The level of neuron-specific enolase and S-100 protein in the cerebrospinal fluid of patients with acute bacterial meningitis


  • A. V. Sokhan Kharkiv National Medical University,



Bacterial Meningitis, Neuron-Specific Enolase, S-100 Protein, Cerebrospinal Fluid


Aim. To evaluate the diagnostic and prognostic role of neuron-specific enolase (NSE) and S-100 protein levels in cerebrospinal fluid (CSF) of patients with acute bacterial meningitis in the course of the disease.

Materials and Methods. 54 cases of acute bacterial meningitis were analyzed, among them – 26 with pneumococcal and 28 with meningococcal etiology. Patients were divided into groups depending on the severity and etiology of disease. In addition to routine laboratory methods, we analyzed the CSF levels of S-100 protein and NSE at admission and after 10 – 12 days of treatment. 12 patients with acute respiratory infections and meningism were examined as a comparison group.

Results. In all patients with acute bacterial meningitis CSF NSE and protein S-100 levels were significantly higher than in the control group (P <0,05). CSF neuro specific proteins level was in direct dependence on severity of the disease, and in patients with severe disease was significantly higher than in patients with moderate severity and in the control group (P <0,01). After 10 – 12 days of treatment, the level of the NSE and S-100 protein decreased, but in severe cases was still higher than in the control group (P <0,05).

Conclusions. Increased cerebrospinal fluid NSE and S – 100 protein levels shows the presence and value of neurons and glial cells damage in patients with acute bacterial meningitis. CSF S-100 protein and neuron-specific enolase levels help to determine the severity of neurons destruction and glial cells in patients with acute bacterial meningitis. Level of neurospecific protein is in direct proportion to the severity of the disease and is the highest in patients with severe cases (P<0,05). It confirms the diagnostic and prognostic value of CSF neurospecific protein determination in patients with bacterial meningitis.


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How to Cite

Sokhan AV. The level of neuron-specific enolase and S-100 protein in the cerebrospinal fluid of patients with acute bacterial meningitis. Zaporozhye Medical Journal [Internet]. 2016Oct.13 [cited 2024Jun.18];18(4). Available from:



Original research