Abdominal obesity as the colorectal adenomas risk factor


  • K. N. Mylytsya Zaporizhzhіa Medical Academy of Post-Graduate Education Ministry of Health of Ukraine,
  • O. I. Maslov Zaporizhzhіa Medical Academy of Post-Graduate Education Ministry of Health of Ukraine,




Colonoscopy, Polyps Colon, Obesity, BMI


Obesity is a risk factor for many diseases, including colorectal cancer. Aim: to study association of the constitutional features (height, weight, waist circumference) with detection of colon polyps on the screening colonoscopy.

Materials and methods: Constitutional features (height, weight, waist circumference) of 145 patients were assessed with detection of colon polyps on the screening colonoscopy for the period from 2013to 2015. Exclusion criteria were:  cancer of any location in history, surgery within the past two years, the inflammatory bowel diseases (Crohn's disease, ulcerative colitis), autoimmune diseases (rheumatoid arthritis, HIV, AIDS, SLE), diabetes, chronic liver or kidney disease, family polyposis.

Results: the presence of adenomas (OR = 6.0 CI: 2,2-16,7); multiplicity of polyps (the possibility that there will be ≥ 3 polyps was 6.4, CI: 1,4-29,9) were significantly higher in obese patients than in those with normal weight. Subjects with a waist circumference in the highest tertile (>115 cm), were 4.6 times more likely to identify ≥ 3 polyps than those with waist circumference in the lowest tertile (<96 cm) . The probability of detection of adenomas in patients with a waist circumference in the highest tertile were 6.2 times higher than in the lowest tertile.

Conclusions. Visceral obesity is associated with a morphological type and number of colon polyps. The presence of visceral obesity significantly increases the risk of colon adenomas. Increased visceral fat layer is an indication for colonoscopy especially of the right half of the colon examination. Screening colonoscopy should be recommended for the obese patients after 50 y.o. in order to diagnose adenomas of the colon and colorectal cancer.


Veselov, V. V., Fedorov, E. D., Samadov, B. Kh., et al. (2014) Principi organizacii i kriterii kachestva kolonoskopii vypolnyaemoj s cel’yu skrininga kolorektal´nnogo raka [Principles of organization and quality criteria for colonoscopy performed to screen for colorectal cancer]. Proe´kt rekomendacii rossijskogo e´ndoskopicheskogo obschestva dlya vrachej e´ndoskopistov, gastroe´nterologov, terapevtov, onkologov, khirurgov, 33. Moscow. [in Russian].

Nikishaev, V. I., Patij, A. R., Tumak, I. N., & Kolyada, I. A. (2012) E´ndoskopicheskaya diagnostika rannego kolorektal´nogo raka [Endoscopic diagnosis of early colorectal cancer]. Ukrainskyi zhurnal maloinvazyvnoi ta endoskopichnoi khirurhii, 16(1), 35–55.

Balistreri, C. R., Caruso, C., & Candore, G. (2010) The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm, 2010, 802078. doi: 10.1155/2010/802078.

Ben, Q., An, W., Jiang, Y., Zhan, X., Du, Y., Cai, Q.C., et al. (2012) Body mass index increases risk for colorectal adenomas based on meta-analysis. Gastroenterology, 142, 762–772. doi: 10.1053/j.gastro.2011.12.050.

Coussens, L. M., Zitvogel, L., & Palucka, A. K. (2013) Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science, 339, 286–291. doi: 10.1126/science.1232227.

Flegal, K. M., Carroll, M. D., Kit, B. K., & Ogden, C. L. (2012) Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA, 307, 491–497. doi: 10.1001/jama.2012.39.

Harriss, D. J., Atkinson, G., George, K., Cable, N. T., Reilly, T., Haboubi, N., et al. (2009) Lifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index. Colorectal Dis, 11, 547–563. doi: 10.1111/j.1463-1318.2009.01766.x.

Hedley, A. A., Ogden, C. L., Johnson, C. L., Carroll, M. D., Curtin, L. R., Flegal, K. M. (2004) Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA, 291, 2847–2850. doi:10.1001/jama.291.23.2847.

Larsson, S. C., & Wolk, A (2007) Obesity and colon and rectal cancer risk: a metaanalysis of prospective studies. Am J Clin Nutr, 86, 556–565.

Lyon, C. J., Law, R. E., & Hsueh, W. A. (2003) Minireview: adiposity, inflammation, and atherogenesis. Endocrinology, 144, 2195–2200.

Ma, Y., Yang, Y., Wang, F., Zhang, P., Shi, C., Zou, Y., & Qin, H. (2013) Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One, 8, e53916. doi: 10.1371/journal.pone.0053916.

Moghaddam, A. A., Woodward, M., & Huxley, R. (2007) Obesity and risk of colorectal cancer: A meta-analysis of 31 studies with 70,000 events. Cancer Epidemiology Biomarkers & Prevention,16, 2533–2547.

Okabayashi, K., Ashrafian, H., Hasegawa, H., Yoo, J. H., Patel, V. M., Harling, L., et al. (2012) Body mass index category as a risk factor for colorectal adenomas: a systematic review and meta-analysis. Am J Gastroenterol, 107, 1175–1185. doi: 10.1038/ajg.2012.180.

Omata, F., Deshpande, G. A., Ohde, S., Mine, T., & Fukui, T. (2013) The association between obesity and colorectal adenoma: systematic review and meta-analysis. Scand J Gastroenterol, 48, 136–146. doi: 10.3109/00365521.2012.737364.

Zauber, A. G., Winawer, S. J., O’Brien, M. J., Lansdorp-Vogelaar, I., van Ballegooijen, M., Hankey, B.F. et al. (2012) Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med, 366, 687–696. doi: 10.1056/NEJMoa1100370.

How to Cite

Mylytsya KN, Maslov OI. Abdominal obesity as the colorectal adenomas risk factor. Zaporozhye Medical Journal [Internet]. 2016Nov.10 [cited 2024Jul.20];18(5). Available from: http://zmj.zsmu.edu.ua/article/view/82625



Original research