. (2013). Review of health-related quality of life data in multiple myeloma patients treated with novel agents. Leukemia, 27(10),1959–1969. doi: 10.1038/leu.2013.185.

Ware, J. E., & Kosinski, M. A. (2004) SF-36 Physical and Mental Health Summary Scales: A Manual for Users of Version. Lincoln, RI: Quality Metric.

How to Cite

Samura BB. Chemotherapy and quality of life among patients with multiple myeloma: a 3-year prospective study. Zaporozhye medical journal [Internet]. 2016Oct.13 [cited 2024Feb.27];18(4). Available from:



Original research